Active substance

Acetaminophen + Diphenhydramine Hydrochloride

2 products from 2 companies contain this in Canada.

2 without prescriptiontabletpowder for solution

Available without a prescription

EXTRA STRENGTH TYLENOL NIGHTTIME500 mg + 25 mgWithout prescriptiontablet Kenvue Canada Inc. · Acetaminophen + Diphenhydramine Hydrochloride · N02BE51 NEOCITRAN EXTRA STRENGTH COLD & COUGH NIGHT650 mg + 25 mgWithout prescriptionpowder for solution Haleon Canada Ulc · Acetaminophen + Diphenhydramine Hydrochloride · N02BE51

Same substance is not the same product. Strength, form, release mechanism and other ingredients all differ. Whether one can replace another is a decision for a pharmacist.