Active substance

Diphenhydramine Hydrochloride + Acetaminophen

2 products from 2 companies contain this in Canada.

2 without prescriptiontabletpowder for solution

Available without a prescription

ACETAMINOPHEN WITH ANTIHISTAMINE NIGHTTIME25 mg + 500 mgWithout prescriptiontablet Laboratoires Trianon Inc. · Diphenhydramine Hydrochloride + Acetaminophen · N02BE51 NYQUIL HOT REMEDY25 mg + 650 mgWithout prescriptionpowder for solution Procter & Gamble Inc · Diphenhydramine Hydrochloride + Acetaminophen · N02BE01

Same substance is not the same product. Strength, form, release mechanism and other ingredients all differ. Whether one can replace another is a decision for a pharmacist.