CLOZARIL
As listed in the register: CLOZARIL
50 mg · tablet
- Prescription only
- Pain, sleep, mood, epilepsy and the brain
- Active substance
- Clozapine
- Made by
- Hls Therapeutics Inc
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (VERSACLOZ). It describes the substance, not this exact product.
The mechanism of action of clozapine is unknown.
However, it has been proposed that the therapeutic efficacy of clozapine in schizophrenia is mediated through antagonism of the dopamine type 2 (D 2 ) and the serotonin type 2A (5-HT 2A ) receptors.
Metabolism and Excretion VERSACLOZ is almost completely metabolized prior to excretion, and only trace amounts of unchanged drug are detected in the urine and feces.
Approximately 50% of the administered dose is excreted in the urine and 30% in the feces.
When VERSACLOZ was administered after a high fat meal there was no effect on the AUC ss or C min, ss, however C max was reduced about 20%, and there was a slight delay in T max of 0.5 hour from a median T max of 2.0 hours under fasted conditions to 2.5 hours under fed conditions.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-09-06
Safety of the active substance
From the US prescribing label for the same active substance (VERSACLOZ). It describes the substance, not this exact product.
Prior to initiating VERSACLOZ treatment, obtain baseline ANC(s).
- VERSACLOZ is contraindicated in patients with a history of hypersensitivity to clozapine (e.g., photosensitivity, vasculitis, erythema multiforme, or Stevens-Johnson Syndrome) or any other component of VERSACLOZ [see Adverse Reactions (6.2) ].
- Known hypersensitivity to clozapine or any other component of VERSACLOZ ( 4 ).
Most common adverse reactions (≥5%) were: CNS reactions (sedation, dizziness/vertigo, headache, and tremor); cardiovascular reactions (tachycardia, hypotension, and syncope); autonomic nervous system reactions (hypersalivation, sweating, dry mouth, and visual disturbances); gastrointestinal reactions (constipation and nausea); and fever ( 6.1 ).
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
Spain4 matching products
FranceNo exact match for this strength and form
Netherlands8 matching products
- Ayupine 50 mg 50 mg · orodispergeerbare tablet
- Clozapine 50 mg 50 mg · tablet
- Clozapine Accord 50 mg 50 mg · tablet
- Clozapine Aristo 50 mg 50 mg · tablet
- Clozapine Glenmark 50 mg tabletten 50 mg · tablet
- Clozapine Leyden Delta 50 mg 50 mg · tablet
- Clozapine Sandoz 50 50 mg · tablet
- Zaponex 50 mg 50 mg · orodispergeerbare tablet
SwitzerlandNo exact match for this strength and form
Details
| Made by | Hls Therapeutics Inc |
|---|---|
| Active substance | Clozapine |
| Used in | Pain, sleep, mood, epilepsy and the brain |
| Strength | 50 mg |
| Form | tablet |
| Classification | N05AH02 · Pain, sleep, mood, epilepsy and the brain |
| Route | oral |
| Dispensing (as stated by the register) | PRESCRIPTION |
| Status | Marketed |
| Marketed | Yes, according to the register |
| DIN | 02490668 |
| DPD drug code | 98072 |
Source: Drug Product Database · 2026-09-30 · not reviewed by a clinician
Contains information licensed under the Open Government Licence – Canada. Reuse terms: Open Government Licence – Canada.
Other strengths and forms
4 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.