EMEND
As listed in the register: EMEND
80 mg · capsule
- Prescription only
- Digestion, stomach, diabetes and nutrition
- Active substance
- Aprepitant
- Made by
- Merck Canada Inc
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (APREPITANT). It describes the substance, not this exact product.
Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK 1 ) receptors.
Aprepitant has little or no affinity for serotonin (5-HT 3 ), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).
In vitro studies using human liver microsomes indicate that aprepitant is metabolized primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19.
Aprepitant is eliminated primarily by metabolism; aprepitant is not renally excreted.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-06-11
Safety of the active substance
From the US prescribing label for the same active substance (APREPITANT). It describes the substance, not this exact product.
- Aprepitant is contraindicated in patients:. who are hypersensitive to any component of the product.
- Hypersensitivity reactions including anaphylactic reactions have been reported [see Adverse Reactions ( 6.2 )].. taking pimozide.
- Inhibition of CYP3A4 by aprepitant could result in elevated plasma concentrations of this drug which is a CYP3A4 substrate, potentially causing serious or life-threatening reactions, such as QT prolongation, a known adverse reaction of pimozide [see Warnings and Precautions ( 5.1 )]..
- Known hypersensitivity to any component of this drug.
Most common adverse reactions (≥3%) are ( 6.1 ): Prevention of Chemotherapy Induced Nausea and Vomiting (CINV).
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United States6 matching products
European UnionNo exact match for this strength and form
Spain4 matching products
Netherlands9 matching products
- Aprepitant Accord 80 mg harde capsules 80 mg · capsule, hard
- Aprepitant Aurobindo 80 mg harde capsules 80 mg · capsule, hard
- Aprepitant CF 80 mg 80 mg · capsule, hard
- Aprepitant Sandoz 80 mg harde capsules 80 mg · capsule, hard
- Aprepitant Teva 80 mg 80 mg · capsule, hard
- Aprepitant Xiromed 80 mg harde capsules 80 mg · capsule, hard
- Aprepitant Zentiva 80 mg harde capsules 80 mg · capsule, hard
- Atanto 80 mg harde capsules 80 mg · capsule, hard
SwitzerlandNo exact match for this strength and form
Details
| Made by | Merck Canada Inc |
|---|---|
| Active substance | Aprepitant |
| Used in | Digestion, stomach, diabetes and nutrition |
| Strength | 80 mg |
| Form | capsule |
| Classification | A04AD12 · Digestion, stomach, diabetes and nutrition |
| Route | oral |
| Dispensing (as stated by the register) | PRESCRIPTION |
| Status | Marketed |
| Marketed | Yes, according to the register |
| DIN | 02298791 |
| DPD drug code | 78410 |
Source: Drug Product Database · 2026-09-30 · not reviewed by a clinician
Contains information licensed under the Open Government Licence – Canada. Reuse terms: Open Government Licence – Canada.
Other strengths and forms
2 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- capsule2 products
- 80 mg
- 125 mg
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.