LEUKERAN
As listed in the register: LEUKERAN
2 mg · tablet
- Prescription only
- Cancer treatments and immune-system medicines
- Active substance
- Chlorambucil
- Made by
- Aspen Pharmacare Canada Inc.
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (LEUKERAN). It describes the substance, not this exact product.
Chlorambucil, an aromatic nitrogen mustard derivative, is an alkylating agent.
Chlorambucil interferes with DNA replication and induces cellular apoptosis via the accumulation of cytosolic p53 and subsequent activation of Bax, an apoptosis promoter.
Chlorambucil is extensively metabolized in the liver primarily to phenylacetic acid mustard, which has antineoplastic activity.
The absorption of chlorambucil is reduced when taken after food.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2025-01-08
Safety of the active substance
From the US prescribing label for the same active substance (LEUKERAN). It describes the substance, not this exact product.
WARNING LEUKERAN (chlorambucil) can severely suppress bone marrow function.
- Chlorambucil should not be used in patients whose disease has demonstrated a prior resistance to the agent.
- Patients who have demonstrated hypersensitivity to chlorambucil should not be given the drug.
- There may be cross-hypersensitivity (skin rash) between chlorambucil and other alkylating agents.
The most common side effect is bone marrow suppression, anemia, leukopenia, neutropenia, thrombocytopenia, or pancytopenia.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
Spain2 matching products
FranceNo exact match for this strength and form
SwitzerlandNo exact match for this strength and form
Details
| Made by | Aspen Pharmacare Canada Inc. |
|---|---|
| Active substance | Chlorambucil |
| Used in | Cancer treatments and immune-system medicines |
| Strength | 2 mg |
| Form | tablet |
| Classification | L01AA02 · Cancer treatments and immune-system medicines |
| Route | oral |
| Dispensing (as stated by the register) | PRESCRIPTION |
| Status | Marketed |
| Marketed | Yes, according to the register |
| DIN | 00004626 |
| DPD drug code | 1193 |
Source: Drug Product Database · 2026-09-30 · not reviewed by a clinician
Contains information licensed under the Open Government Licence – Canada. Reuse terms: Open Government Licence – Canada.