MARCAINE
As listed in the register: MARCAINE
250 mg · solution
- Prescription status not stated
- Pain, sleep, mood, epilepsy and the brain
- Active substance
- Bupivacaine Hydrochloride
- Made by
- Pfizer Canada Ulc
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (EXPAREL). It describes the substance, not this exact product.
Local anesthetics block the generation and the conduction of nerve impulses presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential.
In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers.
Amide-type local anesthetics, such as bupivacaine, are metabolized primarily in the liver via conjugation with glucuronic acid.
Only 6% of bupivacaine is excreted unchanged in the urine.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2025-12-12
Safety of the active substance
From the US prescribing label for the same active substance (EXPAREL). It describes the substance, not this exact product.
- EXPAREL is contraindicated in obstetrical paracervical block anesthesia [see Use in Specific Populations (8.1) ].
- While EXPAREL has not been tested with this technique, the use of bupivacaine HCl with this technique has resulted in fetal bradycardia and death.
Most common adverse reactions (incidence greater than or equal to 10%) were nausea, constipation, and vomiting.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United StatesNo exact match for this strength and form
European UnionNo exact match for this strength and form
SpainNo exact match for this strength and form
NetherlandsNo exact match for this strength and form
SwitzerlandNo exact match for this strength and form
Details
| Made by | Pfizer Canada Ulc |
|---|---|
| Active substance | Bupivacaine Hydrochloride |
| Used in | Pain, sleep, mood, epilepsy and the brain |
| Strength | 250 mg |
| Form | solution |
| Classification | N01BB01 · Pain, sleep, mood, epilepsy and the brain |
| Route | block/infiltration |
| Dispensing (as stated by the register) | ETHICAL |
| Status | Marketed |
| Marketed | Yes, according to the register |
| DIN | 02305909 |
| DPD drug code | 79145 |
Source: Drug Product Database · 2026-09-30 · not reviewed by a clinician
Contains information licensed under the Open Government Licence – Canada. Reuse terms: Open Government Licence – Canada.
Other strengths and forms
3 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- solution3 products
- 5 mg + 0.0091 mg
- 150 mg
- 250 mg
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.