METADOL
As listed in the register: METADOL
1 mg · tablet
- Prescription only
- Pain, sleep, mood, epilepsy and the brain
- Active substance
- Methadone Hydrochloride
- Made by
- Knight Therapeutics Inc.
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (Methadone Hydrochloride). It describes the substance, not this exact product.
Methadone hydrochloride is a mu-agonist; a synthetic opioid with multiple actions qualitatively similar to those of morphine, the most prominent of which involves the central nervous system and organs composed of smooth muscle.
The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction.
Methadone is primarily metabolized by N-demethylation to an inactive metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidene (EDDP).
Cytochrome P450 enzymes, primarily CYP3A4, CYP2B6, CYP2C19, CYP2C9 and CYP2D6, are responsible for conversion of methadone to EDDP and other inactive metabolites, which are excreted mainly in the urine.
Effect of food on the bioavailability of methadone has not been evaluated.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2025-12-31
Safety of the active substance
From the US prescribing label for the same active substance (Methadone Hydrochloride). It describes the substance, not this exact product.
Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression may occur with use of methadone hydrochloride tablets, especially during initiation or following a dosage increase.
- Methadone hydrochloride tablets are contraindicated in patients with: Significant respiratory depression [see WARNINGS AND PRECAUTIONS ( 5.2 ) ].
- Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment [see WARNINGS AND PRECAUTIONS ( 5.10 ) ].
- Known or suspected gastrointestinal obstruction, including paralytic ileus [see WARNINGS AND PRECAUTIONS ( 5.14 ) ].
- Hypersensitivity (e.g., anaphylaxis) to methadone [see ADVERSE REACTIONS ( 6 ) ].
The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, vomiting, and sweating.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United StatesNo exact match for this strength and form
SpainNo exact match for this strength and form
NetherlandsNo exact match for this strength and form
SwitzerlandNo exact match for this strength and form
Details
| Made by | Knight Therapeutics Inc. |
|---|---|
| Active substance | Methadone Hydrochloride |
| Used in | Pain, sleep, mood, epilepsy and the brain |
| Strength | 1 mg |
| Form | tablet |
| Classification | N07BC02 · Pain, sleep, mood, epilepsy and the brain |
| Route | oral |
| Dispensing (as stated by the register) | NARCOTICS (CDSA I) |
| Status | Marketed |
| Marketed | Yes, according to the register |
| DIN | 02247698 |
| DPD drug code | 71959 |
Source: Drug Product Database · 2026-09-30 · not reviewed by a clinician
Contains information licensed under the Open Government Licence – Canada. Reuse terms: Open Government Licence – Canada.
Other strengths and forms
6 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.