PMS-METHOTREXATE TABLETS
As listed in the register: PMS-METHOTREXATE TABLETS
10 mg · tablet
- Prescription only
- Cancer treatments and immune-system medicines
- Active substance
- Methotrexate
- Made by
- Pharmascience Inc
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (Methotrexate). It describes the substance, not this exact product.
Methotrexate inhibits dihydrofolic acid reductase.
Dihydrofolates must be reduced to tetrahydrofolates by this enzyme before they can be utilized as carriers of one-carbon groups in the synthesis of purine nucleotides and thymidylate.
Methotrexate is partially metabolized by intestinal flora after oral administration.
Effect of Food Food has been shown to delay absorption and reduce peak concentration.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-27
Safety of the active substance
From the US prescribing label for the same active substance (Methotrexate). It describes the substance, not this exact product.
WARNING: EMBRYO-FETAL TOXICITY, HYPERSENSITIVITY REACTIONS, SEVERE ADVERSE REACTIONS, AND RISK OF MEDICATION ERRORS Methotrexate tablets can cause embryo-fetal toxicity, including fetal death.
- Methotrexate tablets are contraindicated in: Pregnant women receiving methotrexate tablets for treatment of non-neoplastic diseases [see Warnings and Precautions ( 5.1 ), and Use in Specific Populations ( 8.1, 8.3 )].
- Patients with a history of a severe hypersensitivity reactions, including anaphylaxis, to methotrexate [see Warnings and Precautions ( 5.2 )].
- In pregnancy for non-neoplastic diseases ( 4 ) History of severe hypersensitivity to methotrexate ( 4 )
The most common adverse reactions of methotrexate that exceeded the rate of placebo in 12- to 18-week double-blind studies in patients (n=128) with rheumatoid arthritis are listed below.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
European UnionNo exact match for this strength and form
SpainNo exact match for this strength and form
Netherlands2 matching products
SwitzerlandNo exact match for this strength and form
Details
| Made by | Pharmascience Inc |
|---|---|
| Active substance | Methotrexate |
| Used in | Cancer treatments and immune-system medicines |
| Strength | 10 mg |
| Form | tablet |
| Classification | L01BA01 · Cancer treatments and immune-system medicines |
| Route | oral |
| Dispensing (as stated by the register) | PRESCRIPTION |
| Status | Marketed |
| Marketed | Yes, according to the register |
| DIN | 02561956 |
| DPD drug code | 106487 |
Source: Drug Product Database · 2026-09-30 · not reviewed by a clinician
Contains information licensed under the Open Government Licence – Canada. Reuse terms: Open Government Licence – Canada.
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.