PRO-SIMVASTATIN
As listed in the register: PRO-SIMVASTATIN
20 mg · tablet
- Prescription only
- Heart, blood pressure and circulation
- Active substance
- Simvastatin
- Made by
- Pro Doc Limitee
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (SIMVASTATIN). It describes the substance, not this exact product.
Simvastatin is a prodrug and is hydrolyzed to its active β-hydroxyacid form, simvastatin acid, after administration.
Simvastatin acid and its metabolites are inhibitors of HMG-CoA reductase, the rate-limiting enzyme that converts HMG-CoA to mevalonate, a precursor of cholesterol.
Simvastatin is metabolized by CYP3A4.
Following an oral dose of 14 C-labeled simvastatin, 13% of the dose was excreted in urine and 60% in feces.
PK, assessed as area under the concentrations of total inhibitors –time curve, was apparently linear with doses up to 120 mg Effect of Food: The plasma profile of total inhibitors concentration was not affected when simvastatin was administered with low fat meal.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-31
Safety of the active substance
From the US prescribing label for the same active substance (SIMVASTATIN). It describes the substance, not this exact product.
- Simvastatin is contraindicated in the following conditions:.
- Concomitant use of strong CYP3A4 inhibitors (select azole anti-fungals, macrolide antibiotics, anti-viral medications, and nefazodone) [see DRUG INTERACTIONS ( 7.1 )]..
- Concomitant use of cyclosporine, danazol or gemfibrozil [see DRUG INTERACTIONS ( 7.1 )]..
- Acute liver failure or decompensated cirrhosis [see WARNINGS AND PRECAUTIONS ( 5.3 )].
Most common adverse reactions (incidence ≥5%) are: upper respiratory infection, headache, abdominal pain, constipation, and nausea.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United States28 matching products
Spain32 matching products
- ALCOSIN 20 mg simvastatina · comprimido recubierto con película
- BELMALIP 20 mg · comprimido recubierto con película
- GLUTASEY 20 mg simvastatina · comprimido recubierto
- PANTOK 20 mg · comprimido recubierto con película
- SIMVASTATINA ALMUS 20 mg simvastatina · comprimido recubierto con película
- SIMVASTATINA ALTER 20 mg · comprimido recubierto con película
- SIMVASTATINA APOTEX 20 MG · comprimido recubierto con película
- SIMVASTATINA ARAFARMA GROUP 20 MG · comprimido recubierto con película
Netherlands9 matching products
- Simvastatine 20 mg 20 mg · filmomhulde tablet
- Simvastatine 20 mg Teva 20 mg · filmomhulde tablet
- Simvastatine Accord 20 mg filmomhulde tabletten 20 mg · filmomhulde tablet
- Simvastatine Aurobindo 20 mg 20 mg · filmomhulde tablet
- Simvastatine CF 20 mg 20 mg · filmomhulde tablet
- Simvastatine Sandoz 20 mg 20 mg · filmomhulde tablet
- Simvastatine Viatris 20 mg 20 mg · filmomhulde tablet
- Zocor 20 mg 20 mg · filmomhulde tablet
SwitzerlandNo exact match for this strength and form
Details
| Made by | Pro Doc Limitee |
|---|---|
| Active substance | Simvastatin |
| Used in | Heart, blood pressure and circulation |
| Strength | 20 mg |
| Form | tablet |
| Classification | C10AA01 · Heart, blood pressure and circulation |
| Route | oral |
| Dispensing (as stated by the register) | PRESCRIPTION |
| Status | Marketed |
| Marketed | Yes, according to the register |
| DIN | 02247222 |
| DPD drug code | 71464 |
Source: Drug Product Database · 2026-09-30 · not reviewed by a clinician
Contains information licensed under the Open Government Licence – Canada. Reuse terms: Open Government Licence – Canada.
Other strengths and forms
5 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.