SIMVASTATIN
As listed in the register: SIMVASTATIN
40 mg · tablet
- Prescription only
- Heart, blood pressure and circulation
- Active substance
- Simvastatin
- Made by
- Sivem Pharmaceuticals Ulc
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (SIMVASTATIN). It describes the substance, not this exact product.
Simvastatin is a prodrug and is hydrolyzed to its active β-hydroxyacid form, simvastatin acid, after administration.
Simvastatin acid and its metabolites are inhibitors of HMG-CoA reductase, the rate-limiting enzyme that converts HMG-CoA to mevalonate, a precursor of cholesterol.
Simvastatin is metabolized by CYP3A4.
Following an oral dose of 14 C-labeled simvastatin, 13% of the dose was excreted in urine and 60% in feces.
PK, assessed as area under the concentrations of total inhibitors –time curve, was apparently linear with doses up to 120 mg Effect of Food: The plasma profile of total inhibitors concentration was not affected when simvastatin was administered with low fat meal.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-31
Safety of the active substance
From the US prescribing label for the same active substance (SIMVASTATIN). It describes the substance, not this exact product.
- Simvastatin is contraindicated in the following conditions:.
- Concomitant use of strong CYP3A4 inhibitors (select azole anti-fungals, macrolide antibiotics, anti-viral medications, and nefazodone) [see DRUG INTERACTIONS ( 7.1 )]..
- Concomitant use of cyclosporine, danazol or gemfibrozil [see DRUG INTERACTIONS ( 7.1 )]..
- Acute liver failure or decompensated cirrhosis [see WARNINGS AND PRECAUTIONS ( 5.3 )].
Most common adverse reactions (incidence ≥5%) are: upper respiratory infection, headache, abdominal pain, constipation, and nausea.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United States25 matching products
Spain32 matching products
- ALCOSIN 40 mg simvastatina · comprimido recubierto con película
- BELMALIP 40 mg · comprimido recubierto con película
- COLEMIN FORTE 40 mg · comprimido recubierto con película
- GLUTASEY 40 mg simvastatina · comprimido recubierto
- PANTOK FORTE 40 mg · comprimido recubierto con película
- SIMVASTATINA ALMUS 40 mg simvastatina · comprimido recubierto con película
- SIMVASTATINA ALTER 40 mg · comprimido recubierto con película
- SIMVASTATINA APOTEX 40 MG · comprimido recubierto con película
Netherlands9 matching products
- Simvastatine 40 mg 40 mg · filmomhulde tablet
- Simvastatine 40 mg Teva 40 mg · filmomhulde tablet
- Simvastatine Accord 40 mg filmomhulde tabletten 40 mg · filmomhulde tablet
- Simvastatine Aurobindo 40 mg 40 mg · filmomhulde tablet
- Simvastatine CF 40 mg 40 mg · filmomhulde tablet
- Simvastatine Sandoz 40 mg 40 mg · filmomhulde tablet
- Simvastatine Viatris 40 mg 40 mg · filmomhulde tablet
- Zocor 40 mg 40 mg · filmomhulde tablet
SwitzerlandNo exact match for this strength and form
Details
| Made by | Sivem Pharmaceuticals Ulc |
|---|---|
| Active substance | Simvastatin |
| Used in | Heart, blood pressure and circulation |
| Strength | 40 mg |
| Form | tablet |
| Classification | C10AA01 · Heart, blood pressure and circulation |
| Route | oral |
| Dispensing (as stated by the register) | PRESCRIPTION |
| Status | Marketed |
| Marketed | Yes, according to the register |
| DIN | 02386321 |
| DPD drug code | 87190 |
Source: Drug Product Database · 2026-09-30 · not reviewed by a clinician
Contains information licensed under the Open Government Licence – Canada. Reuse terms: Open Government Licence – Canada.
Other strengths and forms
10 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- tablet10 products
5 mg2
5 mg · 2 companies
10 mg2
10 mg · 2 companies
20 mg2
20 mg · 2 companies
40 mg2
40 mg · 2 companies
- Sanis Health Inc
- Sivem Pharmaceuticals Ulc · this page
80 mg2
80 mg · 2 companies
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.