METOPROLOL KRKA RETARD
As listed in the register: METOPROLOL KRKA RETARD 95 MG COMPRIMIDOS DE LIBERACION PROLONGADA EFG
95 mg (100 mg de metotrolol tartrato · comprimido de liberación prolongada
- Prescription only
- Heart, blood pressure and circulation
- Active substance
- Metoprolol
- Made by
- Krka D.D. Novo Mesto
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (metoprolol). It describes the substance, not this Bulgarian product — its uses and doses can differ.
Metoprolol is a beta 1 -selective (cardioselective) adrenergic receptor blocking agent.
This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta 2 -adrenoreceptors, chiefly located in the bronchial and vascular musculature.
Metoprolol tartrate is primarily metabolized by CYP2D6.
In most subjects (extensive metabolizers), less than 5% of an oral dose and less than 10% of an intravenous dose are excreted as unchanged drug in the urine.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-07-27
Safety of the active substance
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (metoprolol). It describes the substance, not this Bulgarian product — its uses and doses can differ.
- Metoprolol tartrate tablets are contraindicated in severe bradycardia, second-or third-degree heart block, cardiogenic shock, systolic blood pressure <100, decompensated heart failure, sick sinus syndrome (unless a permanent pacemaker is in place), and in patients who are hypersensitive to any component of this product..
- Known hypersensitivity to product components.
- Severe bradycardia: Greater than first degree heart block, or sick sinus syndrome without a pacemaker.
- Cardiogenic shock or decompensated heart failure.
Most common adverse reactions: tiredness, dizziness, depression, shortness of breath, bradycardia, hypotension, diarrhea, pruritus, rash.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United StatesNo exact match for this strength and form
BulgariaNo exact match for this strength and form
CanadaNo exact match for this strength and form
NetherlandsNo exact match for this strength and form
SwitzerlandNo exact match for this strength and form
Details
| Made by | Krka D.D. Novo Mesto |
|---|---|
| Active substance | Metoprolol |
| Used in | Heart, blood pressure and circulation |
| Strength | 95 mg (100 mg de metotrolol tartrato |
| Form | comprimido de liberación prolongada |
| Classification | C07AB02 · Heart, blood pressure and circulation |
| Route | vía oral |
| Marketed | No — authorised but not currently marketed, according to the register |
| Generic | Yes — a generic medicine, according to the register |
| Name in the register | METOPROLOL KRKA RETARD 95 MG COMPRIMIDOS DE LIBERACION PROLONGADA EFG |
| Nº Registro | 81030 |
Source: CIMA — Centro de Información online de Medicamentos · 2026-09-30 · not reviewed by a clinician
Fuente: Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), CIMA. Reuse terms: Aviso legal AEMPS.
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.