NEXAVAR
As listed in the register: NEXAVAR 200 mg COMPRIMIDOS RECUBIERTOS CON PELICULA
200mg de sorafenib (como tosilato) · comprimido recubierto con película
- Prescription only
- Cancer treatments and immune-system medicines
- Active substance
- Sorafenib
- Made by
- Bayer Ag
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (Sorafenib Tosylate). It describes the substance, not this exact product.
Sorafenib is a kinase inhibitor that decreases tumor cell proliferation in vitro.
Sorafenib was shown to inhibit multiple intracellular (c-CRAF, BRAF and mutant BRAF) and cell surface kinases (KIT, FLT-3, RET, RET/PTC, VEGFR-1, VEGFR-2, VEGFR-3, and PDGFR-ß).
Sorafenib undergoes oxidative metabolism by hepatic CYP3A4, as well as glucuronidation by UGT1A9.
Following oral administration of a 100 mg dose of a solution formulation of sorafenib, 96% of the dose was recovered within 14 days, with 77% of the dose excreted in feces and 19% of the dose excreted in urine as glucuronidated metabolites.
Effects of Food With a moderate-fat meal (30% fat; 700 calories), bioavailability was similar to that in the fasted state.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-03-18
Safety of the active substance
From the US prescribing label for the same active substance (Sorafenib Tosylate). It describes the substance, not this exact product.
- Sorafenib tablets are contraindicated in patients with known severe hypersensitivity to sorafenib or any other component of sorafenib tablets..
- Sorafenib tablets in combination with carboplatin and paclitaxel are contraindicated in patients with squamous cell lung cancer [see Warnings and Precautions (5.8) ]..
The most common adverse reactions (≥ 20%) are diarrhea, fatigue, infection, alopecia, hand-foot skin reaction, rash, weight loss, decreased appetite, nausea, gastrointestinal and abdominal pains, hypertension, and hemorrhage.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United States8 matching products
European UnionNo exact match for this strength and form
Canada2 matching products
Netherlands11 matching products
- FENESA 200 mg filmomhulde tabletten 200 mg · filmomhulde tablet
- Nexavar 200 mg 200 mg · filmomhulde tablet
- Sorafeb 200 mg 200 mg · filmomhulde tablet
- Sorafenib Accord 200mg 200mg · filmomhulde tablet
- Sorafenib betapharm 200 mg 200 mg · filmomhulde tablet
- Sorafenib G.L. Pharma 200 mg 200 mg · filmomhulde tablet
- Sorafenib Sandoz 200 mg 200 mg · filmomhulde tablet
- Sorafenib STADA 200 mg 200 mg · filmomhulde tablet
SwitzerlandNo exact match for this strength and form
Details
| Made by | Bayer Ag |
|---|---|
| Active substance | Sorafenib |
| Used in | Cancer treatments and immune-system medicines |
| Strength | 200mg de sorafenib (como tosilato) |
| Form | comprimido recubierto con película |
| Classification | L01EX02 · Cancer treatments and immune-system medicines |
| Route | vía oral |
| Marketed | No — authorised but not currently marketed, according to the register |
| Name in the register | NEXAVAR 200 mg COMPRIMIDOS RECUBIERTOS CON PELICULA |
| Nº Registro | 06342001IP |
Source: CIMA — Centro de Información online de Medicamentos · 2026-09-30 · not reviewed by a clinician
Fuente: Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), CIMA. Reuse terms: Aviso legal AEMPS.
Other strengths and forms
2 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- comprimido recubierto con película2 products
200mg de sorafenib (como tosilato)2
200mg de sorafenib (como tosilato) · 2 companies
- Bayer Ag · this page
- Bayer Ag
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.