Pomalidomide Krka

How to take it

These directions are for this exact strength and form. Another one is different.

• Pomalidomide Krka must be given to you by a doctor with experience in treating multiple myeloma.
• Always take your medicines exactly as your doctor has told you. Check with your doctor, pharmacist or nurse if you are not sure.
• When to take Pomalidomide Krka with other medicines Pomalidomide Krka with bortezomib and dexamethasone
• See the leaflets that come with bortezomib and dexamethasone for further information on their use and effects.
• Pomalidomide Krka, bortezomib and dexamethasone are taken in ‘treatment cycles’. Each cycle lasts 21 days (3 weeks).
• Look at the chart below to see what to take on each day of the 3-week cycle:
• Each day, look down the chart and find the correct day to see which medicines to take.
• Some days, you take all 3 medicines, some days just 2 or 1 medicines, and some days none at all.
• POM: Pomalidomide Krka; BOR: Bortezomib; DEX: Dexamethasone Cycle 1 to 8 Cycle 9 and onwards Medicine name Medicine name Day POM BOR DEX Day POM BOR DEX 1 √ √ √ 1 √ √ √ 2 √ √ 2 √ √ 3 √ 3 √ 4 √ √ √ 4 √ 5 √ √ 5 √ 6 √ 6 √ 7 √ 7 √ 8 √ √ √ 8 √ √ √ 9 √ √ 9 √ √ 10 √ 10 √ 11 √ √ √ 11 √ 12 √ √ 12 √ 13 √ 13 √ 14 √ 14 √ 15 15 16 16 17 17 18 18 19 19 20 20 21 21
• After completing each 3-week cycle, start a new one.
• Pomalidomide Krka with dexamethasone only
• See the leaflet that comes with dexamethasone for further information on its use and effects.
• Pomalidomide Krka and dexamethasone are taken in ‘treatment cycles’. Each cycle lasts 28 days (4 weeks).
• Look at the chart below to see what to take on each day of the 4-week cycle:
• Each day, look down the chart and find the correct day to see which medicines to take.
• Some days, you take both medicines, some days just 1 medicine, and some days none at all.
• POM: Pomalidomide Krka; DEX: Dexamethasone Medicine name Day POM DEX 1 √ √ 2 √ 3 √ 4 √ 5 √ 6 √ 7 √ 8 √ √ 9 √ 10 √ 11 √ 12 √ 13 √ 14 √ 15 √ √ 16 √ 17 √ 18 √ 19 √ 20 √ 21 √ 22 √
• After completing each 4-week cycle, start a new one.
• How much Pomalidomide Krka to take with other medicines Pomalidomide Krka with bortezomib and dexamethasone
• The recommended starting dose of Pomalidomide Krka is 4 mg per day.
• The recommended starting dose of bortezomib will be worked out by your doctor and based on your height and weight (1.3 mg/m body surface area).
• The recommended starting dose of dexamethasone is 20 mg per day. However, if you are over 75, the recommended starting dose is 10 mg per day.
• Pomalidomide Krka with dexamethasone only
• The recommended dose of Pomalidomide Krka is 4 mg per day.
• The recommended starting dose of dexamethasone is 40 mg per day. However, if you are over 75, the recommended starting dose is 20 mg per day.
• Your doctor may need to reduce the dose of Pomalidomide Krka, bortezomib or dexamethasone or stop one or more of these medicines based on the results of your blood tests, your general condition, other medicines you may be taking (e.g. ciprofloxacin, enoxacin and fluvoxamine) and if you experience side effects (especially rash or swelling) from treatment.
• If you suffer from liver or kidney problems your doctor will check your condition very carefully whilst you are receiving this medicine.
• How to take Pomalidomide Krka
• Do not break, open or chew the capsules. If powder from a broken capsule makes contact with the skin, wash the skin immediately and thoroughly with soap and water.
• Healthcare professionals, caregivers and family members should wear disposable gloves when handling the blister or capsule. Gloves should then be removed carefully to prevent skin exposure, placed in a sealable plastic polyethylene bag and disposed of in accordance with local requirements. Hands should then be washed thoroughly with soap and water. Women who are pregnant or suspect they may be pregnant should not handle the blister or capsule.
• Swallow the capsules whole, preferably with water.
• You can take the capsules either with or without food.
• Take your capsules at about the same time each day.
• Taking this medicine Do not try to push the capsules from the blister.
• To remove the capsule from the blister:
• 1. Hold the blister at the edges and gently tear along the perforations to separate one blister cell from the rest.
• 2. Pull up the edge of the foil and peel the foil off completely.
• 3. Tip the capsule out onto your hand.
• 4. Swallow the capsule whole, preferably with water.
• Your doctor will advise you of how and when to take Pomalidomide Krka if you have kidney problems and are receiving dialysis treatment.
• Duration of the treatment with Pomalidomide Krka You should continue the cycles of treatment until your doctor tells you to stop.
• If you take more Pomalidomide Krka than you should If you take more Pomalidomide Krka than you should, talk to a doctor or go to a hospital straight away. Take the medicine pack with you.
• If you forget to take Pomalidomide Krka If you forget to take Pomalidomide Krka on a day when you should, take your next capsule as normal the next day. Do not increase the number of capsules you take to make up for not taking Pomalidomide Krka the previous day.
• If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

From the package leaflet in EMA’s product information, p. 58–61.

Warnings and precautions

From the package leaflet in EMA’s product information, p. 56–58.

Other medicines

From the package leaflet in EMA’s product information, p. 58.

Driving and using machines

• Some people feel tired, dizzy, faint, confused or less alert when taking Pomalidomide Krka. If this happens to you, do not drive or operate tools or machinery.
• Pomalidomide Krka contains sodium and isomalt Pomalidomide Krka contains less than 1 mmol sodium (23 mg) per capsule, that is to say essentially “sodium-free”.
• Pomalidomide Krka contains isomalt. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

From the package leaflet in EMA’s product information, p. 58.

Side effects

• Like all medicines, this medicine can cause side effects, although not everybody gets them.
• Serious side effects Stop taking Pomalidomide Krka and see a doctor straight away if you notice any of the following serious side effects – you may need urgent medical treatment:
• Fever, chills, sore throat, cough, mouth ulcers or any other signs of infection (due to less white blood cells, which fight infection).
• Bleeding or bruising without a cause, including nosebleeds and bleeding from the bowels or stomach (due to effects on blood cells called ‘platelets’).
• Rapid breathing, rapid pulse, fever and chills, passing very little to no urine, nausea and vomiting, confusion, unconsciousness (due to infection of blood called sepsis or septic shock).
• Severe, persistent or bloody diarrhoea (possibly with stomach pain or fever) caused by bacteria called Clostridium difficile.
• Chest pain, or leg pain and swelling, especially in your lower leg or calves (caused by blood clots).
• Shortness of breath (from serious chest infection, inflammation of the lung, heart failure or blood clot).
• Swelling of face, lips, tongue and throat, which may cause difficulty breathing (due to serious types of allergic reaction called angioedema and anaphylactic reaction).
• Certain types of skin cancer (squamous cell carcinoma and basal cell carcinoma), which can cause changes in the appearance of your skin or growths on your skin. If you notice any changes to your skin whilst taking Pomalidomide Krka, tell your doctor as soon as possible.
• Recurrence of hepatitis B infection, which can cause yellowing of the skin and eyes, dark brown-coloured urine, right-sided abdominal pain, fever and feeling nauseous or being sick.
• Tell your doctor straightaway if you notice any of these symptoms.
• Widespread rash, high body temperature, enlarged lymph nodes and other body organs involvement (Drug Reaction with Eosinophilia and Systemic Symptoms which is also known as DRESS or drug hypersensitivity syndrome, Toxic Epidermal Necrolysis or Stevens-Johnson Syndrome). Stop using pomalidomide if you develop these symptoms and contact your doctor or seek medical attention immediately. See also section 2.
• Stop taking Pomalidomide Krka and see a doctor straight away if you notice any of the serious side effects listed above – you may need urgent medical treatment.
• Other side effects Very common (may affect more than 1 in 10 people):
• Shortness of breath (dyspnoea).
• Infections of the lungs (pneumonia and bronchitis).
• Infections of the nose, sinuses and throat, caused by bacteria or viruses.
• Flu-like symptoms (influenza).
• Low red blood cells, which may cause anaemia leading to tiredness and weakness.
• Low blood levels of potassium (hypokalaemia), which may cause weakness, muscle cramps, muscle aches, palpitations, tingling or numbness, dyspnoea, mood changes.
• High blood levels of sugar.
• A fast and irregular heartbeat (atrial fibrillation).
• Loss of appetite.
• Constipation, diarrhoea or nausea.
• Being sick (vomiting).
• Abdominal pain.
• Lack of energy.
• Difficulty in falling asleep or staying asleep.
• Dizziness, tremor.
• Muscle spasm, muscle weakness.
• Bone pain, back pain.
• Numbness, tingling or burning sensation to the skin, pains in hands or feet (peripheral sensory neuropathy).
• Swelling of the body, including swelling of the arms or legs.
• Rashes.
• Urinary tract infection, which may cause a burning sensation when passing urine, or a need to pass urine more often.
• Common (may affect up to 1 in 10 people):
• Fall.
• Bleeding within the skull.
• Decreased ability to move or feel (sensation) in your hands, arms, feet and legs because of nerve damage (peripheral sensorimotor neuropathy).
• Numbness, itching, and a feeling of pins and needles on your skin (paraesthesia).
• A spinning feeling in your head, making it difficult to stand up and move normally.
• Swelling caused by fluid.
• Hives (urticaria).
• Itchy skin.
• Shingles.
• Heart attack (chest pain spreading to the arms, neck, jaw, feeling sweaty and breathless, feeling sick or vomiting).
• Chest pain, chest infection.
• Increased blood pressure.
• A fall in the number of red and white blood cells and platelets at the same time (pancytopenia), which will make you more prone to bleeding and bruising. You may feel tired and weak, and short of breath and you are also more likely to get infections.
• Decreased number of lymphocytes (one type of white blood cells) often caused by infection (lymphopenia).
• Low blood levels of magnesium (hypomagnesaemia), which may cause tiredness, generalised weakness, muscle cramps, irritability and may result in low blood levels of calcium (hypocalcaemia), which may cause numbness and, or tingling of hands, feet, or lips, muscle cramps, muscle weakness, light-headedness, confusion.
• Low blood level of phosphate (hypophosphataemia), which may cause muscle weakness and irritability or confusion.
• High blood level of calcium (hypercalcaemia), which may cause slowing reflexes and skeletal muscle weaknesses.
• High blood levels of potassium, which may cause abnormal heart rhythm.
• Low blood levels of sodium, which may cause tiredness and confusion, muscle twitching, fits (epileptic seizures) or coma.
• High blood levels of uric acid, which may cause a form of arthritis called gout.
• Low blood pressure, which may cause dizziness or fainting.
• Sore or dry mouth.
• Changes in the way things taste.
• Swollen abdomen.
• Feeling confused.
• Feeling down (depressed mood).
• Loss of consciousness, fainting.
• Clouding of your eye (cataract).
• Damage to the kidney.
• Inability to pass urine.
• Abnormal liver test.
• Pain in the pelvis.
• Weight loss.
• Uncommon (may affect up to 1 in 100 people):
• Stroke.
• Inflammation of the liver (hepatitis) which can cause itchy skin, yellowing of the skin and the whites of the eyes (jaundice), pale coloured stools, dark coloured urine and abdominal pain.
• The breakdown of cancer cells resulting in the release of toxic compounds into the bloodstream (tumour lysis syndrome). This can result in kidney problems.
• Underactive thyroid gland, which may cause symptoms such as tiredness, lethargy, muscle weakness, slow heart rate, weight gain.
• Not known (frequency cannot be estimated from the available data):
• Rejection of solid organ transplant (such as heart or liver).
• Reporting of side effects If you get any side effects, talk to your doctor or pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.

From the package leaflet in EMA’s product information, p. 61–64.

How to store it

• Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated on the packaging after EXP. The expiry date refers to the last day of that month.
• This medicine does not require any special temperature storage conditions. Store in the original package in order to protect from moisture.
• Do not throw away any medicines via wastewater or household waste. Any unused medicine should be returned to your pharmacist at the end of treatment. These measures will help protect the environment.

From the package leaflet in EMA’s product information, p. 64.

Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

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Details

Source: European Medicines Agency — medicine data · 2026-09-30 · not reviewed by a clinician

Source: European Medicines Agency (EMA). Product information as published by EMA. Reuse terms: EMA legal notice (reproduction authorised).

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Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

See every product with Pomalidomide