Talmanco (previously Tadalafil Generics)

How to take it

These directions are for this exact strength and form. Another one is different.

• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• Talmanco is supplied as a 20 mg tablet. Swallow the tablet(s) whole with a drink of water. The tablet(s) can be taken with or without food.
• Pulmonary arterial hypertension in adults The usual dose is two 20 mg tablets taken once a day. You should take both tablets at the same time, one after the other. If you have a mild or moderate liver or kidney problem, your doctor may advise you to take only one 20 mg tablet per day.
• Pulmonary arterial hypertension in children (age 2 years and above) weighing at least 40 kg The recommended dose is two 20 mg tablets taken once a day. Both tablets should be taken at the same time, one after the other. If you have a mild or moderate liver or kidney problem, your doctor may advise you to take only one 20 mg tablet per day.
• Pulmonary arterial hypertension in children (age 2 years and above) weighing less than 40 kg The recommended dose is one 20 mg tablet taken once a day. If you have a mild or moderate liver or kidney problem, your doctor may advise you to take 10 mg once per day.
• Other form(s) of this medicine may be more suitable for children; ask your doctor or pharmacist.
• If you take more Talmanco than you should If you or anyone else takes more tablets than they should, tell your doctor or go to a hospital immediately, taking the medicine or pack with you. You may experience any of the side effects described in section 4.
• If you forget to take Talmanco Take your dose as soon as you remember if it is within 8 hours of when you should have taken your dose. Do not take a double dose to make up for a forgotten dose.
• If you stop taking Talmanco Do not stop taking your tablets, unless advised otherwise by your doctor.
• If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

From the package leaflet in EMA’s product information, p. 29.

Warnings and precautions

From the package leaflet in EMA’s product information, p. 27–28.

Pregnancy and breastfeeding

From the package leaflet in EMA’s product information, p. 28.

Other medicines

From the package leaflet in EMA’s product information, p. 28.

Driving and using machines

• Dizziness has been reported. Check carefully how you react to this medicine before driving or using any machinery.
• Talmanco contains lactose and sodium If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
• This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium- free’.

From the package leaflet in EMA’s product information, p. 28–29.

Side effects

• Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.
• If you experience any of the following side effects stop using the medicine and seek medical help immediately:
• Common (may affect up to 1 in 10 people)
• allergic reactions including skin rashes.
• chest pain - do not use nitrates, but seek immediate medical assistance.
• Uncommon (may affect up to 1 in 100 people)
• priapism, a prolonged and possibly painful erection after taking this medicine. If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately.
• Rare (may affect up to 1 in 1,000 people)
• sudden loss of vision.
• Not known (frequency cannot be estimated from the available data)
• distorted, dimmed, blurred central vision or sudden decrease of vision.
• Other side effects have been reported:
• Very Common (may affect more than 1 in 10 people)
• headache.
• flushing, nasal and sinus congestion (blocked nose).
• nausea, indigestion (including abdominal pain or discomfort).
• muscle aches, back pain and pain in the extremity (including limb discomfort).
• Common (may affect up to 1 in 10 people)
• blurred vision.
• low blood pressure.
• nosebleed.
• vomiting.
• increased or abnormal uterine bleeding.
• swelling of the face.
• acid reflux.
• migraine.
• irregular heartbeat.
• fainting.
• Uncommon (may affect up to 1 in 100 people)
• seizures.
• passing memory loss.
• hives.
• excessive sweating.
• penile bleeding.
• presence of blood in semen and/or urine.
• high blood pressure.
• fast heart rate.
• sudden cardiac death.
• ringing in the ears.
• PDE5 inhibitors are also used for the treatment of erectile dysfunction in men. Some side effects have been rarely (may affect up to 1 in 1,000 people) reported:
• Partial, temporary or permanent decrease or loss of vision in one or both eyes and serious allergic reaction which causes swelling of the face or throat. Sudden decrease or loss of hearing has also been reported.
• Some side effects have been reported in men taking tadalafil for the treatment of erectile dysfunction.
• These events were not seen in clinical trials for pulmonary arterial hypertension and therefore frequency is not known (frequency cannot be estimated from the available data):
• swelling of the eyelids, eye pain, red eyes, heart attack and stroke.
• Some additional rare side effects have been reported in men taking tadalafil that were not seen in clinical trials. These include:
• distorted, dimmed, blurred central vision or sudden decrease of vision (frequency not known).
• Most but not all of those men reporting fast heart rate, irregular heartbeat, heart attack, stroke and sudden cardiac death had known heart problems before taking tadalafil. It is not possible to determine whether these events were related directly to tadalafil.
• Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects you can help provide more information on the safety of this medicine.

From the package leaflet in EMA’s product information, p. 29–31.

How to store it

• Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated on the carton and blister after “EXP”.
• The expiry date refers to the last day of that month.
• This medicine does not require any special storage conditions.
• Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

From the package leaflet in EMA’s product information, p. 31.

Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

Medicine passport: one printable page to show a pharmacist abroad

Details

Source: European Medicines Agency — medicine data · 2026-09-30 · not reviewed by a clinician

Source: European Medicines Agency (EMA). Product information as published by EMA. Reuse terms: EMA legal notice (reproduction authorised).

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Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

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