Refusal
As listed in the register: Refusal, tabletten 250 mg
250 mg · tablet
- Prescription only
- Pain, sleep, mood, epilepsy and the brain
- Active substance
- Disulfiram
- Made by
- ACE Pharmaceuticals B.V.
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (Disulfiram). It describes the substance, not this exact product.
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol.
Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage.
This reaction, which is proportional to the dosage of both disulfiram and alcohol, will persist as long as alcohol is being metabolized.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-05-27
Safety of the active substance
From the US prescribing label for the same active substance (Disulfiram). It describes the substance, not this exact product.
WARNING Disulfiram should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge.
- Patients who are receiving or have recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations, e.g., cough syrups, tonics and the like, should not be given disulfiram.
- Disulfiram is contraindicated in the presence of severe myocardial disease or coronary occlusion, psychoses, and hypersensitivity to disulfiram or to other thiuram derivatives used in pesticides and rubber vulcanization.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
SwitzerlandNo exact match for this strength and form
Details
| Made by | ACE Pharmaceuticals B.V. |
|---|---|
| Active substance | Disulfiram |
| Used in | Pain, sleep, mood, epilepsy and the brain |
| Strength | 250 mg |
| Form | tablet |
| Classification | N07BB01 · Pain, sleep, mood, epilepsy and the brain |
| Route | oraal gebruik |
| Dispensing (as stated by the register) | Uitsluitend recept |
| Name in the register | Refusal, tabletten 250 mg |
| RVG | 03182 |
Source: Geneesmiddeleninformatiebank · 2026-09-30 · not reviewed by a clinician
Bron: College ter Beoordeling van Geneesmiddelen (CBG). De Rijksoverheid is het niet automatisch eens met de inhoud van deze site. Reuse terms: CC0 1.0 (CBG website).
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.