Active substance

Acetaminophen, Aspirin (nsaid), and Caffeine

3 products from 2 companies contain this in United States.

3 without prescriptionKitTablet, Film Coated

Available without a prescription

Excedrin Extra Strength and Excedrin Tension HeadacheWithout prescriptionKit Haleon US Holdings LLC · Acetaminophen, Aspirin (nsaid), and Caffeine Excedrin Extra Strength Pain Reliever250 mg + 250 mg + 65 mgWithout prescriptionTablet, Film Coated Haleon US Holdings LLC · Acetaminophen, Aspirin (nsaid), and Caffeine Excedrin Extra Strength Pain Reliever250 mg + 250 mg + 65 mgWithout prescriptionTablet, Film Coated Navajo Manufacturing Company Inc. · Acetaminophen, Aspirin (nsaid), and Caffeine

Same substance is not the same product. Strength, form, release mechanism and other ingredients all differ. Whether one can replace another is a decision for a pharmacist.