Active substance

Acetaminophen, Diphenhydramine Hydrochloride, and Phenylephrine Hydrochloride

5 products from 4 companies contain this in United States.

5 without prescriptionTablet, Film CoatedSolutionGranule, for SolutionPowder, for Solution

Available without a prescription

Acetaminophen, Diphenhydramine Hydrochloride, and Phenylephrine Hydrochloride325 mg + 12.5 mg + 5 mgWithout prescriptionTablet, Film Coated HHH Pharmaceuticals · Acetaminophen, Diphenhydramine Hydrochloride, and Phenylephrine Hydrochloride Childrens Delsym Cough Plus Cold Night Time325 mg/10mL + 12.5 mg/10mL + 5 mg/10mLWithout prescriptionSolution Reckitt Benckiser LLC · Acetaminophen, Diphenhydramine Hydrochloride, and Phenylephrine Hydrochloride Mucinex Childrens Night Time Multi-Symptom Cold325 mg/10mL + 12.5 mg/10mL + 5 mg/10mLWithout prescriptionSolution Reckitt Benckiser LLC · Acetaminophen, Diphenhydramine Hydrochloride, and Phenylephrine Hydrochloride Sanatos Severe Cold Relief Nighttime25 mg + 10 mg + 650 mgWithout prescriptionGranule, for Solution Pharmadel LLC · Acetaminophen, Diphenhydramine Hydrochloride, and Phenylephrine Hydrochloride Up and Up Nighttime Flu and Severe Cold and Cough650 mg + 25 mg + 10 mgWithout prescriptionPowder, for Solution Target Corporation · Acetaminophen, Diphenhydramine Hydrochloride, and Phenylephrine Hydrochloride

Same substance is not the same product. Strength, form, release mechanism and other ingredients all differ. Whether one can replace another is a decision for a pharmacist.