Active substance

Acetaminophen, Phenylephrine Hydrochloride, Doxylamine Succinate, and Dextromethorphan Hydrobromide

5 products from 2 companies contain this in United States.

5 without prescriptionTablet, Coated

Available without a prescription

Nyquil Severe Plus Vapocool Cold and Flu325 mg + 5 mg + 6.25 mg + 10 mgWithout prescriptionTablet, Coated Lil' Drug Store Products, Inc. · Acetaminophen, Phenylephrine Hydrochloride, Doxylamine Succinate, and Dextromethorphan Hydrobromide Nyquil Severe Plus Vapocool Cold and Flu, Cvp Health325 mg + 5 mg + 6.25 mg + 10 mgWithout prescriptionTablet, Coated Lil' Drug Store Products, Inc. · Acetaminophen, Phenylephrine Hydrochloride, Doxylamine Succinate, and Dextromethorphan Hydrobromide Nyquil Severe Plus Vapocool Cold and Flu, Travel Basix325 mg + 5 mg + 6.25 mg + 10 mgWithout prescriptionTablet, Coated Lil' Drug Store Products, Inc. · Acetaminophen, Phenylephrine Hydrochloride, Doxylamine Succinate, and Dextromethorphan Hydrobromide Nyquil Severe Plus Vicks Vapocool Cold and Flu10 mg + 325 mg + 5 mg + 6.25 mgWithout prescriptionTablet, Coated The Procter & Gamble Manufacturing Company · Acetaminophen, Phenylephrine Hydrochloride, Doxylamine Succinate, and Dextromethorphan Hydrobromide Vicks Nyquil Vapocool Severe Cold and Flu Plus Congestion325 mg + 5 mg + 6.25 mg + 10 mgWithout prescriptionTablet, Coated The Procter & Gamble Manufacturing Company · Acetaminophen, Phenylephrine Hydrochloride, Doxylamine Succinate, and Dextromethorphan Hydrobromide

Same substance is not the same product. Strength, form, release mechanism and other ingredients all differ. Whether one can replace another is a decision for a pharmacist.