Active substance

Aspirin, Dextromethorphan Hydrobromide, Phenylephrine Bitartrate

2 products from 2 companies contain this in United States.

2 without prescriptionTabletKit

Available without a prescription

Alka Seltzer Plus Cold Day and Night Effervescent325 mg + 10 mg + 7.8 mgWithout prescriptionTablet Sincronia Logistica, S.A. de C.V. · Aspirin, Dextromethorphan Hydrobromide, Phenylephrine Bitartrate Alka-Seltzer Plus Severe Cold Powerfast Fizz Day and NightWithout prescriptionKit Bayer HealthCare LLC. · Aspirin, Dextromethorphan Hydrobromide, Phenylephrine Bitartrate

Same substance is not the same product. Strength, form, release mechanism and other ingredients all differ. Whether one can replace another is a decision for a pharmacist.