Active substance

Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, and Phenylephrine Hydrochloride

2 products from 2 companies contain this in United States.

2 without prescriptionLiquidTablet, Coated

Available without a prescription

Dometuss2 mg/5mL + 10 mg/5mL + 5 mg/5mLWithout prescriptionLiquid Domel Laboratories · Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, and Phenylephrine Hydrochloride Ed-a-Hist Dm4 mg + 10 mg + 10 mgWithout prescriptionTablet, Coated EDWARDS PHARMACEUTICALS, INC. · Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, and Phenylephrine Hydrochloride

Same substance is not the same product. Strength, form, release mechanism and other ingredients all differ. Whether one can replace another is a decision for a pharmacist.