Active substance

Diphenhydramine Hydrochloride and Phenylephrine Hydrochloride

4 products from 2 companies contain this in United States.

4 without prescriptionTablet, Film CoatedSolutionKit

Available without a prescription

Benadryl Allergy Plus Congestion25 mg + 10 mgWithout prescriptionTablet, Film Coated Kenvue Brands LLC · Diphenhydramine Hydrochloride and Phenylephrine Hydrochloride Childrens Benadryl Allergy Plus Congestion12.5 mg/5mL + 5 mg/5mLWithout prescriptionSolution Kenvue Brands LLC · Diphenhydramine Hydrochloride and Phenylephrine Hydrochloride Dimetapp Nighttime Cold and Congestion6.25 mg/5mL + 2.5 mg/5mLWithout prescriptionSolution Foundation Consumer Brands · Diphenhydramine Hydrochloride and Phenylephrine Hydrochloride Sudafed Pe Sinus CongestionWithout prescriptionKit Kenvue Brands LLC · Diphenhydramine Hydrochloride and Phenylephrine Hydrochloride

Same substance is not the same product. Strength, form, release mechanism and other ingredients all differ. Whether one can replace another is a decision for a pharmacist.