Active substance

Diphenhydramine, Zinc Acetate

2 products from 2 companies contain this in United States.

2 without prescriptionSprayCream

Available without a prescription

Extra Strength Wal-Dryl Itch Relief20 mg/mL + 1 mg/mLWithout prescriptionSpray WALGREEN CO · Diphenhydramine, Zinc Acetate Medi First Extra Strength Itch Relief.001 g/g + .2 g/gWithout prescriptionCream Unifirst First Aid Corporation · Diphenhydramine, Zinc Acetate

Same substance is not the same product. Strength, form, release mechanism and other ingredients all differ. Whether one can replace another is a decision for a pharmacist.