Medicine guide

Rifadin

Kit

Prescription only

Active substance: Rifampicin
Made by: Sanofi-Aventis U.S. LLC
Source: Official label

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2026-08-25

Used for

Warning

Inform your doctor immediately while taking this medicine:

All warnings ↓

Good to know

Prescription only
FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

Tuberculosis (TB) The usual dose is:

3.
How Rifadin Infusion is given Rifadin Infusion is given by a doctor or nurse.
This is because it needs to be given as a slow drip into a vein (infusion).
How much is given
If you are not sure why
you are being given Rifadin Infusion or have any questions about how much Rifadin Infusion is being given to you, speak to your doctor or nurse.
-
Adults:
A single daily dose of 600mg given over 2–3 hours - Children:
Up to 20mg per kilogram of body weight each day.
The maximum dose is 600mg each day.
Leprosy Your doctor may prescribe a monthly or daily dose - Patients weighing less than 50kg:
A single daily dose of 450mg - Patients weighing more than 50kg:
A single daily dose of 600mg Brucellosis, Legionnaires Disease or other serious bacterial infections The amount
you are given will depend on how severe your infection is -
Adults:
600mg–1200mg each day.
The dose is given in 2–4 divided doses.
Elderly patients Your doctor may need to monitor you more closely.
People with Liver problems You should not be given any more than 8mg per kilogram of body weight each day.
If you are given more Rifadin Infusion than you should Your doctor will carefully calculate how much Rifadin Infusion you should get.
Therefore, it is unlikely your doctor or nurse will give you too much of this medicine.
But,
if you think that
you have been given too much or too little Rifadin Infusion, tell your doctor or nurse.
You may feel sick (nausea), be sick (vomiting), have stomach pain, itching or a headache.
You may also feel tired, sleepy, dizzy or light-headed.
Other signs of having too much includes swelling of the face, eyes or eyelids, slurring of speech, difficulty breathing, fast heartbeat, uneven heartbeats, fits and heart attack.
If you miss a dose of Rifadin Infusion Your doctor or nurse will have instructions on when to give you this medicine.
It is unlikely that you will not be given the medicine as it has been prescribed.
However, if you think you may have missed a dose, then talk to your doctor or nurse.
Tests Having Rifadin Infusion may affect the results of some blood tests.
In particular, tests for folate, vitamin B 12 and liver function.
If you are going to have a blood test, it is important to tell your doctor that
you are having Rifadin Infusion.

From the official label · 2026-08-25 · DailyMed

How it works

From the US prescribing label for the same active substance (rifampin). It describes the substance, not this exact product.

Oral Administration Rifampin is readily absorbed from the gastrointestinal tract.
Peak serum concentrations in healthy adults and pediatric populations vary widely from individual to individual.

Half-life0.66 h

Mostly cleared after≈ 3.3 hfive half-lives — our arithmetic

How it leaves the body

After absorption, rifampin is rapidly eliminated in the bile, and an enterohepatic circulation ensues.

With food

Absorption of rifampin is reduced by about 30% when the drug is ingested with food.

Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-03-12

Other warnings

Inform your doctor immediately while taking this medicine:
▲ If your symptoms of tuberculosis return or get worse (see section 4).
Talk to your doctor, nurse or pharmacist before having Rifadin Infusion if:
▲
You have liver problems ▲
You have any kidney problems and
if you are having more than 600mg rifampicin per day ▲
You have diabetes.
Your diabetes may become more difficult to control while taking this medicine. ▲ You feel numb or weak in your arms and legs (peripheral neuropathy) ▲
You are under weight or malnourished ▲
You have a rare blood problem called 'porphyria' ▲
You have a problem with bleeding or a tendency to bruise easily ▲
You have a history of lung inflammation (interstitial lung disease/pneumonitis) ▲ Your symptoms of tuberculosis return or get worse (Please see section 4 Possible side effects) ▲ You develop a rash or experience any symptoms of thrombotic microangiopathy during your treatment (see section 4 Possible side effects) ▲ You wear contact lenses.
Having Rifadin Infusion may permanently stain soft contact lenses. ▲ The person having this medicine is a child ▲
You are aged 65 years or older
If you are not sure if any of the above apply to you, talk to your doctor, nurse or pharmacist before having Rifadin Infusion.
Lung inflammation Inform your doctor immediately while having this medicine
if you develop new or sudden worsening of shortness of breath, possibly with a dry cough or fever not responding to antibiotic treatment.
These could be symptoms of lung inflammation (interstitial lung disease/pneumonitis) and can lead to serious breathing problems due to collection of fluid in the lungs and interfere with normal breathing which can lead to life threatening conditions.
Liver problems You should not have rifampicin, a component of Rifadin Infusion,
if you have previously taken any rifampicin containing medicinal product and had liver problems.
If you are unsure talk to your doctor.
Inflammation of the liver has been reported in patients taking rifampicin with symptoms developing within a few days to a few months following the start of treatment.
Stop using rifampicin and contact a doctor
if you have symptoms of liver problems (see section 4 Possible side effects).
Serious skin reactions Serious skin reactions including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP) have been reported with the use of Rifadin Infusion.
SJS/TEN can appear initially as reddish target spots or circular patches often with central blisters on the trunk.
Also, ulcers of mouth, throat, nose, genitals and eyes (red and swollen eyes) can occur.
These serious skin rashes are often preceded by fever and/or flu-like symptoms.
The rashes may progress to widespread peeling of the skin and life-threatening complications or be fatal.
DRESS appears initially as flu-like symptoms and a rash on the face then an extended rash with a high body temperature, increased levels of liver enzymes seen in blood tests and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes.
AGEP appears at the initiation of treatment as a red, scaly widespread rash with bumps under the skin and blisters accompanied by fever.
The most common location:
mainly localized on the skin folds, trunk, and upper extremities.
The highest risk for occurrence of serious skin reactions is within 2 days to 2 months after treatment initiation depending on the condition.
If you develop a serious rash or another of these skin symptoms, stop taking Rifadin Infusion and contact your doctor or seek medical attention immediately.
Blood Tests Your doctor will need to check your blood before you are given this medicine.
This will help your doctor know if any changes happen to your blood after having this medicine.
You may also need to have regular blood tests to check how your liver is working.
Other medicines and Rifadin Infusion Tell your doctor, nurse or pharmacist
if you are taking, have recently taken or might take any other medicines.
This includes medicines you buy without a prescription, including herbal medicines.
This is because Rifadin Infusion can affect the way some other medicines work.
Also, some medicines can affect the way Rifadin Infusion work.
if you are pregnant and planning or required to undergo pregnancy termination using mifepristone.
In particular, do not have this medicine, and tell your doctor,
if you are taking:
X Saquinavir or ritonavir used for HIV infection X Lurasidone used for schizophrenia and bipolar disorders The following medicines can make Rifadin Infusion work less well:
Antacids used for indigestion.
Have Rifadin Infusion at least 1 hour before taking antacids.
Other medicines used for TB such as P-aminosalicyclic acid (PAS).
PAS and Rifadin Infusion should be taken at least 8 hours apart.
Tell your doctor
if you are having any of the following medicines:
Heart and blood medicines Medicines for high blood pressure Medicines for heart problems or to control your heartbeat Medicines used to thin the blood such as warfarin and clopidogrel Medicines used to lower cholesterol Water tablets (diuretics) such as eplerenone Mental health, epilepsy and motor neurone medicines Medicines for thought disorders known as 'antipsychotics' such as haloperidol Medicines to calm or reduce anxiety (hypnotics, anxiolytics) Medicines to help you sleep (barbiturates) Medicines used for epilepsy such as phenytoin Some medicines used for depression such as amitriptyline and nortriptyline Riluzole – used for motor neurone disease Medicines for infections and the immune system Some medicines used for viral infections such as cabotegravir, fostemsavir, lenacapavir, indinavir, efavirenz, amprenavir, nelfinavir, atazanavir, lopinavir, neviparine, daclatasvir, simeprevir, sofosbuvir and telaprevir Medication for the treatment of fungal infections such as caspofungin, fluconazole, itraconazole, ketoconazole Medicines used for bacterial infections (antibiotics) Dapsone (an antibiotic) with rifampicin may cause haematological toxicity including a decrease in bone marrow and blood cells, and methaemoglobinaemia (decrease in oxygen in your blood caused by changes in red blood cells) Medicines used for lowering your immune system such as ciclosporin, sirolimus and tacrolimus Praziquantel – used for tapeworm infections Atovaquone – used for pneumonia Hormone and cancer medicines Some hormone medicines (oestrogen, systemic hormones, progestogens) used for contraception or some types of cancer such as ethinyloestradiol, levonorgestrel or dydrogesterone Some hormone medicines (anti-oestrogens) used for breast cancer or endometriosis such as tamoxifen, toremifene and gestrinone Some medicines used for cancer (cytotoxics) such as imatinib Levothyroxine (thyroid hormone) used for thyroid problems Irinotecan – used for cancer Pain, inflammation and gout medicines Non-steroidal anti-inflammatory drugs (NSAIDS) such as etoricoxib, aspirin and indomethacin Medicines used for pain such as codeine, morphine, fentanyl or pethidine Paracetamol and rifampicin can increase the risk of liver damage Corticosteroids used for inflammation such as hydrocortisone, betamethasone and prednisolone Methadone – used for heroin withdrawal Other medicines Medicines used for diabetes Medicines used to relax muscles before surgery (anaesthetics) such as halothane Some medicines used for feeling sick or being sick such as ondansetron and aprepitant Other antibiotic medicines such as cefazolin Quinine – used for malaria Theophylline – used for wheezing or difficulty in breathing Pregnancy and breast-feeding Talk to your doctor before having this medicine
if you are pregnant, plan to get pregnant or think
you are pregnant.
Rifadin Infusion may make the contraceptive "pill" work less well.
This means you should change to a different type of contraception.
Instead, you must use a reliable barrier method of contraception such as condoms or the "coil" while having Rifadin Infusion.
If you have any questions or are unsure about this talk to your doctor, nurse or pharmacist.
You should not breast-feed if you are having Rifadin Infusion.
This is because small amounts may pass into the mothers' milk.
If you are breast-feeding or planning to breast feed, talk to your doctor, nurse or pharmacist before taking any medicine.
Driving and using machines You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive while having this medicine.
If this happens, do not drive or use any tools or machines.
Rifadin Infusion contains sodium This medicine contains less than 1mmol sodium (23mg) per daily dose, that is to say essentially 'sodium-free'.

Quoted from the official label, section “Warnings”.

If you take too much

In an emergency, call your local emergency number or a poison control centre.

Overdose Human Experience Signs and Symptoms Nausea, vomiting, abdominal pain, pruritus, headache and increasing lethargy will probably occur within a short time after acute ingestion; unconsciousness may occur when there is severe hepatic disease.
Transient increases in liver enzymes and/or bilirubin may occur.
Brownish-red or orange colouration of the skin, urine, sweat, saliva, tears and faeces will occur, and its intensity is proportional to the amount ingested.
Facial or periorbital oedema has also been reported in paediatric patients.
Hypotension, sinus tachycardia, ventricular arrhythmias, seizures and cardiac arrest were reported in some fatal cases.
The minimum acute lethal or toxic dose is not well established.
However, nonfatal acute overdoses in
adults have been reported with doses ranging from 9–12g rifampicin.
Fatal acute overdoses in adults have been reported with doses ranging from 14 – 60g.
Alcohol or a history of alcohol abuse was involved in some of the fatal and nonfatal reports.
Nonfatal overdoses in paediatric patients ages 1–4 years old of 100mg/kg for one to two doses have been reported.
Management Intensive supportive measures should be instituted, and individual symptoms treated as they arise.
Since nausea and vomiting are likely to be present, gastric lavage is probably preferable to induction of emesis.
Following evacuation of the gastric contents, the instillation of activated charcoal slurry into the stomach may help absorb any remaining drug from the gastrointestinal tract.
Antiemetic medication may be required to control severe nausea and vomiting.
Active diuresis (with measured intake and output) will help promote excretion of the drug.
Haemodialysis may be of value in some patients.
Incompatibilities Compatibilities:
up to 6 hours with Saline Solution and up to 8 hours with Glucose 5%.
Incompatibilities:
Perfudex, Sodium Bicarbonate 5%, Sodium Lactate 0.167M, Ringer Acetate with Glucose.
Shelf life Unopened vial of lyophilisate:
36 months Unopened ampoule of solvent:
60 months Shelf life after dilution or reconstitution:
Up to 30 hours with Water for injections (10ml WFI) Up to 8 hours with Water for injections (10ml WFI) and then diluted in glucose 5% solution for infusion Up to 6 hours with Water for injections (10ml WFI) and then diluted in sodium chloride 0.9% solution for infusion Special precautions for storage Store below 25°C.

Quoted from the official label, section “Overdosage”.

Side effects

4.
Possible side effects Like all medicines, Rifadin Infusion can cause side effects, although not everybody gets them.
Tell a nurse or doctor straight away
if you notice any of the following serious side effects:
You have an allergic reaction .
The signs may include:
a rash, swallowing or breathing problems, wheezing, swelling of your lips, face, throat or tongue.
Nausea (feeling sick) or vomiting (being sick) fever, feeling tired, loss of appetite (anorexia), dark-coloured urine, light-coloured faeces, yellowing of the skin or whites of the eyes, itching, rash or upper stomach pain.
These symptoms may be signs of liver injury.
Serious skin rashes including Stevens-Johnson syndrome, toxic epidermal necrolysis.
These can appear as reddish target-like macules or circular patches often with central blisters on the trunk, skin peeling, ulcers of mouth, throat, nose, genitals and eyes and can be preceded by fever and flu-like symptoms.
See also section 2 .
Widespread rash, high body temperature, liver enzyme elevations, blood abnormalities (eosinophilia), enlarged lymph nodes and other body organs involvement (Drug Reaction with Eosinophilia and Systemic Symptoms which is also known as DRESS or drug hypersensitivity syndrome).
See also section 2 .
A red, scaly widespread rash with bumps under the skin and blisters accompanied by fever at the initiation of treatment (acute generalized exanthematous pustulosis).
See also section 2 .
You bruise more easily than usual.
Or you may have a painful rash of dark red spots under the skin which do not go away when you press on them (purpura).
This could be because of a serious blood problem.
You have high blood levels of uric acid
You have severe bleeding (haemorrhage) Paradoxical drug reaction - Symptoms of tuberculosis can return, or new symptoms can occur after initial improvement during treatment.
Paradoxical reactions have been reported as early as 2 weeks and as late as 18 months after beginning anti-tuberculosis treatment.
Paradoxical reactions are typically associated with fever, swollen lymph nodes (lymphadenitis), breathlessness, and cough.
Patients with paradoxical drug reaction can also experience headaches, loss of appetite, and weight loss.
You have chills, tiredness, unusually pale skin colour, shortness of breath, fast heartbeat or dark-coloured urine.
This could be signs of a serious type of anaemia.
You have blood in your urine or an increase or decrease in amount of urine you produce.
You may also get swelling, especially of the legs, ankles or feet.
This may be caused by serious kidney problems.
You have a sudden severe headache.
This could be a sign of bleeding in the brain.
New or sudden worsening of shortness of breath and wheezing, possibly with a cough or fever.
These could be symptoms of inflammation of the lungs (interstitial lung disease/pneumonitis).
You get confused, sleepy, cold clammy skin, shallow or difficult breathing, a racing heartbeat or your skin is paler than normal.
These could be signs of shock.
You get more infections more easily than normal.
Signs include fever, sore throat or mouth ulcers.
This could be because you have a low number of white blood cells.
You have bleeding from your nose, ear, gums, throat, skin or stomach.
Signs may include a feeling of tenderness and swelling in your stomach, purple spots on your skin and black or tar-like stools.
Mental problems with unusual thoughts and strange visions (hallucinations) Severe watery diarrhoea that will not stop and
you are feeling weak and have a fever.
This may be something called 'Pseudomembranous colitis'.
Flu-like symptoms including chills, fever, headache, dizziness and bone pains Inflammation of the liver – yellowing of the skin and white part of eyes, increase in the blood level of liver enzymes.
Blood clots in small blood vessels (thrombotic microangiopathy) – Symptoms may include increased bruising, bleeding, fever, extreme weakness, headache, dizziness or light-headedness.
Your doctor may find changes in your blood and the function of your kidneys.
Tell your doctor as soon as possible
if you have any of the following side effects:
Water retention (oedema) which may cause swollen face, stomach, arms or legs Muscle weakness or pain or loss of muscle reflexes Dizziness, feel lightheaded and faint especially when you stand or sit up quickly (due to low blood pressure) Swollen fingers, toes or ankles Being unable to concentrate, feeling nervous, irritable or depressed Feeling very tired and weak or difficulty sleeping (insomnia) Short-term memory loss, anxiety, being less alert or responsive Wasting of muscles or other body tissues Weight loss, night sweats and fever.
These could be signs of a blood condition called eosinophilia.
Feeling sick (nausea) or being sick (vomiting) Tell your doctor, nurse or pharmacist if any of the following side effects get serious or lasts longer than a few days:
Skin flushing or itching Irregular periods Loss of appetite (anorexia) Headache Diarrhoea or stomach discomfort Pain, redness or swelling at the site of injection Other side effects you should discuss with your doctor
if you are concerned about them You notice a discolouration (yellow, brown, orange or red colour) in your teeth, urine, sweat, phlegm (sputum), saliva or tears.
This is quite common, and you need not worry.
However, the colour may permanently stain soft contact lenses.
The colour in tears may last for some time after
you have stopped having Rifadin Infusion.
Blood tests A blood test may show changes in the way the liver is working.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse.
This includes any possible side effects not listed in this leaflet.
You can also report side effects directly via the Yellow Card Scheme at:
www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects you can help provide more information on the safety of this medicine.

Quoted from the official label, section “Adverse Reactions”.

What it looks like and how it is packed

5.
How to store Rifadin Infusion This medicine will be kept by your doctor or nurse in a safe place out of the sight and reach of children.
Do not use Rifadin Infusion after the expiry date which is stated on the carton and label after EXP.
The expiry date refers to the last day of that month.
Store below 25°C You will not be asked to store your medicine.
It will be brought to you ready to be given straight away.
Do not throw away any medicines via wastewater.
These measures will help protect the environment

Quoted from the official label, section “How Supplied”.

How to store it

Store below 25°C You will not be asked to store your medicine. It will be brought to you ready to be given straight away. Do not throw away any medicines via wastewater. These measures will help protect the environment

Quoted from the official label, section “Storage and Handling”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

The stored label for this product has no list of inactive ingredients. The list on the pack is the one to check.

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

Medicine passport: one printable page to show a pharmacist abroad

CanadaNo exact match for this strength and form

Every strength and form (2)

Details

Made by	Sanofi-Aventis U.S. LLC
Active substance	Rifampicin
Form	Kit
Packs	1 KIT in 1 CARTON * 10 mL in 1 VIAL * 10 mL in 1 AMPULE
NDC	0068-0660

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

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