Medicine guide

Shiseido Benefiance Wrinkle Smoothing Day

1.295 g/50mL + 2.331 g/50mL + 2.331 g/50mL + 2.59 g/50mL · Cream

  • Available without prescription
Made by
Shiseido Americas Corporation

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2026-04-01

What it is

Active Ingredients Purpose Avobenzone 2.5% Sunscreen Homosalate 4.5% Sunscreen Octisalate 4.5% Sunscreen Octocrylene 5.0% Sunscreen

Used for
  • Helps prevent sunburn
Do not take it if

On damaged or broken skin

All warnings ↓
Good to know
  • Sold without a prescription
  • FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
128other products contain Avobenzone, Homosalate, Octisalate, and Octocrylene — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

  • helps prevent sunburn

From the official label · 2026-04-01 · DailyMed

Do not take it if

on damaged or broken skin

Quoted from the official label, section “OTC — Do Not Use”.

How to take it

These directions are for this exact strength and form. Another one is different.

  • apply liberally 15 minutes before sun exposure use a water resistant sunscreen if swimming or sweating reapply at least every 2 hours Sun Protection Measures. Spending time in the sun increase your risk of skin cancer and early skin aging. To decrease this risk, regularly use a sunscreen with a Broad Spectrum SPF value of 15 or higher and other sun protection measures including:
  • limit time in the sun, especially from 10 a.m. - 2 p.m.
  • wear long-sleeved shirts, pants, hats, and sunglasses
  • children under 6 months:
  • ask a doctor

Quoted from the official label, section “Dosage & Administration”.

Stop and get help if

rash occurs

Quoted from the official label, section “OTC — Stop Use”.

Other warnings

  • For external use only
  • keep out of eyes. Rinse with water to remove

Quoted from the official label, section “Warnings”.

Keep away from children

If product is swallowed, get medical help or contact Poison Control Center right away

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

How to store it

protect this product in this container from excessive heat and direct sun.

Quoted from the official label, section “Storage and Handling”.

What kind of medicine it is

Active Ingredients Purpose Avobenzone 2.5% Sunscreen Homosalate 4.5% Sunscreen Octisalate 4.5% Sunscreen Octocrylene 5.0% Sunscreen

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

Water・Glycerin・Dipropylene Glycol・Dimethicone・Alcohol Denat.・C12-15 Alkyl Benzoate・Behenyl Alcohol・Butylene Glycol・Silica・Diphenylsiloxy Phenyl Trimethicone・Isododecane・Sorbitol・Stearyl Alcohol・Phytosteryl Macadamiate・Erythritol・Tocopheryl Acetate・PEG/PPG-14/7 Dimethyl Ether・PEG/PPG-17/4 Dimethyl Ether・Xanthan Gum・Caffeine・Sapindus Mukorossi Peel Extract・Angelica Keiskei Leaf/Stem Extract・Camellia Sinensis Leaf Extract・Citrus Junos Seed Extract・Ziziphus Jujuba Fruit Extract・Eucheuma Serra/Grateloupia Sparsa/Saccharina Angustata/Ulva Linza/Undaria Pinnatifida Extract・Potentilla Erecta Root Extract・Polyquaternium-51・Saccharina Angustata/Undaria Pinnatifida Extract・Chlorella Vulgaris Extract・Beheneth-20・Batyl Alcohol・Alcohol・Succinoglycan・Trisodium EDTA・Sodium Citrate・Sodium Metaphosphate・BHT・Citric Acid・Sodium Metabisulfite・PPG-3 Dipivalate・Tocopherol・Phenoxyethanol・Fragrance・Iron Oxides・

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

Call toll free 1-800-906-7503

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

  • Sugar alcoholsWater・Glycerin・Dipropylene Glycol・Dimethicone・Alcohol Denat.・C12-15 Alkyl Benzoate・Behenyl Alcohol・Butylene Glycol・Silica・Diphenylsiloxy Phenyl Trimethicone・Isododecane・Sorbitol・Stearyl Alcohol・Phytosteryl Macadamiate・Erythritol・Tocopheryl Acetate・PEG/PPG-14/7 Dimethyl Ether・PEG/PPG-17/4 Dimethyl Ether・Xanthan Gum・Caffeine・Sapindus Mukorossi Peel Extract・Angelica Keiskei Leaf/Stem Extract・Camellia Sinensis Leaf Extract・Citrus Junos Seed Extract・Ziziphus Jujuba Fruit Extract・Eucheuma Serra/Grateloupia Sparsa/Saccharina Angustata/Ulva Linza/Undaria Pinnatifida Extract・Potentilla Erecta Root Extract・Polyquaternium-51・Saccharina Angustata/Undaria Pinnatifida Extract・Chlorella Vulgaris Extract・Beheneth-20・Batyl Alcohol・Alcohol・Succinoglycan・Trisodium EDTA・Sodium Citrate・Sodium Metaphosphate・BHT・Citric Acid・Sodium Metabisulfite・PPG-3 Dipivalate・Tocopherol・Phenoxyethanol・Fragrance・Iron Oxides・Sorbitol and similar can upset the stomach and matter with fructose intolerance.
  • Alcohol (ethanol)Water・Glycerin・Dipropylene Glycol・Dimethicone・Alcohol Denat.・C12-15 Alkyl Benzoate・Behenyl Alcohol・Butylene Glycol・Silica・Diphenylsiloxy Phenyl Trimethicone・Isododecane・Sorbitol・Stearyl Alcohol・Phytosteryl Macadamiate・Erythritol・Tocopheryl Acetate・PEG/PPG-14/7 Dimethyl Ether・PEG/PPG-17/4 Dimethyl Ether・Xanthan Gum・Caffeine・Sapindus Mukorossi Peel Extract・Angelica Keiskei Leaf/Stem Extract・Camellia Sinensis Leaf Extract・Citrus Junos Seed Extract・Ziziphus Jujuba Fruit Extract・Eucheuma Serra/Grateloupia Sparsa/Saccharina Angustata/Ulva Linza/Undaria Pinnatifida Extract・Potentilla Erecta Root Extract・Polyquaternium-51・Saccharina Angustata/Undaria Pinnatifida Extract・Chlorella Vulgaris Extract・Beheneth-20・Batyl Alcohol・Alcohol・Succinoglycan・Trisodium EDTA・Sodium Citrate・Sodium Metaphosphate・BHT・Citric Acid・Sodium Metabisulfite・PPG-3 Dipivalate・Tocopherol・Phenoxyethanol・Fragrance・Iron Oxides・Matters for children, in pregnancy, in recovery and with some medicines.
  • SulfitesWater・Glycerin・Dipropylene Glycol・Dimethicone・Alcohol Denat.・C12-15 Alkyl Benzoate・Behenyl Alcohol・Butylene Glycol・Silica・Diphenylsiloxy Phenyl Trimethicone・Isododecane・Sorbitol・Stearyl Alcohol・Phytosteryl Macadamiate・Erythritol・Tocopheryl Acetate・PEG/PPG-14/7 Dimethyl Ether・PEG/PPG-17/4 Dimethyl Ether・Xanthan Gum・Caffeine・Sapindus Mukorossi Peel Extract・Angelica Keiskei Leaf/Stem Extract・Camellia Sinensis Leaf Extract・Citrus Junos Seed Extract・Ziziphus Jujuba Fruit Extract・Eucheuma Serra/Grateloupia Sparsa/Saccharina Angustata/Ulva Linza/Undaria Pinnatifida Extract・Potentilla Erecta Root Extract・Polyquaternium-51・Saccharina Angustata/Undaria Pinnatifida Extract・Chlorella Vulgaris Extract・Beheneth-20・Batyl Alcohol・Alcohol・Succinoglycan・Trisodium EDTA・Sodium Citrate・Sodium Metaphosphate・BHT・Citric Acid・Sodium Metabisulfite・PPG-3 Dipivalate・Tocopherol・Phenoxyethanol・Fragrance・Iron Oxides・Can trigger reactions in some people with asthma.

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Details

Made byShiseido Americas Corporation
Active substanceAvobenzone, Homosalate, Octisalate, and Octocrylene
Strength1.295 g/50mL + 2.331 g/50mL + 2.331 g/50mL + 2.59 g/50mL
FormCream
RouteTopical
Packs1 JAR in 1 CARTON / 50 mL in 1 JAR
NDC58411-017

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

Other strengths and forms

2 products are sold under this name. Grouped by form; a number on a strength means several companies make it.

Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.