Votrient
200 mg · Tablet, Film Coated
- Prescription only
- Kinase Inhibitor
- Active substance
- Pazopanib Hydrochloride
- Made by
- Novartis Pharmaceuticals Corporation
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (Pazopanib). It describes the substance, not this exact product.
In vitro, pazopanib inhibited ligand-induced autophosphorylation of VEGFR-2, Kit, and PDGFR-β receptors.
In vivo, pazopanib inhibited VEGF-induced VEGFR-2 phosphorylation in mouse lungs, angiogenesis in a mouse model, and the growth of some human tumor xenografts in mice.
In vitro studies demonstrated that pazopanib is metabolized by CYP3A4 with a minor contribution from CYP1A2 and CYP2C8.
Effect of Food Systemic exposure to pazopanib is increased when administered with food.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-01-19
Safety of the active substance
From the US prescribing label for the same active substance (Pazopanib). It describes the substance, not this exact product.
WARNING: HEPATOTOXICITY Severe and fatal hepatotoxicity has been observed in clinical trials.
The most common adverse reactions in patients with STS (≥ 20%) are fatigue, diarrhea, nausea, decreased weight, hypertension, decreased appetite, vomiting, tumor pain, hair color changes, musculoskeletal pain, headache, dysgeusia, dyspnea, and skin hypopigmentation.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
Bulgaria8 matching products
European UnionNo exact match for this strength and form
Spain5 matching products
Details
| Made by | Novartis Pharmaceuticals Corporation |
|---|---|
| Active substance | Pazopanib Hydrochloride |
| Used in | Cancer treatments and immune-system medicines |
| Strength | 200 mg |
| Form | Tablet, Film Coated |
| Route | Oral |
| Packs | 120 TABLET, FILM COATED in 1 BOTTLE |
| NDC | 0078-1077 |
Source: NDC Directory · 2026-09-13 · not reviewed by a clinician
Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.