ATC RRespiratory systemWHO

Breathing, airways, allergiesand cough

8 151 medicines · 3 785 active substances · from the FDA National Drug Code Directory

Counted from the register

The group in figures

  • 8 151products listed in the register
  • 87%without prescription (7 072)
  • 4 068combination products — more than one substance

What the group contains

Anatomical main group R of the WHO ATC classification: “Respiratory system”. US records carry no ATC code: a product is here because the FDA pharmacologic class on its record maps to this group — not because of any judgement about who it is for.

1 279 marketing authorisation holders

  • Diphenhydramine Hcl
  • Cetirizine Hydrochloride
  • Guaifenesin
  • Dextromethorphan Hbr, Guaifenesin
  • Benzocaine

Source: FDA National Drug Code Directory, 2026-09-13. Counts computed by Mediclarum from that file.

The most common
substances

ACETAMINOPHEN1399 products · 678 aloneGUAIFENESIN1289 products · 667 aloneDEXTROMETHORPHAN HYDROBROMIDE854 products · 127 alone218323224180

and how often
they are combined

Numbers in the overlaps are products in the register that contain both substances (the centre: all three). Being sold together is not a statement that the substances are interchangeable, or that they should be combined.

Active substances in this group

Commonest first, by number of products in the register. Select one to see every product that contains it.

  1. 01Diphenhydramine Hcl604 products576 OTC
  2. 02Cetirizine Hydrochloride309 products296 OTC
  3. 03Guaifenesin268 products267 OTC
  4. 04Dextromethorphan Hbr, Guaifenesin229 products229 OTC
  5. 05Benzocaine212 products212 OTC
  6. 06Fexofenadine Hydrochloride181 products181 OTC
  7. 07Acetaminophen, Dextromethorphan Hbr, Guaifenesin, Phenylephrine Hcl155 products155 OTC
  8. 08Acetaminophen, Dextromethorphan Hbr, Doxylamine Succinate139 products139 OTC
  9. 09Colloidal Oatmeal133 products133 OTC
  10. 10Acetaminophen, Dextromethorphan Hbr, Phenylephrine Hcl132 products132 OTC
  11. 11Hydroxyzine Hydrochloride131 productsprescription only
  12. 12Albuterol Sulfate99 productsprescription only
  13. 13Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, and Phenylephrine Hydrochloride90 products90 OTC
  14. 14Glycerin87 products87 OTC
  15. 15Acetaminophen, Diphenhydramine Hcl86 products86 OTC
  16. 16Acetaminophen, Dextromethorphan Hbr, Doxylamine Succinate, Phenylephrine Hcl77 products77 OTC
  17. 17Dextromethorphan Hbr, Guaifenesin, Phenylephrine Hcl77 products77 OTC
  18. 18Benzonatate75 productsprescription only
  19. 19Acetaminophen, Dextromethorphan Hydrobromide73 products73 OTC
  20. 20Levocetirizine Dihydrochloride63 products31 OTC
  21. 21Montelukast Sodium61 productsprescription only
  22. 22Guaifenesin and Dextromethorphan Hbr59 products59 OTC
  23. 23Acetaminophen, Guaifenesin, and Phenylephrine Hydrochloride58 products58 OTC
  24. 24Dextromethorphan Hbr58 products58 OTC
  25. 25Dextromethorphan Hydrobromide and Guaifenesin55 products55 OTC
  26. 26Butalbital, Acetaminophen and Caffeine53 productsprescription only
  27. 27Hydroxyzine Pamoate51 productsprescription only
  28. 28Dextromethorphan Polistirex49 products49 OTC
  29. 29Olopatadine Hydrochloride49 products45 OTC
  30. 30Benztropine Mesylate48 productsprescription only
  31. 31Fluticasone Propionate and Salmeterol47 productsprescription only
  32. 32Caffeine46 products46 OTC
  33. 33Doxylamine Succinate45 products45 OTC
  34. 34Acetaminophen and Diphenhydramine Hydrochloride43 products43 OTC
  35. 35Guaifenesin and Pseudoephedrine Hcl43 products43 OTC
  36. 36Theophylline41 productsprescription only
  37. 37Guaifenesin, Dextromethorphan Hbr37 products37 OTC
  38. 38Oatmeal37 products37 OTC
  39. 39Candida Albicans35 products34 OTC
  40. 40Chlorpheniramine Maleate35 products35 OTC
  41. 41Dextromethorphan Hydrobromide, Guaifenesin, and Phenylephrine Hydrochloride33 products33 OTC
  42. 42Acetaminophen, Guaifenesin, Phenylephrine Hcl32 products32 OTC
  43. 43Dextromethorphan Hbr, Doxylamine Succinate32 products32 OTC
  44. 44Diphenhydramine Hydrochloride, Zinc Acetate32 products32 OTC
  45. 45Acetaminophen, Dextromethorphan Hydrobromide, and Phenylephrine Hydrochloride30 products30 OTC
  46. 46Acetaminophen, Dextromethorphan Hydrobromide, and Doxylamine Succinate29 products29 OTC
  47. 47Olopatadine Hydrochloride Ophthalmic29 products29 OTC
  48. 48Acetaminophen, Caffeine, Pyrilamine Maleate28 products28 OTC

Showing 48 of 2 152. Browse every substance A–Z

How this group is made

Each product is placed by the ATC code in its national register record (Bulgaria) or by the pharmacologic class the FDA assigned it (United States). Products without either are in no group rather than in a plausible one.

A group is not a diagnosis. Medicines are grouped by the class the regulator gave them. Which one suits you depends on things this page cannot know — ask a pharmacist or doctor.