Brompheniramine, Pseudoephedrine, Dextromethorphan
2 mg/5mL + 30 mg/5mL + 10 mg/5mL · Syrup
- Prescription only
- Sigma-1 Agonist
- Active substance
- Brompheniramine, Pseudoephedrine, Dextromethorphan
- Made by
- Ascend Laboratories, LLC
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
At a glance
Quoted from the official label · 2026-01-02
Sigma-1 Agonist
- For relief of coughs and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.
Adults and pediatric patients 12 years of age and over:: 10 mL (2 teaspoonfuls) every 4 hours.
Full directions ↓- Prescription only
- FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-01
Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed
What it is for
- For relief of coughs and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.
From the official label · 2026-01-02 · DailyMed
How it works
From this product’s own US prescribing label.
Brompheniramine maleate is a histamine antagonist, specifically an H 1 -receptor-blocking agent belonging to the alkylamine class of antihistamines.
Antihistamines appear to compete with histamine for receptor sites on effector cells.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-01-02
Do not take it if
- Hypersensitivity to any of the ingredients.
- Do not use in the newborn, in premature infants, in nursing mothers, or in patients with severe hypertension or severe coronary artery disease.
- Do not use dextromethorphan in patients receiving monoamine oxidase (MAOI) inhibitors (see PRECAUTIONS - Drug Interactions ).
- Antihistamines should not be used to treat lower respiratory tract conditions including asthma.
Quoted from the official label, section “Contraindications”.
How to take it
These directions are for this exact strength and form. Another one is different.
- Adults and pediatric patients 12 years of age and over:
- 10 mL (2 teaspoonfuls) every 4 hours.
- Children 6 to under 12 years of age: 5 mL (1 teaspoonful) every 4 hours.
- Children 2 to under 6 years of age: 2.5 mL (½ teaspoonful) every 4 hours.
- Infants 6 months to under 2 years of age: Dosage to be established by a physician.
- Do not exceed 6 doses during a 24-hour period.
Quoted from the official label, section “Dosage & Administration”.
Other warnings
Especially in infants and small children, antihistamines in overdosage may cause hallucinations, convulsions, and death. Antihistamines may diminish mental alertness. In the young child, they may produce excitation.
Quoted from the official label, section “Warnings”.
Pregnancy and breastfeeding
- Teratogenic Effects Pregnancy Category C Animal reproduction studies have not been conducted with brompheniramine maleate, pseudoephedrine hydrochloride and dextromethorphan hydrobromide syrup.
- It is also not known whether brompheniramine maleate, pseudoephedrine hydrochloride and dextromethorphan hydrobromide syrup can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.
- It should be given to a pregnant woman only if clearly needed.
- Reproduction studies of brompheniramine maleate (a component of brompheniramine maleate, pseudoephedrine hydrochloride and dextromethorphan hydrobromide syrup) in rats and mice at doses up to 16 times the maximum human doses have revealed no evidence of impaired fertility or harm to the fetus.
Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.
Other medicines
- Monoamine oxidase (MAO) inhibitors Hyperpyrexia, hypotension, and death have been reported coincident with the coadministration of MAO inhibitors and products containing dextromethorphan.
- In addition, MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines and may enhance the effect of pseudoephedrine.
- Concomitant administration of brompheniramine maleate, pseudoephedrine hydrochloride and dextromethorphan hydrobromide syrup and MAO inhibitors should be avoided (see CONTRAINDICATIONS ).
- Central nervous system (CNS) depressants Antihistamines have additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, antianxiety agents, etc.).
- Antihypertensive drugs Sympathomimetic may reduce the effects of antihypertensive drugs.
Quoted from the official label, section “Drug Interactions”.
Side effects
- The most frequent adverse reactions to brompheniramine maleate, pseudoephedrine hydrochloride and dextromethorphan hydrobromide syrup are:
- sedation; dryness of mouth, nose and throat; thickening of bronchial secretions; dizziness.
- Other adverse reactions may include:
- Dermatologic:
- Urticaria, drug rash, photosensitivity, pruritus.
- Cardiovascular System: Hypotension, hypertension, cardiac arrhythmias, palpitation.
- CNS:
- Disturbed coordination, tremor, irritability, insomnia, visual disturbances, weakness, nervousness, convulsions, headache, euphoria, and dysphoria.
- G.U.
- System : Urinary frequency, difficult urination.
- G.I.
- System : Epigastric discomfort, anorexia, nausea, vomiting, diarrhea, constipation.
- Respiratory System: Tightness of chest and wheezing, shortness of breath.
- Hematologic System: Hemolytic anemia, thrombocytopenia, agranulocytosis.
Quoted from the official label, section “Adverse Reactions”.
Details
| Made by | Ascend Laboratories, LLC |
|---|---|
| Active substance | Brompheniramine, Pseudoephedrine, Dextromethorphan |
| Used in | Breathing, airways, allergies and cough |
| Strength | 2 mg/5mL + 30 mg/5mL + 10 mg/5mL |
| Form | Syrup |
| Route | Oral |
| Packs | 473 mL in 1 BOTTLE · 118 mL in 1 BOTTLE |
| NDC | 67877-558 |
Source: NDC Directory · 2026-09-13 · not reviewed by a clinician
Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).