Diphenhydramine Hcl Oral Solution
12.5 mg/5mL · Solution
- Available without prescription
- Histamine-1 Receptor Antagonist
- Active substance
- Diphenhydramine Hcl Oral
- Made by
- Rising Pharma Holdings, Inc.
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (Diphenhydramine HCL). It describes the substance, not this exact product.
Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative effects.
Antihistamines appear to compete with histamine for cell receptor sites on effector cells.
Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-03
Safety of the active substance
From the US prescribing label for the same active substance (Diphenhydramine HCL). It describes the substance, not this exact product.
- Use in Neonates or Premature Infants This drug should not be used in neonates or premature infants.
- Use in Nursing Mothers Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
- Antihistamines are also contraindicated in the following conditions Hypersensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.
The most frequent adverse reactions are underscored.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
BulgariaNo exact match for this strength and form
CanadaNo exact match for this strength and form
Details
| Made by | Rising Pharma Holdings, Inc. |
|---|---|
| Active substance | Diphenhydramine Hcl Oral |
| Used in | Breathing, airways, allergies and cough |
| Strength | 12.5 mg/5mL |
| Form | Solution |
| Route | Oral |
| Packs | 100 CUP, UNIT-DOSE in 1 BOX, UNIT-DOSE / 5 mL in 1 CUP, UNIT-DOSE |
| NDC | 57237-317 |
Source: NDC Directory · 2026-09-13 · not reviewed by a clinician
Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).
Other strengths and forms
7 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- Solution7 products
12.5 mg/5mL4
12.5 mg/5mL · 4 companies
- Everpharm LLC
- Kesin Pharma Corporation
- Natco Pharma USA LLC
- Rising Pharma Holdings, Inc. · this page
25 mg/10mL3
25 mg/10mL · 3 companies
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.