Diphenhydramine Hydrochloride
50 mg · Capsule
- Available without prescription
- Histamine-1 Receptor Antagonist
- Active substance
- Diphenhydramine Hydrochloride
- Made by
- Richmond Pharmaceuticals, Inc.
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet
How it works
From the US prescribing label for the same active substance (Diphenhydramine HCL). It describes the substance, not this exact product.
Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative effects.
Antihistamines appear to compete with histamine for cell receptor sites on effector cells.
Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-03
Safety of the active substance
From the US prescribing label for the same active substance (Diphenhydramine HCL). It describes the substance, not this exact product.
- Use in Neonates or Premature Infants This drug should not be used in neonates or premature infants.
- Use in Nursing Mothers Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
- Antihistamines are also contraindicated in the following conditions Hypersensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.
The most frequent adverse reactions are underscored.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
BulgariaNo exact match for this strength and form
Canada15 matching products
- SLEEP AID EXTRA STRENGTH 50 mg · capsuleWithout prescription2 makers
- ALLERGY CAPSULES EXTRA STRENGTH 50 mg · capsuleWithout prescription
- DIPHENHYDRAMINE HYDROCHLORIDE 50 mg · capsuleWithout prescription
- DORMIPHEN EXTRA-FORT CAPSULE 50 mg · capsuleWithout prescription
- EXTRA STRENGTH ALLERGY FORMULA LIQUID CAPSULES 50 mg · capsuleWithout prescription
- EXTRA STRENGTH DORMEX CAPSULES 50 mg · capsuleWithout prescription
- EXTRA STRENGTH NIGHTTIME ALLERGY LIQUID GEL CAPSULES 50 mg · capsuleWithout prescription
- EXTRA STRENGTH NYTOL QUICKGELS 50 mg · capsuleWithout prescription
Details
| Made by | Richmond Pharmaceuticals, Inc. |
|---|---|
| Active substance | Diphenhydramine Hydrochloride |
| Used in | Breathing, airways, allergies and cough |
| Strength | 50 mg |
| Form | Capsule |
| Route | Oral |
| Packs | 100 CAPSULE in 1 BOTTLE · 1000 CAPSULE in 1 BOTTLE |
| NDC | 54738-116 |
Source: NDC Directory · 2026-09-13 · not reviewed by a clinician
Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).
Other strengths and forms
65 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- Capsule21 products
50 mg5
50 mg · 5 companies
- Advance Pharmaceutical Inc.
- Epic Pharma, LLC
- Major Pharmaceuticals
- Richmond Pharmaceuticals Inc.
- Richmond Pharmaceuticals, Inc. · this page
- Injection11 products
- Capsule, Liquid Filled8 products
25 mg3
- Injection, Solution7 products
Show all forms · 8 forms
- Solution6 products
12.5 mg/5mL3
12.5 mg/5mL · 3 companies
25 mg/10mL3
25 mg/10mL · 3 companies
- Tablet6 products
25 mg5
- 50 mg
- Tablet, Film Coated4 products
25 mg4
- Tablet, Coated2 products
25 mg2
25 mg · 2 companies
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.