Leader 8hr Arthritis Pain Relief
650 mg · Tablet, Film Coated, Extended Release
- Available without prescription
- Active substance
- Acetaminophen
- Made by
- Cardinal Health 110, LLC. dba Leader
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
At a glance
Quoted from the official label · 2025-11-10
Pain reliever/fever reducer
- Minor pain of arthritis
- Muscular aches
- Backache
- Premenstrual and menstrual cramps
- The common cold
Take 2 caplets every 8 hours with water
do not take more than 6 caplets in 24 hours
Full directions ↓With any other drug containing acetaminophen (prescription or nonprescription).
All warnings ↓- Sold without a prescription
- FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed
What it is for
temporarily relieves minor aches and pains due to:
- minor pain of arthritis
- muscular aches
- backache
- premenstrual and menstrual cramps
- the common cold
- headache
- toothache
- temporarily reduces fever
From the official label · 2025-11-10 · DailyMed
How it works
From the US prescribing label for the same active substance (Acetaminophen). It describes the substance, not this exact product.
The precise mechanism of the analgesic and antipyretic properties of acetaminophen is not established but is thought to primarily involve central actions.
With therapeutic doses, NAPQI undergoes rapid conjugation with glutathione and is then further metabolized to form cysteine and mercapturic acid conjugates.
Acetaminophen metabolites are mainly excreted in the urine.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-28
Do not take it if
- with any other drug containing acetaminophen (prescription or nonprescription).
- If you are not sure whether a drug contains acetaminophen,
- ask a doctor or pharmacist.
- if you are allergic to acetaminophen or any of the inactive ingredients in this product
Quoted from the official label, section “OTC — Do Not Use”.
How to take it
These directions are for this exact strength and form. Another one is different.
- do not take more than directed (see overdose warning) adults
- take 2 caplets every 8 hours with water
- swallow whole; do not crush, chew, split or dissolve
- do not take more than 6 caplets in 24 hours
- do not use for more than 10 days unless directed by a doctor under 18 years of age
- ask a doctor
Quoted from the official label, section “Dosage & Administration”.
Ask a doctor first if
liver disease
Quoted from the official label, section “OTC — Ask Doctor”.
Ask a pharmacist first if
you are taking the blood thinning drug warfarin
Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.
Stop and get help if
- pain gets worse or lasts more than 10 days
- fever gets worse or lasts more than 3 days
- new symptoms occur
- redness or swelling is present These could be signs of a serious condition.
Quoted from the official label, section “OTC — Stop Use”.
Other warnings
- Liver warning:
- This product contains acetaminophen. Severe liver damage may occur
- if you take
- more than 6 caplets in 24 hours, which is the maximum daily amount
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product Allergy alert:
- Acetaminophen may cause severe skin reactions. Symptoms may include:
- skin reddening
- blisters
- rash If a skin reaction occurs, stop use and seek medical help right away. Do not use
- Ask a doctor before use
- if you have liver disease
- Ask a doctor or pharmacist before use
- if you are taking the blood thinning drug warfarin
- Stop use and
- ask a doctor if
- redness or swelling is present These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use.
- Keep out of reach of children. Overdose warning:
Quoted from the official label, section “Warnings”.
Pregnancy and breastfeeding
If pregnant or breast-feeding, ask a health professional before use.
Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.
Keep away from children
- Overdose warning:
- In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for
- adults as well as for children even
- if you do not notice any signs or symptoms.
Quoted from the official label, section “OTC — Keep Out of Reach of Children”.
How to store it
- store at 20-25°C (68-77°F)
- do not use if printed foil under cap is broken or missing
- meets the requirements of USP Dissolution Test 4
Quoted from the official label, section “Storage and Handling”.
What kind of medicine it is
Pain reliever/fever reducer
Quoted from the official label, section “OTC — Purpose”.
Other ingredients
Relevant if you react to a dye, a preservative, lactose or gluten.
carnauba wax, colloidal silicon dioxide, croscarmellose sodium, hypromellose, magnesium stearate, maltodextrin, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone, pregelatinized starch, stearic acid, titanium dioxide
Quoted from the official label, section “Inactive Ingredients”.
Questions about this product
1-800-719-9260
Quoted from the official label, section “OTC — Questions”.
Ingredients people check for
Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.
- Titanium dioxide
titanium dioxide
A whitening agent no longer allowed in food in the EU (E171).
Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.
Every version of this medicine (109)
The same active substance, strength and kind of form, from every company that sells it — with what each label lists.
Showing 80 of 80 (the first 80 are listed)
- Leader 8hr Arthritis Pain ReliefThis oneWithout prescriptionCardinal Health 110, LLC. dba LeaderTitanium dioxide
- 8hr Muscle Aches and PainWithout prescriptionAAA Pharmaceutical, Inc.Names none of these
- Arthritis PainWithout prescriptionAAA Pharmaceutical, Inc.Names none of these
- Amazon Basic Care AcetaminophenWithout prescriptionAmazon.com Services LLCTitanium dioxide
- Basic Care AcetaminophenWithout prescriptionAmazon.com Services LLCTitanium dioxide
- AcetaminophenWithout prescriptionAmerican Health PackagingTitanium dioxide
- Care One Arthritis Pain ReliefWithout prescriptionAmerican Sales CompanyTitanium dioxide
- Careone 8 Hour Pain ReliefWithout prescriptionAmerican Sales CompanyTitanium dioxide
- Arthritis PainWithout prescriptionAMERIFOODS TRADING COMPANYNames none of these
- Good Neighbor Pharmacy Menstrual Pain ReliefWithout prescriptionAmerisource BergenTitanium dioxide
- 8 Hour Arthritis PainWithout prescriptionAMERISOURCE BERGENNames none of these
- 8 Hour Pain ReliefWithout prescriptionAMERISOURCE BERGENNames none of these
- Good Sense Pain Relief Arthritis PainWithout prescriptionASCLEMED USA INC.Titanium dioxide
- AcetaminophenWithout prescriptionAurohealth LLCTitanium dioxide
- Midol Long Lasting ReliefWithout prescriptionBayer HealthCare LLC.Titanium dioxide
- Dolo - Neurobion Acetaminophen Max Extended-Release 650 MgWithout prescriptionBENARD INDUSTRIES INCNames none of these
- AcetaminophenWithout prescriptionBetter Living Brands, LLCTitanium dioxide
- Arthritis PainWithout prescriptionBETTER LIVING BRANDS, LLCTitanium dioxide
- AcetaminophenWithout prescriptionBi-MartNames none of these
- AcetaminophenWithout prescriptionBluePoint LaboratoriesTitanium dioxide
- AcetaminophenWithout prescriptionBryant Ranch PrepackNames none of these
- Good Sense Pain Relief Arthritis PainWithout prescriptionBryant Ranch PrepackTitanium dioxide
- Arthritis Pain ReliefWithout prescriptionCHAIN DRUG CONSORTIUMNo ingredient list on the stored label
- 8 Hour Pain ReliefWithout prescriptionCHAIN DRUG MARKETING ASSOCIATION INCNames none of these
- AcetaminophenWithout prescriptionCHAIN DRUG MARKETING ASSOCIATION INCNames none of these
- 8 Hour Arthritis PainWithout prescriptionCHAIN DRUG MARKETING ASSOCIATION, INC.Names none of these
- 8 Hour Pain ReliefWithout prescriptionCHAIN DRUG MARKETING ASSOCIATION, INC.Names none of these
- 8 Hr Muscle Aches and PainWithout prescriptionCVS PharmacyTitanium dioxide
- AcetaminophenWithout prescriptionCVS PharmacyGelatinTitanium dioxide
- AcetaminophenWithout prescriptionCVS PHARMACY iNCNames none of these
- AcetaminophenWithout prescriptionCVS Pharmacy, Inc.Titanium dioxide
- 8 Hr Arthritis PainWithout prescriptionCVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATEDTitanium dioxide
- Arthritis PainWithout prescriptionDISCOUNT DRUG MARTNames none of these
- Dg Health 8 Hour Pain ReliefWithout prescriptionDolgencorp IncTitanium dioxide
- Dg Health 8 Hr Arthritis Pain ReliefWithout prescriptionDolgencorp IncTitanium dioxide
- 8 Hr Arthritis Pain ReliefWithout prescriptionDOLGENCORP, INC.Titanium dioxide
- 8 Hr Pain ReliefWithout prescriptionDOLGENCORP, INC.Titanium dioxide
- 8 Hr Arthritis PainWithout prescriptionDr. Reddy's Laboratories Inc.Names none of these
- AcetaminophenWithout prescriptionFAMILY DOLLARNames none of these
- Acetaminophen 650mgWithout prescriptionForreal Pharmaceuticals, LLCTitanium dioxide
- 8hr Arthritis PainWithout prescriptionFSA STORE INC.Names none of these
- 8hr Muscle Aches and PainWithout prescriptionFSA STORE INC.Names none of these
- AcetaminophenWithout prescriptionGERI-CARE PHARMACEUTICAL CORPNames none of these
- AcetaminophenWithout prescriptionGranules India LimitedNames none of these
- AcetaminophenWithout prescriptionGranules Pharmaceuticals Inc.Names none of these
- AcetaminophenWithout prescriptionGranules USA, Inc.Names none of these
- Arthritis PainWithout prescriptionGrocery Outlet, Inc.Names none of these
- Pain Relief 8 HrWithout prescriptionH E BTitanium dioxide
- 8hr Arthritis PainWithout prescriptionHARRIS TEETERNames none of these
- HebWithout prescriptionHEBNames none of these
- Arthritis PainWithout prescriptionHYVEE INCNames none of these
- Pain ReliefWithout prescriptionHYVEE INCNames none of these
- Tylenol 8 Hr Arthritis PainWithout prescriptionKenvue Brands LLCNames none of these
- Tylenol 8 Hr Arthritis PainWithout prescriptionKenvue Brands LLCTitanium dioxide
- Tylenol 8 Hr Muscle Aches and PainWithout prescriptionKenvue Brands LLCNames none of these
- Tylenol 8hrWithout prescriptionKenvue Brands LLCTitanium dioxide
- 8 Hour Pain ReliefWithout prescriptionKROGER COMPANYTitanium dioxide
- AcetaminophenWithout prescriptionKROGER COMPANYTitanium dioxide
- Arthritis Pain ReliefWithout prescriptionKROGER COMPANYTitanium dioxide
- Good Sense Pain ReliefWithout prescriptionL. Perrigo CompanyTitanium dioxide
- Good Sense Pain Relief Arthritis PainWithout prescriptionL. Perrigo CompanyTitanium dioxide
- AcetaminophenWithout prescriptionLEADER/ Cardinal Health 110, IncNames none of these
- 8hr Arthritis Pain ReliefWithout prescriptionLEADER/ Cardinal Health 110, Inc.Titanium dioxide
- 8hr Muscle Aches and Pain ReliefWithout prescriptionLEADER/ Cardinal Health 110, Inc.Titanium dioxide
- Acetaminophen Extended-ReleaseWithout prescriptionMagno-Humphries, Inc.Names none of these
- 8hr Arthritis Pain ReliefWithout prescriptionMajor PharmaceuticalsTitanium dioxide
- Major AcetaminophenWithout prescriptionMajor PharmaceuticalsTitanium dioxide
- AcetaminophenWithout prescriptionMAJOR PHARMACEUTICALSNames none of these
- 8 Hour Arthritis PainWithout prescriptionMARC GLASSMAN, INC.Names none of these
- Acetaminophen Extended-Release Tablets, 650 MgWithout prescriptionMARKSANS PHARMA LIMITEDTitanium dioxide
- AcetaminophenWithout prescriptionMedline Industries, LPTitanium dioxide
- Arthritis Pain ReliefWithout prescriptionMeijerNames none of these
- Arthritis Pain ReliefWithout prescriptionMeijer Distribution IncTitanium dioxide
- Pain ReliefWithout prescriptionMeijer Distribution IncTitanium dioxide
- AcetaminophenWithout prescriptionMEIJER DISTRIBUTION INCNames none of these
- AcetaminophenWithout prescriptionMEIJER, INC.Names none of these
- AcetaminophenWithout prescriptionNCS HealthCare of KY, LLC dba Vangard LabsNames none of these
- Atamel ForteWithout prescriptionOPMX LLCTitanium dioxide
- Arthritis Pain ReliefWithout prescriptionPublix Super Markets IncTitanium dioxide
- AcetaminophenWithout prescriptionRETAIL BUSINESS SERVICES,LLC.Names none of these
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
Spain40 matching products
- ANTIDOL 650 mg · comprimidoWithout prescription2 makers
- PARACETAMOL CINFA 650 mg · comprimido2 makers
- CALTHEK 650 mg comprimidos · comprimidoWithout prescription
- DIFENATIL 650 mg · comprimidoWithout prescription
- DOLOSTOP 650 MG · comprimidoWithout prescription
- EFFERALDOL 650 mg · comprimidoWithout prescription
- FEBRECTAL 650 mg paracetamol · comprimidoWithout prescription
- GELOCATIL 650 mg paracetamol · comprimidoWithout prescription
Canada11 matching products
- ARTHRITIS PAIN RELIEF 650 mg · tablet (extended-release)Without prescription2 makers
- MUSCLE ACHES AND BODY PAIN RELIEF 650 mg · tablet (extended-release)Without prescription2 makers
- ACETAMINOPHEN 650 mg · tablet (extended-release)Without prescription
- ACETAMINOPHEN ARTHRITIS PAIN 650 mg · tablet (extended-release)Without prescription
- ARTHRITIS PAIN EXTENDED RELIEF 650 mg · tablet (extended-release)Without prescription
- MUSCLE & BODY 650 mg · tablet (extended-release)Without prescription
- MUSCLE ACHES & BODY PAIN 650 mg · tablet (extended-release)Without prescription
- TYLENOL ARTHRITIS PAIN 650 mg · tablet (extended-release)Without prescription
Netherlands2 matching products
Details
| Made by | Cardinal Health 110, LLC. dba Leader |
|---|---|
| Active substance | Acetaminophen |
| Strength | 650 mg |
| Form | Tablet, Film Coated, Extended Release |
| Route | Oral |
| Packs | 1 BOTTLE in 1 CARTON / 225 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE |
| NDC | 70000-0736 |
Source: NDC Directory · 2026-09-13 · not reviewed by a clinician
Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.