Nicotine
21 mg/24h · Patch
- Available without prescription
- Cholinergic Nicotinic Agonist
- Active substance
- Nicotine
- Made by
- Rugby Laboratories
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
At a glance
Quoted from the official label · 2024-06-05
- Class III Ongoing · 2026-05-14 — Failed Impurities/Degradation Specifications: Elevated levels of oxidative-related impurities, exceeding shelf-life specifications during stability testing of individual units.Using the product is unlikely to cause harm, but it breaks a rule.
A recall usually covers specific lots. Check the lot number on your pack against the notice, and ask your pharmacist before you stop a medicine. FDA recalls
Stop smoking aid
- Reduces withdrawal symptoms, including nicotine craving, associated with quitting smoking.
Weeks 1 thru 4 Weeks 5 and 6 Weeks 7 and 8 Step 1 Step 2 Step 3 use one 21 mg patch/day use one 14 mg patch/day use one 7 mg patch/day
Full directions ↓- Sold without a prescription
Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed
What it is for
- reduces withdrawal symptoms, including nicotine craving, associated with quitting smoking.
From the official label · 2024-06-05 · DailyMed
How it works
From the US prescribing label for the same active substance (Nicotrol). It describes the substance, not this exact product.
Pharmacologic Action Nicotine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain.
Two types of central nervous system effects are believed to be the basis of nicotine's positively reinforcing properties.
The major site for the metabolism of nicotine is the liver.
About 10% of the nicotine absorbed is excreted unchanged in the urine.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2025-05-29
How to take it
These directions are for this exact strength and form. Another one is different.
- If you are under 18 years of age,
- ask a doctor before use before using this product, read the enclosed self-help guide for complete directions and other information begin using the patch on your quit day
- If you smoke more than 10 cigarettes per day , use the following schedule below:
- Weeks 1 thru 4 Weeks 5 and 6 Weeks 7 and 8 Step 1 Step 2 Step 3 use one 21 mg patch/day use one 14 mg patch/day use one 7 mg patch/day
- if you smoke 10 or less cigarettes per day, start with Step 2 for 6 weeks, then Step 3 for 2 weeks apply one new patch every 24 hours on skin that is dry, clean, and hairless remove backing from patch and immediately press onto skin.
- Hold for 10 seconds. wash hands after applying or removing patch.
- Save pouch to use for patch disposal.
- Dispose of the used patches by folding sticky ends together and putting in pouch. the used patch should be removed and a new one applied to a different skin site at the same time each day
- if you have vivid dreams, you may remove the patch at bedtime and apply a new one in the morning do not wear more than one patch at a time do not cut patch in half or into smaller pieces do not leave patch on for more than 24 hours because it may irritate your skin and loses strength after 24 hours it is important to complete treatment.
- If you feel you need to use the patch for a longer period to keep from smoking, talk to your health care provider.
Quoted from the official label, section “Dosage & Administration”.
Ask a doctor first if
- heart disease, recent heart attack, or irregular heartbeat.
- Nicotine can increase your heart rate. high blood pressure not controlled with medication.
- Nicotine can increase your blood pressure. an allergy to adhesive tape or have skin problems, because
- you are more likely to get rashes. stomach ulcer or diabetes history of seizures
Quoted from the official label, section “OTC — Ask Doctor”.
Ask a pharmacist first if
you are using a non-nicotine stop smoking drug taking a prescription medicine for depression or asthma. Your prescription dose may need to be adjusted.
Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.
Stop and get help if
- skin redness caused by the patch does not go away after four days, or if your skin swells, or
- you get a rash irregular heartbeat or palpitations occur
- you get symptoms of nicotine overdose, such as nausea, vomiting, dizziness, weakness, and rapid heartbeat
- you have symptoms of an allergic reaction (such as difficulty breathing or rash)
Quoted from the official label, section “OTC — Stop Use”.
Other warnings
- Ask a doctor before use
- if you have heart disease, recent heart attack, or irregular heartbeat.
- Ask a doctor or pharmacist before use
- if you are using a non-nicotine stop smoking drug taking a prescription medicine for depression or asthma.
- When using this product
- if you have vivid dreams or other sleep disturbances, remove the patch at bedtime
- Stop use and
- ask a doctor if skin redness caused by the patch does not go away after four days, or if your skin swells, or
- Keep out of reach of children and pets Used patches have enough nicotine to poison children and pets.
- if you have vivid dreams or other sleep disturbances, remove the patch at bedtime
Quoted from the official label, section “Warnings”.
Pregnancy and breastfeeding
- If you are pregnant or breast feeding, only use this medicine on the advice of your health care provider.
- Smoking can seriously harm your child.
- Try to stop smoking without using any nicotine replacement medicine.
- This medicine is believed to be safer than smoking.
- However, the risks to your child from this medicine are not fully known.
Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.
Keep away from children
- and pets Used patches have enough nicotine to poison children and pets.
- If swallowed, get medical help or contact a Poison Control Center 1-800-222-1222 right away.
- Save pouch to use for patch disposal.
- Dispose of the used patches by folding sticky ends together and putting in pouch.
Quoted from the official label, section “OTC — Keep Out of Reach of Children”.
What kind of medicine it is
Stop smoking aid
Quoted from the official label, section “OTC — Purpose”.
Other ingredients
Relevant if you react to a dye, a preservative, lactose or gluten.
acrylate adhesive, polyester, silicone adhesive
Quoted from the official label, section “Inactive Ingredients”.
Questions about this product
Comments or questions? 1-877-748-1970
Quoted from the official label, section “OTC — Questions”.
Ingredients people check for
Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.
This label’s list of inactive ingredients names none of: lactose, wheat or gluten, colour dyes, sugars, sugar alcohols, alcohol (ethanol), aspartame (phenylalanine), gelatin, peanut oil, soy, parabens, sulfites, titanium dioxide.
Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.
Every version of this medicine (22)
The same active substance, strength and kind of form, from every company that sells it — with what each label lists.
Showing 22 of 22
- NicotineThis oneWithout prescriptionRugby LaboratoriesNames none of these
- NicotineWithout prescriptionA-S Medication SolutionsNames none of these
- Nicotine Transdermal SystemWithout prescriptionA-S Medication SolutionsNames none of these
- Nicotine Transdermal System Step 1Without prescriptionAmerisourceBergen Drug CorporationNames none of these
- Nicotine Transdermal System Step 1Without prescriptionCARDINAL HEALTH 110, LLC. DBA LEADERNames none of these
- Nicotine Transdermal System Step 1Without prescriptionChain Drug Marketing Association INCNames none of these
- Nicotine Transdermal System Step 1Without prescriptionCVS PharmacyNames none of these
- Nicotine Transdermal System Step 1Without prescriptionDOLGENCORP, LLCNames none of these
- Nicotine Transdermal System Step 1Without prescriptionDr. Reddy's Laboratories Inc.Names none of these
- Nicotine Transdermal System Step 1Without prescriptionGolden State Medical Supply, Inc.Names none of these
- Nicoderm CqWithout prescriptionHaleon US Holdings LLCNames none of these
- NicotineWithout prescriptionMeijer, Inc.Names none of these
- Nicotine Transdermal System Step 1Without prescriptionRite Aid CorporationNames none of these
- Nicotine Transdermal System Step 1Without prescriptionRugby LaboratoriesNo ingredient list on the stored label
- Nicotine Transdermal SystemWithout prescriptionSam's West IncNames none of these
- NicotineWithout prescriptionStrategic Sourcing Services LLCNames none of these
- Nicotine Transdermal System Step 1Without prescriptionStrategic Sourcing Services LLCNames none of these
- Nicotine Transdermal SystemWithout prescriptionTarget CorporationNames none of these
- Nicotine Transdermal System Step 1Without prescriptionThe Kroger Co.Names none of these
- Nicotine Transdermal System Step 1Without prescriptionTopco Associates LLCNames none of these
- Nicotine Transdermal SystemWithout prescriptionWal-Mart Stores IncNames none of these
- Nicotine Transdermal System Step 1Without prescriptionWalgreens CompanyNames none of these
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
FranceNo exact match for this strength and form
NetherlandsNo exact match for this strength and form
Details
| Made by | Rugby Laboratories |
|---|---|
| Active substance | Nicotine |
| Used in | Pain, sleep, mood, epilepsy and the brain |
| Strength | 21 mg/24h |
| Form | Patch |
| Route | Transdermal |
| Packs | 7 POUCH in 1 CARTON / 1 h in 1 POUCH · 28 POUCH in 1 CARTON / 1 h in 1 POUCH |
| NDC | 0536-5896 |
Source: NDC Directory · 2026-09-13 · not reviewed by a clinician
Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).
Other strengths and forms
85 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- Gum, Chewing39 products
- Lozenge36 products
- Patch10 products
7 mg/24h3
7 mg/24h · 3 companies
14 mg/24h3
14 mg/24h · 3 companies
21 mg/24h4
21 mg/24h · 4 companies
- A-S Medication Solutions
- Meijer, Inc.
- Rugby Laboratories · this page
- Strategic Sourcing Services LLC
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.