Mediclarum
Medicine guide

Sodium Sulfacetamide 9% and Sulfur 4.5% Cleanser

90 mg/g + 45 mg/g · Liquid

  • Prescription only
  • Sulfonamide Antibacterial
Made by
Method Pharmaceuticals

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2026-02-12

What it is

Sulfonamide Antibacterial

Used for
  • SODIUM SULFACETAMIDE 9% - SULFUR 4.5% CLEANSER is indicated for use in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.
Do not take it if

SODIUM SULFACETAMIDE 9% - SULFUR 4.5% CLEANSER is contraindicated for use by patients having known hypersensitivity to sulfonamides, sulfur or any other component of this preparation.

All warnings ↓
Good to know
  • Prescription only
  • FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
47other products contain Sulfacetamide Sodium, Sulfur — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

  • SODIUM SULFACETAMIDE 9% - SULFUR 4.5% CLEANSER is indicated for use in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.

From the official label · 2026-02-12 · DailyMed

How it works

From this product’s own US prescribing label.

Sodium sulfacetamide exerts a bacteriostatic effect against sulfonamide sensitive Gram-positive and Gram-negative microorganisms commonly isolated from secondary cutaneous pyogenic infections.

It acts by restricting the synthesis of folic acid required by bacteria for growth, by its competition with para-aminobenzoic acid.

Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-02-12

Do not take it if

  • SODIUM SULFACETAMIDE 9% - SULFUR 4.5% CLEANSER is contraindicated for use by patients having known hypersensitivity to sulfonamides, sulfur or any other component of this preparation.
  • SODIUM SULFACETAMIDE 9% - SULFUR 4.5% CLEANSER is not to be used by patients with kidney disease.

Quoted from the official label, section “Contraindications”.

How to take it

These directions are for this exact strength and form. Another one is different.

  • Wash affected area once or twice daily, or as directed by your physician.
  • Avoid contact with eyes or mucous membranes.
  • Wet skin and liberally apply to areas to be cleansed, massage gently into skin for 10-20 seconds working into a full lather, rinse thoroughly and pat dry.
  • If drying occurs, it may be controlled by rinsing cleanser off sooner or using less often.
  • See label booklet for Full Prescribing Information.

Quoted from the official label, section “Dosage & Administration”.

Other warnings

  • Although it is rare, sensitivity to sodium sulfacetamide may occur.
  • Therefore, caution and careful supervision should be observed when prescribing this drug for patients who may be prone to hypersensitivity to topical sulfonamides.
  • Systemic toxic reactions such as agranulocytosis, acute hemolytic anemia, purpura hemorrhagica, drug fever, jaundice, and contact dermatitis indicate hypersensitivity to sulfonamides.
  • Particular caution should be employed if areas of denuded or abraded skin are involved.
  • FOR EXTERNAL USE ONLY.
  • NOT FOR INTRAVAGINAL OR OPHTHALMIC USE.
  • (KEEP AWAY FROM EYES).
  • KEEP OUT OF REACH OF CHILDREN.
  • In case of accidental ingestion contact a poison control center immediately.
  • Keepcontainer tightly closed.
  • Precaution General:
  • If irritation develops, use of the product should be discontinued and appropriate therapy instituted.
  • Patients should be carefully observed for possible local irritation or sensitization during long-term therapy.
  • The object of this therapy is to achieve desquamation without irritation, but sodium sulfacetamide and sulfur can cause reddening and scaling of the epidermis.
  • These side effects are not unusual in the treatment of acne vulgaris, but patients should be cautioned about the possibility.
  • Information for Patients : Avoid contact with eyes, eyelids, lips and mucous membranes.
  • If accidental contact occurs, rinse with water.
  • If excessive irritation develops, discontinue use and consult your physician.
  • Carcinogenesis, Mutagenesis and Impairment of Fertility :
  • Long-term studies in animals have not been performed to evaluate carcinogenic potential.
  • Pregnancy: Category C.
  • Animal reproduction studies have not been conducted with Sodium Sulfacetamide 9% & Sulfur 4.5% Cleanser.
  • It is also not known whether Sodium Sulfacetamide 9% & Sulfur 4.5% Cleanser can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.
  • Sodium Sulfacetamide 9% & Sulfur 4.5% Cleanser should be given to a pregnant woman only if clearly needed.
  • Nursing Mothers:
  • It is not known whether sodium sulfacetamide is excreted in the human milk following topical use of Sodium Sulfacetamide 9% & Sulfur 4.5% Cleanser.
  • However, small amounts of orally administered sulfonamides have milk.
  • In view of this and because many drugs are excreted in human milk, caution should be exercised when Sodium Sulfacetamide 9% & Sulfur 4.5% Cleanser is administered to a nursing woman.
  • Pediatric Use:
  • Safety and effectiveness in
  • children under the age of 12 have not been established.

Quoted from the official label, section “Warnings”.

Side effects

Adverse Reaction Although rare, sodium sulfacetamide may cause local irritation. Call your doctor for medical advice about side effects. To report a serious adverse event or obtain product information, call 1-877-250-3427.

Quoted from the official label, section “Adverse Reactions”.

What it looks like and how it is packed

  • Store at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (between 59°F and 86°F).
  • Brief exposure to temperatures up to 40°C (104°F) may be tolerated provided the mean kinetic temperature does not exceed 25°C (77°F); however, such exposure should be minimized.
  • NOTICE: Protect from freezing and excessive heat.
  • The product may tend to darken slightly on storage.
  • Slight discoloration does not impair the efficacy or safety of the product.
  • Keep bottle tightly closed.
  • Occasionally, a slight discoloration of fabric may occur when an excessive amount of the product is used and comes in contact with white fabrics.
  • This discoloration, however, presents no problem, as it is readily removed by ordinary laundering without bleaches.
  • This bottle is not filled to the top but does contain 16 fl oz of product as identified on the front panel of the bottle.

Quoted from the official label, section “How Supplied”.

What is in it

  • Each gram of sodium sulfacetamide 9% and sulfur 4.5% cleanser contains 90 mg of sodium sulfacetamide and 45 mg of sulfur in a cleanser containing Aloe Vera leaf Extract, Butylated Hydroxytoluene, Cetyl Alcohol, Citric Acid, Cocamidopropyl Betaine, Disodium EDTA, Glycerin, Glyceryl Stearate SE, PEG-100 Stearate, Phenoxyethanol, Purified Water, Sodium laureth sulfate, Sodium Thiosulfate, Stearyl alcohol, Triacetin, Xanthan Gum.
  • Sodium sulfacetamide is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent.
  • Sodium sulfacetamide is C 8 H 9 N 2 NaO 3S·H2O with molecular weight of 254.24.
  • Chemically, it is N-[(4-aminophenyl)sulfonyl]-acetamide, monosodium salt, monohydrate.
  • The structural formula is: sec

Quoted from the official label, section “Description”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

The stored label for this product has no list of inactive ingredients. The list on the pack is the one to check.

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (3)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

Showing 3 of 3

Details

Made byMethod Pharmaceuticals
Active substanceSulfacetamide Sodium, Sulfur
Used inAntibiotics, antivirals and antifungals taken into the body
Strength90 mg/g + 45 mg/g
FormLiquid
RouteTopical
Packs454 g in 1 BOTTLE, PLASTIC
NDC58657-474

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

Report wrong or outdated information on this page

Other strengths and forms

2 products are sold under this name. Grouped by form; a number on a strength means several companies make it.

  • Liquid2 products
    • 90 mg/g + 45 mg/g2

      90 mg/g + 45 mg/g · 2 companies

Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

Avar100 mg/g + 50 mg/gPrescription onlyEmulsion Mission Pharmacal Company · Sulfacetamide Sodium, SulfurAvar Ls100 mg/g + 20 mg/gPrescription onlyEmulsion Mission Pharmacal Company · Sulfacetamide Sodium, SulfurAvar-E100 mg/g + 50 mg/gPrescription onlyCream Mission Pharmacal Company · Sulfacetamide Sodium, SulfurAvar-E Green100 mg/g + 50 mg/gPrescription onlyCream Mission Pharmacal Company · Sulfacetamide Sodium, SulfurAvar-E Ls100 mg/g + 20 mg/gPrescription onlyCream Mission Pharmacal Company · Sulfacetamide Sodium, SulfurPlexion98 mg/g + 48 mg/gPrescription onlyLiquid Cintex Services, LLC · Sulfacetamide Sodium, Sulfur

See every product with Sulfacetamide Sodium, Sulfur