Medicine guide

Acetaminophen and Ibuprofen

125 mg + 250 mg · Tablet, Film Coated

  • Available without prescription
  • Nonsteroidal Anti-inflammatory Drug
Made by
AMERISOURCE BERGEN

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2025-05-15

What it is

Pain reliever Pain reliever

Used for
  • Headache toothache backache menstrual cramps muscular aches minor pain of arthritis
How to take it

Take 2 caplets every 8 hours while symptoms persist children under 12 years

do not take more than 6 caplets in 24 hours, unless directed by a doctor

Full directions ↓
Do not take it if

With any other drug containing acetaminophen (prescription or nonprescription).

All warnings ↓
Good to know
  • Sold without a prescription
  • FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
26other products contain Acetaminophen and Ibuprofen — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

temporarily relieves minor aches and pains due to:

  • headache toothache backache menstrual cramps muscular aches minor pain of arthritis

From the official label · 2025-05-15 · DailyMed

Do not take it if

  • with any other drug containing acetaminophen (prescription or nonprescription).
  • If you are not sure whether a drug contains acetaminophen,
  • ask a doctor or pharmacist
  • if you have ever had an allergic reaction to acetaminophen or any other pain reliever right before or after heart surgery

Quoted from the official label, section “OTC — Do Not Use”.

How to take it

These directions are for this exact strength and form. Another one is different.

  • do not take more than directed adults and children 12 years and over
  • take 2 caplets every 8 hours while symptoms persist children under 12 years
  • ask a doctor
  • do not take more than 6 caplets in 24 hours, unless directed by a doctor

Quoted from the official label, section “Dosage & Administration”.

Ask a doctor first if

  • liver disease stomach bleeding warning applies to you
  • you have problems or serious side effects from taking pain relievers
  • you have a history of stomach problems, such as heartburn
  • you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke
  • you are taking a diuretic

Quoted from the official label, section “OTC — Ask Doctor”.

Ask a pharmacist first if

you are under a doctor's care for any serious condition taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin taking any other drug

Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.

Stop and get help if

  • you experience any of the following signs of stomach bleeding:
  • feel faint vomit blood have bloody or black stools have stomach pain that does not get better
  • you have symptoms of heart problems or stroke:
  • chest pain trouble breathing weakness in one part or side of body slurred speech leg swelling pain gets worse or lasts more than 10 days redness or swelling is present in the painful area any new symptoms appear

Quoted from the official label, section “OTC — Stop Use”.

Other warnings

  • Acetaminophen liver damage warning: This product contains acetaminophen.
  • Severe liver damage may occur
  • if you take:
  • with other drugs containing acetaminophen more than 6 caplets in 24 hours, which is the maximum daily amount for this product 3 or more alcoholic drinks every day while using this product.
  • Acetaminophen allergy alert: may cause severe skin reactions.
  • Symptoms may include:
  • skin reddening blisters rash If skin reaction occurs,
  • stop use and seek medical help right away.
  • NSAID allergy alert:
  • ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin.
  • Symptoms may include:
  • hives facial swelling asthma (wheezing) shock skin reddening rash blisters If an allergic reaction occurs,
  • stop use and seek medical help right away.
  • NSAID stomach bleeding warning:
  • This product contains an NSAID, which may cause severe stomach bleeding.
  • The chance is higher
  • if you:
  • are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Heart attack and stroke warning:
  • NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke.
  • These can be fatal.
  • The risk is higher if you use more than directed or for longer than directed.
  • Do not use with any other drug containing acetaminophen (prescription or nonprescription).
  • Ask a doctor before use
  • if you have liver disease stomach bleeding warning applies to you
  • Ask a doctor or pharmacist before use
  • if you are under a doctor's care for any serious condition taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin taking any other drug
  • When using this product take with food or milk if stomach upset occurs
  • Stop use and
  • ask a doctor
  • if you experience any of the following signs of stomach bleeding:
  • chest pain trouble breathing weakness in one part or side of body slurred speech leg swelling pain gets worse or lasts more than 10 days redness or swelling is present in the painful area any new symptoms appear If pregnant or breast-feeding, ask a health professional before use.
  • Keep out of reach of children.
  • take with food or milk if stomach upset occurs

Quoted from the official label, section “Warnings”.

Pregnancy and breastfeeding

  • If pregnant or breast-feeding, ask a health professional before use.
  • It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.

Keep away from children

  • In case of overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for
  • adults as well as for children even
  • if you do not notice any signs or symptoms.

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

How to store it

  • each caplet contains:
  • sodium 3 mg read all warnings and directions before use. Keep carton.
  • store at 20°C to 25°C (68°F to 77°F)
  • avoid excessive heat above 40°C (104°F)

Quoted from the official label, section “Storage and Handling”.

What kind of medicine it is

Pain reliever Pain reliever

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

carnauba wax, colloidal silicon dioxide, croscarmellose sodium, crospovidone, ferric oxide red, ferric oxide yellow, glyceryl dibehenate, hypromellose, microcrystalline cellulose, polydextrose, polyethylene glycol, povidone, pregelatinized starch, sodium lauryl sulphate, stearic acid, titanium dioxide

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

call toll-free 1-888-235-2466

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

  • Titanium dioxidetitanium dioxideA whitening agent no longer allowed in food in the EU (E171).

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (19)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

Hide versions whose label lists:

Showing 19 of 19

Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

Medicine passport: one printable page to show a pharmacist abroad

NetherlandsNo exact match for this strength and form

Details

Made byAMERISOURCE BERGEN
Active substanceAcetaminophen and Ibuprofen
Used inMuscles, joints and bones
Strength125 mg + 250 mg
FormTablet, Film Coated
RouteOral
Packs36 TABLET, FILM COATED in 1 CARTON · 1 BOTTLE in 1 CARTON / 80 TABLET, FILM COATED in 1 BOTTLE
NDC46122-742
NDC46122-818

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

Other strengths and forms

18 products are sold under this name. Grouped by form; a number on a strength means several companies make it.

Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.