Medicine guide

Careone Naproxen Sodium Pm

25 mg + 220 mg · Tablet, Film Coated

Available without prescription
Histamine-1 Receptor Antagonist

Active substance: Diphenhydramine Hydrochloride, Naproxen Sodium
Used in: Muscles, joints and bones
Made by: American Sales Company
Source: Official label

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2023-12-11

What it is

Nighttime sleep-aid Pain reliever

Used for

For relief of occasional sleeplessness when associated with minor aches and pains
Helps you fall asleep and stay asleep

How to take it

Adults and children 12 years and over: take 2 caplets at bedtime

do not take more than 2 caplets in 24 hours

Full directions ↓

Do not take it if

If you have ever had an allergic reaction to any other pain reliever/fever reducer

All warnings ↓

Good to know

Sold without a prescription
FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02

11other products contain Diphenhydramine Hydrochloride, Naproxen Sodium — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

for relief of occasional sleeplessness when associated with minor aches and pains
helps you fall asleep and stay asleep

From the official label · 2023-12-11 · DailyMed

Do not take it if

if you have ever had an allergic reaction to any other pain reliever/fever reducer
unless you have time for a full night’s sleep
in children under 12 years of age
right before or after heart surgery
with any other product containing diphenhydramine, even one used on skin
if you have sleeplessness without pain

Quoted from the official label, section “OTC — Do Not Use”.

How to take it

These directions are for this exact strength and form. Another one is different.

do not take more than directed
drink a full glass of water with each dose
adults and children 12 years and over: take 2 caplets at bedtime
do not take more than 2 caplets in 24 hours
if taken with food, this product may take longer to work

Quoted from the official label, section “Dosage & Administration”.

Ask a doctor first if

stomach bleeding warning applies to you
you have problems or serious side effects from taking pain relievers or fever reducers
you have a history of stomach problems, such as heartburn
you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke
you are taking a diuretic
you have a breathing problem such as emphysema or chronic bronchitis
you have glaucoma
you have trouble urinating due to an enlarged prostate gland

Quoted from the official label, section “OTC — Ask Doctor”.

Ask a pharmacist first if

you are
taking sedatives or tranquilizers, or any other sleep-aid
under a doctor’s care for any serious condition
taking aspirin for heart attack or stroke, because naproxen may decrease this benefit of aspirin
taking any other antihistamines
taking any other drug

Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.

Stop and get help if

you experience any of the following signs of stomach bleeding:
feel faint
vomit blood
have bloody or black stools
have stomach pain that does not get better
you have symptoms of heart problems or stroke:
chest pain
trouble breathing
weakness in one part or side of body
slurred speech
leg swelling
pain gets worse or lasts more than 10 days
sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of a serious underlying medical illness.
redness or swelling is present in the painful area
any new symptoms appear
you have difficulty swallowing
it feels like the pill is stuck in your throat

Quoted from the official label, section “OTC — Stop Use”.

Other warnings

Allergy alert:
Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
hives
facial swelling
asthma (wheezing)
shock
skin reddening
rash
blisters If an allergic reaction occurs,
stop use and seek medical help right away. Stomach bleeding warning:
This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher
if you:
are age 60 or older
have had stomach ulcers or bleeding problems
take a blood thinning (anticoagulant) or steroid drug
take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
have 3 or more alcoholic drinks every day while using this product
take more or for a longer time than directed Heart attack and stroke warning:
NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher
if you use more than directed or for longer than directed.
Do not use
if you have sleeplessness without pain Ask a doctor before use if
Ask a doctor or pharmacist before use
if you are
taking any other drug When using this product
drowsiness will occur
avoid alcoholic drinks
do not drive a motor vehicle or operate machinery
take with food or milk if stomach upset occurs Stop use and ask a doctor if
feel faint
vomit blood
chest pain
leg swelling
it feels like the pill is stuck in your throat If pregnant or breast feeding, ask a health professional before use. It is especially important not to use naproxen sodium at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).
drowsiness will occur
avoid alcoholic drinks
do not drive a motor vehicle or operate machinery
take with food or milk if stomach upset occurs

Quoted from the official label, section “Warnings”.

Pregnancy and breastfeeding

If pregnant or breast feeding, ask a health professional before use.
It is especially important not to use naproxen sodium at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.

Keep away from children

In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

Other information

read all warnings and directions before use . Keep outer carton .
each caplet contains: sodium 21 mg
store at 20-25°C (68-77°F)
avoid high humidity and excessive heat above 40°C (104°F)

Quoted from the official label, section “OTC — Other Information”.

What kind of medicine it is

Nighttime sleep-aid Pain reliever

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

croscarmellose sodium, FD&C blue #1 aluminum lake, FD&C blue #2 aluminum lake, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, silicon dioxide, talc, titanium dioxide

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

1-800-719-9260

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

Colour dyesFD&C blue #1 aluminum lake; FD&C blue #2 aluminum lakeSome people react to dyes such as tartrazine (Yellow 5) or carmine.
Titanium dioxidetitanium dioxideA whitening agent no longer allowed in food in the EU (E171).

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (14)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

Showing 14 of 14

Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

Medicine passport: one printable page to show a pharmacist abroad

CanadaNo exact match for this strength and form

Every strength and form (2)

Details

Made by	American Sales Company
Active substance	Diphenhydramine Hydrochloride, Naproxen Sodium
Used in	Muscles, joints and bones
Strength	25 mg + 220 mg
Form	Tablet, Film Coated
Route	Oral
Packs	1 BOTTLE in 1 CARTON / 80 TABLET, FILM COATED in 1 BOTTLE · 1 BOTTLE in 1 CARTON / 20 TABLET, FILM COATED in 1 BOTTLE
NDC	41520-264

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

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Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

All Night Pain Relief Pm25 mg + 220 mgWithout prescriptionTablet, Film Coated Walgreen Company · Diphenhydramine Hydrochloride, Naproxen Sodium Basic Care Naproxen Sodium Pm25 mg + 220 mgWithout prescriptionTablet, Film Coated Amazon.com Services LLC · Diphenhydramine Hydrochloride, Naproxen Sodium Dg Health Naproxen Sodium Pm25 mg + 220 mgWithout prescriptionTablet, Film Coated Dolgencorp Inc · Diphenhydramine Hydrochloride, Naproxen Sodium Equaline Naproxen Sodium Pm25 mg + 220 mgWithout prescriptionTablet, Film Coated United Natural Foods, Inc. dba UNFI · Diphenhydramine Hydrochloride, Naproxen Sodium Good Sense Naproxen Sodium25 mg + 220 mgWithout prescriptionTablet, Film Coated L. Perrigo Company · Diphenhydramine Hydrochloride, Naproxen Sodium Naproxen Sodium Pm25 mg + 220 mgWithout prescriptionTablet, Film Coated Safeway · Diphenhydramine Hydrochloride, Naproxen Sodium

See every product with Diphenhydramine Hydrochloride, Naproxen Sodium