Mediclarum
Medicine guide

Excedrin Migraine Relief

250 mg + 250 mg + 65 mg · Tablet, Film Coated

  • Available without prescription
  • Central Nervous System Stimulant
Made by
Haleon US Holdings LLC

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2025-03-11

What it is

Pain reliever Pain reliever Pain reliever aid

Used for
  • Treats migraine
How to take it

Adults: take 2 caplets with a glass of water

Full directions ↓
Do not take it if

If you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer

All warnings ↓
Good to know
  • Sold without a prescription
  • FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
3other products contain Acetaminophen, Aspirin (nsaid), Caffeine — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

  • treats migraine

From the official label · 2025-03-11 · DailyMed

Do not take it if

  • if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
  • with any other drug containing acetaminophen (prescription or nonprescription).
  • If you are not sure whether a drug contains acetaminophen,
  • ask a doctor or pharmacist.

Quoted from the official label, section “OTC — Do Not Use”.

How to take it

These directions are for this exact strength and form. Another one is different.

  • do not use more than directed
  • adults: take 2 caplets with a glass of water
  • if symptoms persist or worsen, ask your doctor
  • do not take more than
  • 2 caplets in 24 hours, unless directed by a doctor
  • under 18 years of age: ask a doctor

Quoted from the official label, section “Dosage & Administration”.

Ask a doctor first if

  • Ask doctor before use if
  • you have never had migraines diagnosed by a health professional
  • you have a headache that is different from your usual migraines
  • you have the worst headache of your life
  • you have fever and stiff neck
  • you have headaches beginning after or caused by head injury, exertion, coughing or bending
  • you experienced your first headache after the age of 50
  • you have daily headaches
  • you have a migraine so severe as to require bed rest
  • you have liver disease
  • stomach bleeding warning applies to you
  • you have a history of stomach problems, such as heartburn
  • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
  • you are taking a diuretic
  • you have asthma
  • you have problems or serious side effects from taking pain relievers or fever reducers
  • you have vomiting with your migraine headache

Quoted from the official label, section “OTC — Ask Doctor”.

Ask a pharmacist first if

  • you are
  • taking a prescription drug for:
  • diabetes
  • gout
  • arthritis
  • under a doctor’s care for any serious condition
  • taking any other drug
  • taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer

Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.

Stop and get help if

  • an allergic reaction occurs. Seek medical help right away.
  • you experience any of the following signs of stomach bleeding:
  • feel faint
  • vomit blood
  • have bloody or black stools
  • have stomach pain that does not get better
  • your migraine is not relieved or worsens after first dose
  • new or unexpected symptoms occur
  • ringing in the ears or loss of hearing occurs

Quoted from the official label, section “OTC — Stop Use”.

Other warnings

  • Reye’s syndrome:
  • Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
  • When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert:
  • Acetaminophen may cause severe skin reactions. Symptoms may include:
  • skin reddening
  • blisters
  • rash If a skin reaction occurs,
  • stop use and seek medical help right away. Allergy alert:
  • Aspirin may cause a severe allergic reaction which may include:
  • hives
  • facial swelling
  • asthma (wheezing)
  • shock Liver warning:
  • This product contains acetaminophen. Severe liver damage may occur
  • if you take
  • more than 2 caplets in 24 hours, which is the maximum daily amount
  • with other drugs containing acetaminophen
  • 3 or more alcoholic drinks every day while using this product Stomach bleeding warning:
  • This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher
  • if you
  • are age 60 or older
  • have had stomach ulcers or bleeding problems
  • take a blood thinning (anticoagulant) or steroid drug
  • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
  • have 3 or more alcoholic drinks every day while using this product
  • take more or for a longer time than directed Medication overuse headache warning:
  • Headaches may worsen if this product is used for 10 or more days per month. Caffeine warning:
  • The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.
  • Do not use
  • ask a doctor or pharmacist. Ask doctor before use if
  • Ask a doctor or pharmacist before use
  • if you are
  • diabetes
  • gout
  • arthritis
  • Stop use and
  • ask a doctor if
  • feel faint
  • vomit blood
  • ringing in the ears or loss of hearing occurs If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for

Quoted from the official label, section “Warnings”.

Pregnancy and breastfeeding

  • If pregnant or breast-feeding, ask a health professional before use.
  • It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery

Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.

Keep away from children

  • In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for
  • adults as well as for children even
  • if you do not notice any signs or symptoms.

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

What kind of medicine it is

Pain reliever Pain reliever Pain reliever aid

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

benzoic acid, carnauba wax, FD&C blue no. 1, hypromellose, light mineral oil, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, polysorbate 20, povidone, propylene glycol, simethicone, sorbitan monolaurate, stearic acid, titanium dioxide

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

1-800-468-7746

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

  • Colour dyesFD&C blue no. 1Some people react to dyes such as tartrazine (Yellow 5) or carmine.
  • Titanium dioxidetitanium dioxideA whitening agent no longer allowed in food in the EU (E171).

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (6)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

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Showing 6 of 6

Details

Made byHaleon US Holdings LLC
Active substanceAcetaminophen, Aspirin (nsaid), Caffeine
Used inMuscles, joints and bones
Strength250 mg + 250 mg + 65 mg
FormTablet, Film Coated
RouteOral
Packs1 BOTTLE in 1 CARTON / 24 TABLET, FILM COATED in 1 BOTTLE · 1 BOTTLE in 1 CARTON / 30 TABLET, FILM COATED in 1 BOTTLE
NDC0067-2042

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

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Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

Excedrin Extra Strength Headache250 mg + 250 mg + 65 mgWithout prescriptionTablet, Film Coated Haleon US Holdings LLC · Acetaminophen, Aspirin (nsaid), CaffeineExcedrin Extra Strength Headache250 mg + 250 mg + 65 mgWithout prescriptionTablet, Film Coated R J General Corporation · Acetaminophen, Aspirin (nsaid), CaffeineExcedrin Extra Strength Headache250 mg + 250 mg + 65 mgWithout prescriptionTablet, Film Coated Select Consumer Group · Acetaminophen, Aspirin (nsaid), Caffeine

See every product with Acetaminophen, Aspirin (nsaid), Caffeine