Mediclarum
Medicine guide

Metformin Hydrochloride

750 mg · Tablet, Extended Release

  • Prescription only
  • Biguanide
Active substance
Metformin Hydrochloride
Made by
AvPAK

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

What it is for

Medicine groupDigestion, stomach, diabetes and nutrition

Mediclarum has not yet retrieved and stored the official label for this product, so none of its text is shown here. Open the official leaflet

How it works

From the US prescribing label for the same active substance (Metformin Hydrochloride). It describes the substance, not this exact product.

Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering both basal and postprandial plasma glucose.

Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Half-life6.2 h
Mostly cleared after≈ 31 hfive half-lives — our arithmetic
How it leaves the body

Intravenous single-dose studies in normal subjects demonstrate that metformin is excreted unchanged in the urine and does not undergo hepatic metabolism (no metabolites have been identified in humans) nor biliary excretion.

Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-01-01

Safety of the active substance

From the US prescribing label for the same active substance (Metformin Hydrochloride). It describes the substance, not this exact product.

Serious warning

WARNING: LACTIC ACIDOSIS Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias.

Must not be used by
  • Metformin hydrochloride tablets are contraindicated in patients with: Severe renal impairment (eGFR below 30 mL/min/1.73 m 2 ) [see Warnings and Precautions (5.1) ].
  • Hypersensitivity to metformin.
  • Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
  • Severe renal impairment (eGFR below 30 mL/min/1.73 m 2 ) ( 4, 5.1 ) Hypersensitivity to metformin ( 4 ) Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.

Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed

Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

Medicine passport: one printable page to show a pharmacist abroad

Bulgaria10 matching products

Every strength and form (62)

CanadaNo exact match for this strength and form

Every strength and form (80)

Details

Made byAvPAK
Active substanceMetformin Hydrochloride
Used inDigestion, stomach, diabetes and nutrition
Strength750 mg
FormTablet, Extended Release
RouteOral
Packs50 BLISTER PACK in 1 BOX / 1 TABLET, EXTENDED RELEASE in 1 BLISTER PACK
NDC50268-551

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

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Other strengths and forms

250 products are sold under this name. Grouped by form; a number on a strength means several companies make it.

Show all forms · 6 forms

Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

Glumetza500 mgPrescription onlyTablet, Film Coated, Extended Release Santarus, Inc. · Metformin HydrochlorideGlumetza1000 mgPrescription onlyTablet, Film Coated, Extended Release Santarus, Inc. · Metformin HydrochlorideMetformin Hydrochloride500 mgPrescription onlyTablet, Film Coated Mylan Pharmaceuticals Inc. · Metformin HydrochlorideMetformin Hydrochloride850 mgPrescription onlyTablet, Film Coated Mylan Pharmaceuticals Inc. · Metformin HydrochlorideMetformin Hydrochloride1000 mgPrescription onlyTablet, Film Coated Mylan Pharmaceuticals Inc. · Metformin HydrochlorideMetformin Hydrochloride500 mgPrescription onlyTablet, Film Coated NCS HealthCare of KY, LLC dba Vangard Labs · Metformin Hydrochloride

See every product with Metformin Hydrochloride