Glucophage XR
On the Bulgarian pack: Глюкофаж XP 750 mg таблетки с удължено освобождаване
750 mg · prolonged - release tablets
- Prescription only
- Digestion, stomach, diabetes and nutrition
- Active substance
- Metformin
- Made by
- Merk Balgaria EAD
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet read the official leaflet for this product. The exact uses and dose are in the leaflet inside the pack. Open the official leaflet
How it works
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (metformin hydrochloride). It describes the substance, not this Bulgarian product — its uses and doses can differ.
Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering both basal and postprandial plasma glucose.
Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Intravenous single-dose studies in normal subjects demonstrate that metformin is excreted unchanged in the urine and does not undergo hepatic metabolism (no metabolites have been identified in humans) nor biliary excretion.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-01-01
Safety of the active substance
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (metformin hydrochloride). It describes the substance, not this Bulgarian product — its uses and doses can differ.
WARNING: LACTIC ACIDOSIS Postmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias.
- Metformin hydrochloride tablets are contraindicated in patients with: Severe renal impairment (eGFR below 30 mL/min/1.73 m 2 ) [see Warnings and Precautions (5.1) ].
- Hypersensitivity to metformin.
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
- Severe renal impairment (eGFR below 30 mL/min/1.73 m 2 ) ( 4, 5.1 ) Hypersensitivity to metformin ( 4 ) Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United States36 matching products
SpainNo exact match for this strength and form
CanadaNo exact match for this strength and form
Netherlands3 matching products
SwitzerlandNo exact match for this strength and form
Details
| Made by | Merk Balgaria EAD · Bulgaria |
|---|---|
| Active substance | Metformin |
| Used in | Digestion, stomach, diabetes and nutrition |
| Strength | 750 mg |
| Form | prolonged - release tablets |
| Pack sizes | 30 · 60 |
| Classification | A10BA02 · Digestion, stomach, diabetes and nutrition |
| Name in the register | Глюкофаж XP 750 mg таблетки с удължено освобождаване |
| Reg. no. | 20180182 |
Source: Bulgarian Drug Agency register · 2026-08-01 · not reviewed by a clinician
Източник: Изпълнителна агенция по лекарствата (ИАЛ). The publisher’s terms do not grant reproduction, so text is shortened and linked. Publisher’s terms.
Other strengths and forms
2 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- prolonged - release tablets2 products
- 500 mg
- 750 mg
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.