Mediclarum
Medicine guide

Naproxen Sodium

220 mg · Capsule, Liquid Filled

  • Available without prescription
  • Nonsteroidal Anti-inflammatory Drug
Active substance
Naproxen Sodium
Made by
Care One (American Sales Company)

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2022-11-21

What it is

Pain reliever/fever reducer

Used for
  • Minor pain of arthritis muscular aches backache menstrual cramps headache toothache the common cold temporarily reduces fever
How to take it

Adults and children 12 years and older:: take 1 capsule every 8 to 12 hours while symptoms last for the first dose you may

Full directions ↓
Do not take it if

If you have ever had an allergic reaction to any other pain reliever/fever reducer right before or after heart surgery

All warnings ↓
Good to know
  • Sold without a prescription
  • FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
214other products contain Naproxen Sodium — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

temporarily relieves minor aches and pains due to:

  • minor pain of arthritis muscular aches backache menstrual cramps headache toothache the common cold temporarily reduces fever

From the official label · 2022-11-21 · DailyMed

How it works

From the US prescribing label for the same active substance (Naproxen). It describes the substance, not this exact product.

Naproxen has analgesic, anti-inflammatory, and antipyretic properties.

The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Peak level after2–4 h
Half-life12–17 h
Mostly cleared after≈ 3 daysfive half-lives — our arithmetic
PeakHalf gone3 days0
The shape is a standard model drawn from the two times above, not a measurement. How fast a medicine acts and wears off also depends on the dose, the form and the person.
How the body breaks it down

Naproxen is extensively metabolized in the liver to 6-0-desmethyl naproxen, and both parent and metabolites do not induce metabolizing enzymes.

How it leaves the body

Approximately 95% of the naproxen from any dose is excreted in the urine, primarily as naproxen (<1%), 6-0-desmethyl naproxen (<1%) or their conjugates (66% to 92%).

Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-18

Do not take it if

if you have ever had an allergic reaction to any other pain reliever/fever reducer right before or after heart surgery

Quoted from the official label, section “OTC — Do Not Use”.

How to take it

These directions are for this exact strength and form. Another one is different.

  • do not take more than directed
  • the smallest effective dose should be used drink a full glass of water with each dose if taken with food, this product may take longer to work
  • adults and children 12 years and older:
  • take 1 capsule every 8 to 12 hours while symptoms last for the first dose you may
  • take 2 capsules within the first hour
  • do not exceed 2 capsules in any 8- to 12-hour period
  • do not exceed 3 capsules in a 24-hour period
  • children under 12 years:
  • ask a doctor

Quoted from the official label, section “Dosage & Administration”.

Ask a doctor first if

  • the stomach bleeding warning applies to you
  • you have a history of stomach problems, such as heartburn
  • you have high blood pressure, heart disease, liver cirrhosis, kidney disease,asthma, or had a stroke
  • you are taking a diuretic
  • you have problems or serious side effects from taking pain relievers or fever reducers

Quoted from the official label, section “OTC — Ask Doctor”.

Ask a pharmacist first if

you are under a doctor’s care for any serious condition taking any other drug

Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.

Stop and get help if

  • you experience any of the following signs of stomach bleeding:
  • feel faint have bloody or black stools vomit blood have stomach pain that does not get better
  • you have symptoms of heart problems or stroke:
  • chest pain slurred speech leg swelling trouble breathing weakness in one part or side of body pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present in the painful area any new symptoms appear
  • you have difficulty swallowing it feels like the capsule is stuck in your throat

Quoted from the official label, section “OTC — Stop Use”.

Other warnings

  • Allergy alert:
  • Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin.
  • Symptoms may include:
  • hives facial swelling asthma (wheezing) shock skin reddening rash blisters If an allergic reaction occurs,
  • stop use and seek medical help right away.
  • Stomach bleeding warning:
  • This product contains an NSAID, which may cause severe stomach bleeding.
  • The chance is higher
  • if you:
  • are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug have 3 or more alcoholic drinks every day while using this product take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) take more or for a longer time than directed Heart attack and stroke:
  • NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke.
  • These can be fatal.
  • The risk is higher if you use more than directed or for longer than directed.
  • Do not use
  • Ask a doctor before use if the stomach bleeding warning applies to you
  • Ask a doctor or pharmacist before use
  • if you are under a doctor’s care for any serious condition taking any other drug
  • When using this product take with food or milk if stomach upset occurs
  • Stop use and
  • ask a doctor
  • if you experience any of the following signs of stomach bleeding:
  • you have difficulty swallowing it feels like the capsule is stuck in your throat If pregnant or breast-feeding, ask a health professional before use.
  • Keep out of reach of children.
  • take with food or milk if stomach upset occurs

Quoted from the official label, section “Warnings”.

Pregnancy and breastfeeding

  • If pregnant or breast-feeding, ask a health professional before use.
  • It is especially important not to use naproxen sodium during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.

Keep away from children

In case of overdose, get medical help or contact a Poison Control Center right away.(1-800-222-1222).

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

How to store it

  • each capsule contains:
  • sodium 20 mg
  • store at 20-25°C (68-77°F).
  • Avoid high humidity and excessive heat above 40°C (104°F). read all directions and warnings before use. Keep carton. swallow whole; do not crush, chew, or dissolve

Quoted from the official label, section “Storage and Handling”.

What kind of medicine it is

Pain reliever/fever reducer

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

FD&C blue #1, gelatin, glycerin, lactic acid, lecithin, light mineral oil, n-butyl alcohol, polyethylene glycol, povidone, propylene glycol, purified water, shellac glaze, sorbitan, sorbitol solution, titanium dioxide, white ink

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

Call 1-877-753-3935 Monday-Friday 9AM-5PM EST

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

  • Colour dyesFD&C blue #1Some people react to dyes such as tartrazine (Yellow 5) or carmine.
  • Sugar alcoholssorbitol solutionSorbitol and similar can upset the stomach and matter with fructose intolerance.
  • Alcohol (ethanol)n-butyl alcoholMatters for children, in pregnancy, in recovery and with some medicines.
  • GelatingelatinAnimal-derived: matters for vegetarian, vegan, halal and kosher diets.
  • SoylecithinMatters with a soy allergy.
  • Titanium dioxidetitanium dioxideA whitening agent no longer allowed in food in the EU (E171).

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (35)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

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Showing 35 of 35

Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

Medicine passport: one printable page to show a pharmacist abroad

Canada5 matching products

Every strength and form (45)

NetherlandsNo exact match for this strength and form

Every strength and form (24)

Details

Made byCare One (American Sales Company)
Active substanceNaproxen Sodium
Used inMuscles, joints and bones
Strength220 mg
FormCapsule, Liquid Filled
RouteOral
Packs1 BOTTLE, PLASTIC in 1 BOX / 20 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC · 1 BOTTLE, PLASTIC in 1 BOX / 80 CAPSULE, LIQUID FILLED in 1 BOTTLE, PLASTIC
NDC41520-748

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

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Other strengths and forms

107 products are sold under this name. Grouped by form; a number on a strength means several companies make it.

Show all forms · 6 forms

Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

Aleve220 mgWithout prescriptionTablet Bayer HealthCare LLC. · Naproxen SodiumAleve220 mgWithout prescriptionCapsule, Liquid Filled Bayer HealthCare LLC. · Naproxen SodiumAleve220 mgWithout prescriptionTablet Navajo Manufacturing Company Inc. · Naproxen SodiumAleve220 mgWithout prescriptionTablet Navajo Manufacturing Company Inc · Naproxen SodiumAleve220 mgWithout prescriptionTablet R J General Corporation · Naproxen SodiumAleve Back and Muscle Pain220 mgWithout prescriptionTablet Bayer HealthCare LLC. · Naproxen Sodium

See every product with Naproxen Sodium