Silver Sulfadiazine

Do not take it if

Quoted from the official label, section “Contraindications”.

How to take it

These directions are for this exact strength and form. Another one is different.

• FOR TOPICAL USE ONLY - NOT FOR OPHTHALMIC USE:
• Prompt institution of appropriate regimens for care of the burned patient is of prime importance and includes the control of shock and pain.
• The burn wounds are then cleansed and debrided;
• Silver Sulfadiazine Cream is then applied under sterile conditions.
• The burn areas should be covered with Silver Sulfadiazine Cream at all times.
• The cream should be applied once to twice daily to a thickness of approximately one sixteenth of an inch.
• Whenever necessary, the cream should be reapplied to any areas from which it has been removed due to patient activity.
• Administration may be accomplished in minimal time because dressings are not required.
• However, if individual patient requirements make dressings necessary, they may be used.
• Reapply immediately after hydrotherapy.
• Treatment with Silver Sulfadiazine Cream should be continued until satisfactory healing has occurred or until the burn site is ready for grafting.
• The drug should not be withdrawn from the therapeutic regimen while there remains the possibility of infection except if a significant adverse reaction occurs.

Quoted from the official label, section “Dosage & Administration”.

Other warnings

Quoted from the official label, section “Warnings”.

Side effects

• Several cases of transient leucopenia have been reported in patients receiving silver sulfadiazine therapy.
• Leucopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count.
• Maximal white blood cell depression occurs within two to four days of initiation of therapy.
• Rebound to normal leukocyte levels follows onset within two to three days.
• Recovery is not influenced by continuation of silver sulfadiazine therapy.
• The incidence of leucopenia in various reports averages about 20%.
• A higher incidence has been seen in patients treated concurrently with cimetidine.
• Other infrequently occurring events include skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes, and interstitial nephritis.
• Reduction in bacterial growth after application of topical antibacterial agents has been reported to permit spontaneous healing of deep partial thickness burns by preventing conversion of the partial thickness to full thickness by sepsis.
• However, reduction in bacterial colonization has caused delayed separation, in some cases necessitating escharotomy in order to prevent contracture.
• Absorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage.
• Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur.
• Some of the reactions which have been associated with sulfonamides are as follows:
• blood dyscrasias, agranulocytosis, aplastic anemia, thrombocytopenia, leucopenia, hemolytic anemia, dermatologic reactions, allergic reactions, Stevens-Johnson syndrome, exfoliative dermatitis, gastrointestinal reactions, hepatitis, hepatocellular necrosis, CNS reactions, and toxic nephrosis.

Quoted from the official label, section “Adverse Reactions”.

What it looks like and how it is packed

• 1% Silver Sulfadiazine Cream :
• white to off-white cream. 25 gram tube NDC 76420-208-25 (relabeled from NDC 43598-210-25) 50 gram tube NDC 76420-208-50 (relabeled from NDC 43598-210-50)
• Store at controlled room temperature 15° - 30°C (59° - 86°F) SSD is a trademark of Dr.
• Reddy's Laboratories, Inc.
• Relabeled by: Enovachem PHARMACEUTICALS Torrance, CA 90501

Quoted from the official label, section “How Supplied”.

What is in it

• DESCRPITION 1% Silver Sulfadiazine Cream are topical antibacterial preparations which have as their active antimicrobial ingredient silver sulfadiazine.
• The active moiety is contained within an opaque, white, water miscible cream base.
• Each 1000 grams of 1% Silver Sulfadiazine Cream contains 10 grams of silver sulfadiazine.
• Inactive Ingrediants:
• cetyl alcohol, isopropyl myristate, polyoxyl 40 stearate, propylene glycol, purified water, stearyl alcohol, sodium hydroxide, sorbitan monooleate, white petrolatum; with 0.3% methyl paraben, as a preservative.
• Silver sulfadiazine has an emprical formula of C 10 H 9 AgN 4 O 2 S, molecular weight of 357.14 and structural formula as shown:
• Structure for silver sulfadiazine

Quoted from the official label, section “Description”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

Details

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

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Other strengths and forms

9 products are sold under this name. Grouped by form; a number on a strength means several companies make it.

Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

See every product with Silver Sulfadiazine