Medicine guide

Ssd Cream

10 g/1000g · Cream

  • Prescription only
  • Sulfonamide Antibacterial
Active substance
Silver Sulfadiazine
Made by
St. Mary's Medical Park Pharmacy

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2026-06-10

What it is

Sulfonamide Antibacterial

Used for
  • Silver Sulfadiazine Cream is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second and third degree burns.
Do not take it if

Silver Sulfadiazine Cream is contraindicated in patients who are hypersensitive to silver sulfadiazine or any of the other ingredients in the preparation.

All warnings ↓
Good to know
  • Prescription only
  • FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
16other products contain Silver Sulfadiazine — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

  • Silver Sulfadiazine Cream is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second and third degree burns.

From the official label · 2026-06-10 · DailyMed

How it works

From this product’s own US prescribing label.

Silver sulfadiazine has broad antimicrobial activity.

It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast.

Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-06-10

Do not take it if

  • Silver Sulfadiazine Cream is contraindicated in patients who are hypersensitive to silver sulfadiazine or any of the other ingredients in the preparation.
  • Because sulfonamide therapy is known to increase the possibility of kernicterus, Silver Sulfadiazine Cream should not be used on pregnant women approaching or at term, on premature infants, or on newborn infants during the first 2 months of life.

Quoted from the official label, section “Contraindications”.

How to take it

These directions are for this exact strength and form. Another one is different.

  • FOR TOPICAL USE ONLY - NOT FOR OPHTHALMIC USE:
  • Prompt institution of appropriate regimens for care of the burned patient is of prime importance and includes the control of shock and pain.
  • The burn wounds are then cleansed and debrided;
  • Silver Sulfadiazine Cream is then applied under sterile conditions.
  • The burn areas should be covered with Silver Sulfadiazine Cream at all times.
  • The cream should be applied once to twice daily to a thickness of approximately one sixteenth of an inch.
  • Whenever necessary, the cream should be reapplied to any areas from which it has been removed due to patient activity.
  • Administration may be accomplished in minimal time because dressings are not required.
  • However, if individual patient requirements make dressings necessary, they may be used.
  • Reapply immediately after hydrotherapy.
  • Treatment with Silver Sulfadiazine Cream should be continued until satisfactory healing has occurred or until the burn site is ready for grafting.
  • The drug should not be withdrawn from the therapeutic regimen while there remains the possibility of infection except if a significant adverse reaction occurs.

Quoted from the official label, section “Dosage & Administration”.

Other warnings

  • There is a potential cross-sensitivity between silver sulfadiazine and other sulfonamides.
  • If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.
  • Fungal proliferation in and below the eschar may occur.
  • However, the incidence of clinically reported fungal superinfection is low.
  • The use of Silver Sulfadiazine Cream in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur.
  • PRECAUTION If hepatic and renal functions become impaired and elimination of the drug decreases accumulation may occur and discontinuation of Silver Sulfadiazine Cream should be weighed against the therapeutic benefit being achieved.
  • In considering the use of topical proteolytic enzymes in conjunction with Silver Sulfadiazine Cream, the possibility should be noted that silver may inactivate such enzymes.
  • Laboratory Tests:
  • In the treatment of burn wounds involving extensive areas of the body, the serum sulfa concentrations may approach adult therapeutic levels (8 to 12mg %).
  • Therefore, in these patients it would be advisable to monitor serum sulfa concentrations.
  • Renal function should be carefully monitored and the urine should be checked for sulfa crystals.
  • Absorption of the propylene glycol vehicle has been reported to affect serum osmolality, which may affect the interpretation of laboratory tests.

Quoted from the official label, section “Warnings”.

Side effects

  • Several cases of transient leucopenia have been reported in patients receiving silver sulfadiazine therapy.
  • Leucopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count.
  • Maximal white blood cell depression occurs within two to four days of initiation of therapy.
  • Rebound to normal leukocyte levels follows onset within two to three days.
  • Recovery is not influenced by continuation of silver sulfadiazine therapy.
  • The incidence of leucopenia in various reports averages about 20%.
  • A higher incidence has been seen in patients treated concurrently with cimetidine.
  • Other infrequently occurring events include skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes, and interstitial nephritis.
  • Reduction in bacterial growth after application of topical antibacterial agents has been reported to permit spontaneous healing of deep partial thickness burns by preventing conversion of the partial thickness to full thickness by sepsis.
  • However, reduction in bacterial colonization has caused delayed separation, in some cases necessitating escharotomy in order to prevent contracture.
  • Absorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage.
  • Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur.
  • Some of the reactions which have been associated with sulfonamides are as follows:
  • blood dyscrasias, agranulocytosis, aplastic anemia, thrombocytopenia, leucopenia, hemolytic anemia, dermatologic reactions, allergic reactions, Stevens-Johnson syndrome, exfoliative dermatitis, gastrointestinal reactions, hepatitis, hepatocellular necrosis, CNS reactions, and toxic nephrosis.

Quoted from the official label, section “Adverse Reactions”.

What it looks like and how it is packed

  • SSD™ (1% Silver Sulfadiazine) Cream :
  • white to off-white cream. 50 gram tube NDC 60760-962-50
  • Store at controlled room temperature 15° - 30°C (59° - 86°F) SSD is a trademark of Dr. Reddy's Laboratories, Inc.

Quoted from the official label, section “How Supplied”.

What is in it

  • DESCRPITION SSD™ (1% Silver Sulfadiazine Cream) and SSD AF™ (1% Silver Sulfadiazine Cream), 1% are topical antibacterial preparations which have as their active antimicrobial ingredient silver sulfadiazine.
  • The active moiety is contained within an opaque, white, water miscible cream base.
  • Each 1000 grams of SSD/SSD AF Cream contains 10 grams of silver sulfadiazine.
  • Inactive Ingrediants:
  • cetyl alcohol (SSD Cream only), isopropyl myristate, polyoxyl 40 stearate, propylene glycol, purified water, stearyl alcohol, sodium hydroxide, sorbitan monooleate, white petrolatum; with 0.3% methyl paraben, as a preservative.
  • Silver sulfadiazine has an emprical formula of C 10 H 9 AgN 4 O 2 S, molecular weight of 357.14 and structural formula as shown:
  • Structure for silver sulfadiazine

Quoted from the official label, section “Description”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

Details

Made bySt. Mary's Medical Park Pharmacy
Active substanceSilver Sulfadiazine
Used inAntibiotics, antivirals and antifungals taken into the body
Strength10 g/1000g
FormCream
RouteTopical
Packs50 g in 1 TUBE
NDC60760-962

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

Other strengths and forms

4 products are sold under this name. Grouped by form; a number on a strength means several companies make it.

Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.