Bixebra
On the Bulgarian pack: Биксебра 5 mg филмирани таблетки
5 mg film-coated tablets - 180 · film - coated tablets
- Prescription only
- Heart, blood pressure and circulation
- Active substance
- Ivabradine
- Made by
- KRKA, d.d. Novo mesto
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet read the official leaflet for this product. The exact uses and dose are in the leaflet inside the pack. Open the official leaflet
How it works
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (ivabradine). It describes the substance, not this Bulgarian product — its uses and doses can differ.
Ivabradine blocks the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel responsible for the cardiac pacemaker I f current, which regulates heart rate.
In clinical electrophysiology studies, the cardiac effects were most pronounced in the sinoatrial (SA) node, but prolongation of the AH interval has occurred as has PR interval prolongation.
Ivabradine is extensively metabolized in the liver and intestines by CYP3A4-mediated oxidation.
The total clearance of ivabradine is 24 L/h, and renal clearance is approximately 4.2 L/h, with ~ 4% of an oral dose excreted unchanged in urine.
Food delays absorption by approximately 1 hour and increases plasma exposure by 20% to 40%.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-04-24
Safety of the active substance
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (ivabradine). It describes the substance, not this Bulgarian product — its uses and doses can differ.
- Ivabradine is contraindicated in patients with:.
- Acute decompensated heart failure.
- Clinically significant hypotension.
- Sick sinus syndrome, sinoatrial block or 3 rd degree AV block, unless a functioning demand pacemaker is present.
Most common adverse reactions occurring in ≥ 1% of patients are bradycardia, hypertension, atrial fibrillation and luminous phenomena (phosphenes).
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United StatesNo exact match for this strength and form
European UnionNo exact match for this strength and form
SpainNo exact match for this strength and form
CanadaNo exact match for this strength and form
NetherlandsNo exact match for this strength and form
SwitzerlandNo exact match for this strength and form
Details
| Made by | KRKA, d.d. Novo mesto · Slovenia |
|---|---|
| Active substance | Ivabradine |
| Used in | Heart, blood pressure and circulation |
| Strength | 5 mg film-coated tablets - 180 |
| Form | film - coated tablets |
| Pack sizes | 180 |
| Classification | C01EB17 · Heart, blood pressure and circulation |
| Name in the register | Биксебра 5 mg филмирани таблетки |
| Reg. no. | 20160248 |
Source: Bulgarian Drug Agency register · 2026-08-01 · not reviewed by a clinician
Източник: Изпълнителна агенция по лекарствата (ИАЛ). The publisher’s terms do not grant reproduction, so text is shortened and linked. Publisher’s terms.
Other strengths and forms
22 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- film - coated tablets22 products
- 5 mg film-coated tablets - 180
- 5 mg
- 5 mg film-coated tablets - 98
- 5 mg film-coated tablets - 90
- 5 mg film-coated tablets - 60
- 5 mg film-coated tablets - 56
- 5 mg film-coated tablets - 30
- 5 mg film-coated tablets - 28
- 5 mg film-coated tablets - 14
- 5 mg film-coated tablets - 112
- 5 mg film-coated tablets - 100
- 7,5 mg
- 7,5 mg film-coated tablets 14
- 7,5 mg film-coated tablets 30
- 7,5 mg film-coated tablets 180
- 7,5 mg film-coated tablets 112
- 7,5 mg film-coated tablets 100
- 7,5 mg film-coated tablets 98
- 7,5 mg film-coated tablets 90
- 7,5 mg film-coated tablets 60
- 7,5 mg film-coated tablets 56
- 7,5 mg film-coated tablets 28
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.