Principo
On the Bulgarian pack: Принципо 50 mg твърди капсули
50 mg capsules, hard 30x1 · capsules, hard
- Prescription only
- Pain, sleep, mood, epilepsy and the brain
- Active substance
- Pregabalin
- Made by
- STADA Arzneimittel AG
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet read the official leaflet for this product. The exact uses and dose are in the leaflet inside the pack. Open the official leaflet
How it works
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (pregabalin). It describes the substance, not this Bulgarian product — its uses and doses can differ.
Pregabalin binds with high affinity to the alpha 2 -delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.
Although the mechanism of action of pregabalin has not been fully elucidated, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to the alpha 2 -delta subunit may be involved in pregabalin’s anti-nociceptive and antiseizure effects in animals.
Therefore, an increase in the metabolism of coadministered CYP1A2 substrates (e.g. theophylline, caffeine) or CYP 3A4 substrates (e.g., midazolam, testosterone) is not anticipated.
The rate of pregabalin absorption is decreased when given with food, resulting in a decrease in C max of approximately 25% to 30% and an increase in T max to approximately 3 hours.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-04-07
Safety of the active substance
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (pregabalin). It describes the substance, not this Bulgarian product — its uses and doses can differ.
- Pregabalin is contraindicated in patients with known hypersensitivity to pregabalin or any of its components.
- Angioedema and hypersensitivity reactions have occurred in patients receiving pregabalin therapy [see Warnings and Precautions (5.2) ].
- Known hypersensitivity to pregabalin or any of its components.
Most common adverse reactions (greater than or equal to 5% and twice placebo) in pediatric patients for the treatment of partial-onset seizures are increased weight and increased appetite.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United StatesNo exact match for this strength and form
European UnionNo exact match for this strength and form
SpainNo exact match for this strength and form
CanadaNo exact match for this strength and form
NetherlandsNo exact match for this strength and form
SwitzerlandNo exact match for this strength and form
Details
| Made by | STADA Arzneimittel AG · Germany |
|---|---|
| Active substance | Pregabalin |
| Used in | Pain, sleep, mood, epilepsy and the brain |
| Strength | 50 mg capsules, hard 30x1 |
| Form | capsules, hard |
| Pack sizes | 30 |
| Classification | N02BF02 · Pain, sleep, mood, epilepsy and the brain |
| Name in the register | Принципо 50 mg твърди капсули |
| Reg. no. | 20250288 |
Source: Bulgarian Drug Agency register · 2026-08-01 · not reviewed by a clinician
Източник: Изпълнителна агенция по лекарствата (ИАЛ). The publisher’s terms do not grant reproduction, so text is shortened and linked. Publisher’s terms.
Other strengths and forms
32 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- capsules, hard32 products
- 50 mg capsules, hard 30x1
- 50 mg
- 50 mg capsules, hard 14x1
- 50 mg capsules, hard 210x1
- 50 mg capsules, hard 200x1
- 50 mg capsules, hard 100x1
- 50 mg capsules, hard 84x1
- 50 mg capsules, hard 60x1
- 50 mg capsules, hard 56x1
- 50 mg capsules, hard 28x1
- 50 mg capsules, hard 21x1
- 75 mg
- 75 mg capsules, hard 200x1
- 75 mg capsules, hard 100x1
- 75 mg capsules, hard 70x1
- 75 mg capsules, hard 60x1
- 75 mg capsules, hard 56x1
- 75 mg capsules, hard 30x1
- 75 mg capsules, hard 28x1
- 75 mg capsules, hard 14x1
- 75 mg capsules, hard 210x1
- 150 mg
- 150 mg capsules, hard 210x1
- 150 mg capsules, hard 200x1
- 150 mg capsules, hard 100x1
- 150 mg capsules, hard 70x1
- 150 mg capsules, hard 60x1
- 150 mg capsules, hard 56x1
- 150 mg capsules, hard 30x1
- 150 mg capsules, hard 28x1
- 150 mg capsules, hard 21x1
- 150 mg capsules, hard 14x1
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.