Tocieta
On the Bulgarian pack: Тосиета 25 mg филмирани таблетки
25 mg film - coated tablets unit-dose 14 · film - coated tablets
- Prescription only
- Blood, clotting and anaemia
- Active substance
- Eltrombopag
- Used in
- Blood, clotting and anaemia
- Made by
- Zentiva k.s.
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
What it is for
Mediclarum has not yet read the official leaflet for this product. The exact uses and dose are in the leaflet inside the pack. Open the official leaflet
How it works
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (eltrombopag). It describes the substance, not this Bulgarian product — its uses and doses can differ.
Eltrombopag is a TPO-receptor agonist that interacts with the transmembrane domain of the human TPO-receptor (also known as cMpl) and initiates signaling cascades that induce proliferation and differentiation of megakaryocytes leading to increased platelet production.
Absorbed eltrombopag is extensively metabolized, predominantly through pathways, including cleavage, oxidation and conjugation with glucuronic acid, glutathione or cysteine.
Effect of Food A standard high-fat breakfast (876 calories, 52 g fat, 71 g carbohydrate, 34 g protein and 427 mg calcium) significantly decreased plasma eltrombopag AUC 0-INF by approximately 59% and C max by 65% and delayed T max by 1 hour.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-01-21
Safety of the active substance
This product’s leaflet is published as a scanned document. This section quotes the US prescribing label for the same active substance (eltrombopag). It describes the substance, not this Bulgarian product — its uses and doses can differ.
WARNING: RISK FOR HEPATIC DECOMPENSATION IN PATIENTS WITH CHRONIC HEPATITIS C and RISK OF HEPATOTOXICITY In patients with chronic hepatitis C, eltrombopag in combination with interferon and ribavirin may increase the risk of hepatic decompensation [see Warnings and Precautions ( 5.1 )].
The most common serious adverse reaction and most hemorrhagic reactions followed discontinuation of eltrombopag.
Quoted from the US prescribing label for the same active substance. Your own pack’s leaflet is the authority for your product. DailyMed
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
United StatesNo exact match for this strength and form
European UnionNo exact match for this strength and form
SpainNo exact match for this strength and form
CanadaNo exact match for this strength and form
NetherlandsNo exact match for this strength and form
SwitzerlandNo exact match for this strength and form
Details
| Made by | Zentiva k.s. · Czech Republic |
|---|---|
| Active substance | Eltrombopag |
| Used in | Blood, clotting and anaemia |
| Strength | 25 mg film - coated tablets unit-dose 14 |
| Form | film - coated tablets |
| Pack sizes | 14 |
| Classification | B02BX05 · Blood, clotting and anaemia |
| Name in the register | Тосиета 25 mg филмирани таблетки |
| Reg. no. | 20240106 |
Source: Bulgarian Drug Agency register · 2026-08-01 · not reviewed by a clinician
Източник: Изпълнителна агенция по лекарствата (ИАЛ). The publisher’s terms do not grant reproduction, so text is shortened and linked. Publisher’s terms.
Other strengths and forms
12 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- film - coated tablets12 products
- 25 mg film - coated tablets unit-dose 14
- 25 mg
- 25 mg film - coated tablets unit-dose 84
- 25 mg film - coated tablets unit-dose 28
- 50 mg
- 50 mg film - coated tablets unit-dose 14
- 50 mg film - coated tablets unit-dose 84
- 50 mg film - coated tablets unit-dose 28
- 75 mg
- 75 mg film - coated tablets unit-dose 84
- 75mg film - coated tablets unit-dose 28
- 75 mg film - coated tablets unit-dose 14
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.