Medicine guide

Extra Strength Pain Reliever

250 mg + 250 mg + 65 mg · Tablet, Film Coated

Available without prescription
Central Nervous System Stimulant

Active substance: Acetaminophen, Aspirin and Caffeine
Used in: Muscles, joints and bones
Made by: Proficient Rx LP
Source: Official label

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2024-11-01

What it is

PAIN RELIEVER - PAIN RELIEVER AID

How to take it

Adults and children 12 years and over:: take 2 caplets every 6 hours; not more than 8 caplets in 24 hours

Full directions ↓

Do not take it if

If you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer

All warnings ↓

Good to know

Sold without a prescription
FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02

26other products contain Acetaminophen, Aspirin and Caffeine — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

Medicine groupMuscles, joints and bones

This information is not included in the verified source. Open the official leaflet

Do not take it if

if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
with any other drug containing acetaminophen (prescription or nonprescription).
If you are not sure whether a drug contains acetaminophen,
ask a doctor or pharmacist.
if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if
you have liver disease
stomach bleeding warning applies to you
you have a history of stomach problems, such as heartburn
you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
you are taking a diuretic
you have asthma Ask a doctor or pharmacist before use if you are
taking a prescription drug for diabetes, gout, or arthritis
taking any other drug or are under a doctor’s care for any serious condition
Stop use and
ask a doctor if
an allergic reaction occurs. Seek medical help right away.
you experience any of the following signs of stomach bleeding:
feel faint
vomit blood
have bloody or black stools
have stomach pain that does not get better
ringing in the ears or loss of hearing occurs
painful area is red or swollen
pain gets worse or lasts for more than 10 days
fever gets worse or lasts for more than 3 days
new symptoms occur These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Quoted from the official label, section “OTC — Do Not Use”.

How to take it

These directions are for this exact strength and form. Another one is different.

do not use more than directed
drink a full glass of water with each dose
adults and children 12 years and over:
take 2 caplets every 6 hours; not more than 8 caplets in 24 hours
children under 12: ask a doctor

Quoted from the official label, section “Dosage & Administration”.

Other warnings

Reye’s Syndrome:
Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert:
Aspirin may cause a severe allergic reaction which may include:
hives
facial swelling
asthma (wheezing)
shock Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
rash
skin reddening
blisters If a skin reaction occurs,
stop use and seek medical help right away. Liver warning:
This product contains acetaminophen. Severe liver damage may occur
if you take
more than 4,000 mg of acetaminophen in 24 hours
with other drugs containing acetaminophen
3 or more alcoholic drinks every day while using this product Stomach bleeding warning:
This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher
if you
have had stomach ulcers or bleeding problems
take a blood thinning (anticoagulant) or steroid drug
take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
are age 60 or older
have 3 or more alcoholic drinks every day while using this product
take more or for a longer time than directed Caffeine warning:
The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heartbeat.

Quoted from the official label, section “Warnings”.

Keep away from children

In case of accidental overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away. Prompt medical attention is critical for
adults as well as for children even
if you do not notice any signs or symptoms.

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

Other information

store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F)

Quoted from the official label, section “OTC — Other Information”.

What kind of medicine it is

PAIN RELIEVER - PAIN RELIEVER AID

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

corn starch, crospovidone, hypromellose, microcrystalline cellulose, povidone, propylene glycol, sodium lauryl sulfate, sodium starch glycolate, stearic acid, titanium dioxide

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

1-800-540-3765

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

Titanium dioxidetitanium dioxideA whitening agent no longer allowed in food in the EU (E171).

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (87)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

Showing 80 of 80 (the first 80 are listed)

Details

Made by	Proficient Rx LP
Active substance	Acetaminophen, Aspirin and Caffeine
Used in	Muscles, joints and bones
Strength	250 mg + 250 mg + 65 mg
Form	Tablet, Film Coated
Route	Oral
Packs	60 TABLET, FILM COATED in 1 BOTTLE
NDC	82804-163

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

Report wrong or outdated information on this page

Other strengths and forms

9 products are sold under this name. Grouped by form; a number on a strength means several companies make it.

Tablet, Film Coated4 products
- 250 mg + 250 mg + 65 mg2
  250 mg + 250 mg + 65 mg · 2 companies
  - Geri-Care Pharmaceutical Corp
  - Proficient Rx LP · this page
- 500 mg2
  500 mg · 2 companies
  - Lil' Drug Store Products, Inc.
  - Walmart Inc.
Tablet4 products
- 500 mg4
  500 mg · 4 companies
Capsule, Coated1 products
- 250 mg + 250 mg + 65 mg

Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

See every product with Acetaminophen, Aspirin and Caffeine