Medicine guide

Migraine Relief

250 mg + 250 mg + 65 mg · Tablet, Film Coated

Available without prescription
Central Nervous System Stimulant

Active substance: Acetaminophen, Aspirin, Caffeine
Used in: Muscles, joints and bones
Made by: Rite Aid Corporation
Source: Official label

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2026-05-27

What it is

Pain reliever Pain reliever aid

Used for

Treats migraine

How to take it

Adults: take 2 caplets with a glass of water

do not take more than 2 caplets in 24 hours, unless directed by a doctor

Full directions ↓

Do not take it if

If you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer

All warnings ↓

Good to know

Sold without a prescription
FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02

76other products contain Acetaminophen, Aspirin, Caffeine — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

treats migraine

From the official label · 2026-05-27 · DailyMed

Do not take it if

if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
with any other drug containing acetaminophen (prescription or nonprescription).
If you are not sure whether a drug contains acetaminophen,
ask a doctor or pharmacist

Quoted from the official label, section “OTC — Do Not Use”.

How to take it

These directions are for this exact strength and form. Another one is different.

do not use more than directed
adults: take 2 caplets with a glass of water
if symptoms persist or worsen, ask your doctor
do not take more than 2 caplets in 24 hours, unless directed by a doctor
under 18 years of age: ask a doctor

Quoted from the official label, section “Dosage & Administration”.

Ask a doctor first if

you have never had migraines diagnosed by a health professional
you have a headache that is different from your usual migraines
you have the worst headache of your life
you have fever and stiff neck
you have headaches beginning after or caused by head injury, exertion, coughing or bending
you experienced your first headache after the age of 50
you have daily headaches
you have a migraine so severe as to require bed rest
you have liver disease
stomach bleeding warning applies to you
you have a history of stomach problems, such as heartburn
you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
you are taking a diuretic
you have asthma
you have problems or serious side effects from taking pain relievers or fever reducers
you have vomiting with your migraine headache

Quoted from the official label, section “OTC — Ask Doctor”.

Ask a pharmacist first if

you are
taking a prescription drug for:
diabetes
gout
arthritis
under a doctor’s care for any serious condition
taking any other drug
taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer

Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.

Stop and get help if

an allergic reaction occurs. Seek medical help right away.
you experience any of the following signs of stomach bleeding:
feel faint
vomit blood
have bloody or black stools
have stomach pain that does not get better
your migraine is not relieved or worsens after first dose
new or unexpected symptoms occur
ringing in the ears or loss of hearing occurs

Quoted from the official label, section “OTC — Stop Use”.

Other warnings

Reye’s syndrome:
Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product.
When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert:
Acetaminophen may cause severe skin reactions. Symptoms may include:
skin reddening
blisters
rash If a skin reaction occurs,
stop use and seek medical help right away. Allergy alert:
Aspirin may cause a severe allergic reaction which may include:
hives
facial swelling
asthma (wheezing)
shock Liver warning:
This product contains acetaminophen. Severe liver damage may occur
if you take
more than 2 caplets in 24 hours, which is the maximum daily amount
with other drugs containing acetaminophen
3 or more alcoholic drinks every day while using this product Stomach bleeding warning:
This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher
if you
are age 60 or older
have had stomach ulcers or bleeding problems
take a blood thinning (anticoagulant) or steroid drug
take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
have 3 or more alcoholic drinks every day while using this product
take more or for a longer time than directed Medication overuse headache warning:
Headaches may worsen if this product is used for 10 or more days per month. Caffeine warning:
The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.
Do not use
Ask a doctor before use if
Ask a doctor or pharmacist before use
if you are
diabetes
gout
arthritis
Stop use and
ask a doctor if
feel faint
vomit blood
ringing in the ears or loss of hearing occurs If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for

Quoted from the official label, section “Warnings”.

Pregnancy and breastfeeding

If pregnant or breast-feeding, ask a health professional before use.
It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.

Keep away from children

In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for
adults as well as for children even
if you do not notice any signs or symptoms.

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

How to store it

store at 20°-25°C (68°-77°F)
close cap tightly after use
read all product information before using. Keep this box for important information.

Quoted from the official label, section “Storage and Handling”.

What kind of medicine it is

Pain reliever Pain reliever aid

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

carnauba wax, crospovidone, FD&C blue #1 aluminum lake, hypromellose, microcrystalline cellulose, povidone, pregelatinized starch, propylene glycol, saccharin sodium, stearic acid, titanium dioxide

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

1-800-719-9260

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

Colour dyesFD&C blue #1 aluminum lakeSome people react to dyes such as tartrazine (Yellow 5) or carmine.
Titanium dioxidetitanium dioxideA whitening agent no longer allowed in food in the EU (E171).

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (87)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

Showing 80 of 80 (the first 80 are listed)

Details

Made by	Rite Aid Corporation
Active substance	Acetaminophen, Aspirin, Caffeine
Used in	Muscles, joints and bones
Strength	250 mg + 250 mg + 65 mg
Form	Tablet, Film Coated
Route	Oral
Packs	1 BOTTLE in 1 CARTON / 100 TABLET, FILM COATED in 1 BOTTLE · 1 BOTTLE in 1 CARTON / 24 TABLET, FILM COATED in 1 BOTTLE
NDC	11822-0374

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

Report wrong or outdated information on this page

Other strengths and forms

14 products are sold under this name. Grouped by form; a number on a strength means several companies make it.

Tablet7 products
- 6X + 6X + 3X + 6X + 3X + 12X + 6X + 6X + 3X + 3X
- 250 mg + 250 mg + 65 mg6
  250 mg + 250 mg + 65 mg · 6 companies
Tablet, Film Coated4 products
- 250 mg + 250 mg + 65 mg4
  250 mg + 250 mg + 65 mg · 4 companies
  - CVS Pharmacy
  - Kroger Company
  - Rite Aid Corporation · this page
  - Walgreen Company
Capsule, Liquid Filled2 products
- 200 mg2
  200 mg · 2 companies
  - Bionpharma Inc.
  - WALGREENS
Powder1 products
- 2X/6g + 4X/6g + 4X/6g + 5X/6g + 3X/6g

Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

See every product with Acetaminophen, Aspirin, Caffeine