Nighttime Sleep Aid
50 mg · Capsule
- Available without prescription
- Histamine-1 Receptor Antagonist
- Active substance
- Diphenhydramine Hcl
- Made by
- Cardinal Health (Leader) 70000
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
At a glance
Quoted from the official label · 2025-05-16
Nighttime sleep-aid
- For relief of occasional sleeplessness.
Adults and children 12 years of age and over:: 1 softgel (50 mg) at bedtime if needed, or as directed by a doctor
Full directions ↓Children under 12 years of age with any other product containing diphenhydramine, even one used on skin
All warnings ↓- Sold without a prescription
- FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed
What it is for
- for relief of occasional sleeplessness.
From the official label · 2025-05-16 · DailyMed
How it works
From the US prescribing label for the same active substance (Diphenhydramine HCL). It describes the substance, not this exact product.
Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative effects.
Antihistamines appear to compete with histamine for cell receptor sites on effector cells.
Little, if any, is excreted unchanged in the urine; most appears as the degradation products of metabolic transformation in the liver, which are almost completely excreted within 24 hours.
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-03
Do not take it if
- for
- children under 12 years of age with any other product containing diphenhydramine, even one used on skin
Quoted from the official label, section “OTC — Do Not Use”.
How to take it
These directions are for this exact strength and form. Another one is different.
- adults and children 12 years of age and over:
- 1 softgel (50 mg) at bedtime if needed, or as directed by a doctor
Quoted from the official label, section “Dosage & Administration”.
Ask a doctor first if
a breathing problem such as emphysema or chronic bronchitis glaucoma trouble urinating due to an enlarged prostate gland
Quoted from the official label, section “OTC — Ask Doctor”.
Ask a pharmacist first if
you are taking sedatives or tranquilizers.
Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.
Stop and get help if
sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of a serious underlying medical illness.
Quoted from the official label, section “OTC — Stop Use”.
Other warnings
- Do not use for
- Ask a doctor before use
- if you have a breathing problem such as emphysema or chronic bronchitis glaucoma trouble urinating due to an enlarged prostate gland
- Ask a doctor or pharmacist before use
- if you are taking sedatives or tranquilizers.
- When using this product avoid alcoholic drinks.
- Stop use and ask a doctor if sleeplessness persists continuously for more than 2 weeks.
- Keep out of reach of children.
- avoid alcoholic drinks.
Quoted from the official label, section “Warnings”.
Pregnancy and breastfeeding
If pregnant or breast-feeding, ask a health professional before use.
Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.
Keep away from children
In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.
Quoted from the official label, section “OTC — Keep Out of Reach of Children”.
How to store it
store between 15-30°C (59-86°F)
Quoted from the official label, section “Storage and Handling”.
What kind of medicine it is
Nighttime sleep-aid
Quoted from the official label, section “OTC — Purpose”.
Other ingredients
Relevant if you react to a dye, a preservative, lactose or gluten.
FD&C blue #1, gelatin, glycerin, lecithin, light mineral oil, mannitol, polyethylene glycol, purified water, sorbitol sorbitan, white ink
Quoted from the official label, section “Inactive Ingredients”.
Questions about this product
Call 1-877-753-3935 Monday-Friday 9AM-5PM EST
Quoted from the official label, section “OTC — Questions”.
Ingredients people check for
Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.
- Colour dyes
FD&C blue #1
Some people react to dyes such as tartrazine (Yellow 5) or carmine. - Sugar alcohols
mannitol; sorbitol sorbitan
Sorbitol and similar can upset the stomach and matter with fructose intolerance. - Gelatin
gelatin
Animal-derived: matters for vegetarian, vegan, halal and kosher diets. - Soy
lecithin
Matters with a soy allergy.
Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.
Every version of this medicine (80)
The same active substance, strength and kind of form, from every company that sells it — with what each label lists.
Showing 80 of 80
- Nighttime Sleep AidThis oneWithout prescriptionCardinal Health (Leader) 70000Colour dyesSugar alcoholsGelatinSoy
- Diphenhydramine HclWithout prescriptionAARNA USA INC.LactoseGelatin
- Diphenhydramine HydrochlorideWithout prescriptionAdvance Pharmaceutical Inc.LactoseColour dyesGelatinParabens
- Diphenhydramine HclWithout prescriptionAkron Pharma Inc.LactoseGelatin
- Sleep AidWithout prescriptionAllegiant HealthColour dyesSugar alcoholsGelatin
- Nighttime Sleep-AidWithout prescriptionAMERISOURCE BERGENColour dyesSugar alcoholsGelatinSoyTitanium dioxide
- Diphenhydramine Hydrochloride 50mgWithout prescriptionAMZ789 LLCColour dyesSugar alcoholsGelatin
- Sleepaid (diphenhydramine Hcl)Without prescriptionAPNAR PHARMA LPColour dyesSugar alcoholsGelatin
- Nighttime Sleep Aid Maximum StrengthWithout prescriptionBest Choice (Valu Merchandisers Company)Colour dyesSugar alcoholsGelatin
- Nighttime Sleep-AidWithout prescriptionBionpharma Inc.Colour dyesSugar alcoholsGelatinSoyTitanium dioxide
- Allergy ReliefWithout prescriptionBIONPHARMA INC.Sugar alcoholsGelatin
- BanophenWithout prescriptionBryant Ranch PrepackLactoseColour dyesGelatin
- Nighttime Sleep Aid Maximum StrengthWithout prescriptionCardinal Health (Leader) 70000Colour dyesSugar alcoholsGelatinSoy
- Diphenhydramine HclWithout prescriptionCardinal Health 107, LLCLactoseColour dyesGelatin
- Nighttime Sleep AidWithout prescriptionCare One (Retail Business Services, LLC.)Colour dyesSugar alcoholsGelatin
- Nighttime Sleep Aid Maximum StrengthWithout prescriptionCare One (Retail Business Services, LLC.)Colour dyesSugar alcoholsGelatinSoy
- Sleep Aid NighttimeWithout prescriptionCVS PharmacyColour dyesSugar alcoholsGelatin
- Discount Drugmart Nighttime Sleep-AidWithout prescriptionDiscount Drug Mart, IncColour dyesSugar alcoholsGelatin
- Nighttime Sleep-AidWithout prescriptionDISCOUNT DRUG MART, INC.Colour dyesSugar alcoholsGelatin
- Sleep AidWithout prescriptionDolgencorp, Inc. (DOLLAR GENERAL & REXALL)Colour dyesSugar alcoholsGelatinSoy
- Sleep Aid NighttimeWithout prescriptionDolgencorp, Inc. (DOLLAR GENERAL & REXALL)Colour dyesSugar alcoholsGelatinSoy
- Diphenhydramine HydrochlorideWithout prescriptionEpic Pharma, LLCLactoseColour dyesGelatinParabens
- Sleep AidWithout prescriptionEQUATE (Wal-Mart Stores, Inc.) (see also WAL-MART INC)Colour dyesSugar alcoholsGelatinSoy
- Sleep AidWithout prescriptionFamily Dollar (FAMILY WELLNESS)Colour dyesSugar alcoholsGelatinSoy
- Sleep AidWithout prescriptionFSA Store Inc. (Caring Mills)Colour dyesSugar alcoholsGelatinSoy
- AntihistamineWithout prescriptionGendose Pharmaceuticals, LLCLactoseColour dyesGelatin
- Nighttime Sleep AidWithout prescriptionGood Sense (Geiss, Destin & Dunn, Inc.)Colour dyesSugar alcoholsGelatin
- Nighttime Sleep AidWithout prescriptionGrocery OutletColour dyesSugar alcoholsGelatin
- Sleep Aid Maximum StrengthWithout prescriptionH E BColour dyesSugar alcoholsGelatin
- Nighttime Sleep Aid Maximum StrengthWithout prescriptionHarris Teeter, LLCColour dyesSugar alcoholsGelatinSoy
- Sleep Aid Maximum StrengthWithout prescriptionHarris Teeter, LLCColour dyesSugar alcoholsGelatin
- Diphenhydramine HydrochlorideWithout prescriptionHumanwell PuraCap Pharmaceutical (Wuhan), Ltd.Colour dyesSugar alcoholsGelatin
- Hyvee Maximum Strength Nighttime Sleep-Aid SoftgelWithout prescriptionHyVee IncColour dyesSugar alcoholsGelatinTitanium dioxide
- Benadryl Allergy Extra Strength Liqui-GelsWithout prescriptionKenvue Brands LLCColour dyesSugar alcoholsGelatin
- Nighttime Sleep-AidWithout prescriptionKROGER COMPANYColour dyesSugar alcoholsGelatin
- BanophenWithout prescriptionMajor PharmaceuticalsLactoseColour dyesGelatin
- Diphenhydramine HydrochlorideWithout prescriptionMajor PharmaceuticalsLactoseColour dyesGelatin
- Diphenhydramine HclWithout prescriptionNuCare Pharmaceuticals, Inc.LactoseGelatin
- Sleepaid SoftgelsWithout prescriptionNUVICARE LLCSugar alcoholsGelatin
- Nighttime Sleep AidWithout prescriptionP & L Development, LLCColour dyesSugar alcoholsGelatinSoy
- Sleep Aid Maximum StrengthWithout prescriptionP & L Development, LLCColour dyesSugar alcoholsGelatin
- Diphenhydramine HclWithout prescriptionPD-Rx Pharmaceuticals, Inc.LactoseGelatin
- PharbedrylWithout prescriptionPharbest Pharmaceuticals, Inc.LactoseGelatin
- Sleepaid SoftgelsWithout prescriptionPIONEER LIFE SCIENCES, LLCSugar alcoholsGelatin
- BanophenWithout prescriptionPreferred Pharmaceuticals Inc.LactoseColour dyesGelatin
- Diphenhydramine HclWithout prescriptionPreferred Pharmaceuticals, Inc.LactoseGelatin
- Diphenhydramine HydrochlorideWithout prescriptionProdose, Inc.Sugar alcoholsGelatin
- Nighttime Sleep AidWithout prescriptionProdose, Inc.Colour dyesSugar alcoholsGelatinTitanium dioxide
- Diphenhydramine HclWithout prescriptionProficient Rx LPLactoseGelatin
- Nighttime Sleep AidWithout prescriptionPuraCap Pharmaceutical LLCColour dyesSugar alcoholsGelatin
- Sleep AidWithout prescriptionQUALITY CHOICE (Chain Drug Marketing Association)Colour dyesSugar alcoholsGelatinSoy
- Sleep Aid Maximum StrengthWithout prescriptionQUALITY CHOICE (Chain Drug Marketing Association)Colour dyesSugar alcoholsGelatinSoy
- Diphenhydramine HydrochlorideWithout prescriptionRichmond Pharmaceuticals Inc.LactoseColour dyesGelatinParabens
- Diphenhydramine HydrochlorideWithout prescriptionRichmond Pharmaceuticals, Inc.LactoseColour dyesGelatinParabens
- DimetaneWithout prescriptionRising Pharma Holdings, Inc.Colour dyesSugar alcoholsGelatin
- Sleep AidWithout prescriptionSafeway, Inc.Colour dyesSugar alcoholsGelatinSoy
- Diphenhydramine HclWithout prescriptionSDA Laboratories, Inc.LactoseGelatin
- Nighttime Sleep AidWithout prescriptionShield Pharmaceuticals CorpColour dyesSugar alcoholsAlcohol (ethanol)GelatinTitanium dioxide
- Diphenhydramine HydrochlorideWithout prescriptionSOFTGEL HEALTHCARE PRIVATE LIMITEDSugar alcoholsGelatin
- Diphenhydramine HydrochlorideWithout prescriptionSoftgel Healthcare Pvt LtdSugar alcoholsGelatin
- Sleep AidWithout prescriptionStrategic Sourcing Services LLCColour dyesSugar alcoholsGelatinSoy
- Diphenhydramine HydrochlorideWithout prescriptionStrive Pharmaceuticals Inc.Colour dyesSugar alcoholsGelatin
- Right Remedies Maximum Strength Nighttime Sleep-Aid SoftgelWithout prescriptionStrive Pharmaceuticals Inc.Colour dyesSugar alcoholsGelatinTitanium dioxide
- Sleep AidWithout prescriptionTARGET CorporationColour dyesSugar alcoholsGelatinSoy
- Kroger Nighttime Sleep-AidWithout prescriptionTHE KROGER COColour dyesSugar alcoholsGelatin
- Sleep AidWithout prescriptionThe Kroger Co.Colour dyesSugar alcoholsGelatinSoy
- Nighttime Sleep AidWithout prescriptionTOP CARE (Topco Associates LLC)Colour dyesSugar alcoholsGelatinSoy
- Topcare Health Nighttime Maximum Strength Sleep AidWithout prescriptionTopco Associates LLCColour dyesSugar alcoholsGelatinTitanium dioxide
- Sleep Aid NighttimeWithout prescriptionTOPCO ASSOCIATES LLCColour dyesSugar alcoholsGelatinTitanium dioxide
- PharbedrylWithout prescriptionUlai Health LLCLactoseColour dyesGelatin
- Sleep Aid NighttimeWithout prescriptionUnited Natural Foods, Inc. dba UNFIColour dyesSugar alcoholsGelatin
- Nighttime Sleep-AidWithout prescriptionVALU MERCHANDISERS COMPANYColour dyesSugar alcoholsGelatin
- Nightime Sleep AidWithout prescriptionVelocity PharmaSugar alcoholsGelatinTitanium dioxide
- Allergy ReliefWithout prescriptionWALGREEN COMPANYSugar alcoholsGelatin
- Wal Som Nighttime Sleep AidWithout prescriptionWalgreensColour dyesSugar alcoholsGelatinSoy
- Wal Som Nighttime Sleep Aid NighttimeWithout prescriptionWalgreensColour dyesSugar alcoholsGelatin
- Nighttime Sleep-AidWithout prescriptionWhole Foods Market, INC.Sugar alcoholsGelatin
- Sleep Aid Maximum StrengthWithout prescriptionWinCo Foods, LLCColour dyesSugar alcoholsGelatin
- Nighttime Sleep AidWithout prescriptionWR Group, Inc.Colour dyesSugar alcoholsGelatinSoy
- Allergy Relief Diphenhydramine Hcl 50 MgWithout prescriptionYYBA CorporationLactoseGelatin
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
Canada15 matching products
- SLEEP AID EXTRA STRENGTH 50 mg · capsuleWithout prescription2 makers
- ALLERGY CAPSULES EXTRA STRENGTH 50 mg · capsuleWithout prescription
- DIPHENHYDRAMINE HYDROCHLORIDE 50 mg · capsuleWithout prescription
- DORMIPHEN EXTRA-FORT CAPSULE 50 mg · capsuleWithout prescription
- EXTRA STRENGTH ALLERGY FORMULA LIQUID CAPSULES 50 mg · capsuleWithout prescription
- EXTRA STRENGTH DORMEX CAPSULES 50 mg · capsuleWithout prescription
- EXTRA STRENGTH NIGHTTIME ALLERGY LIQUID GEL CAPSULES 50 mg · capsuleWithout prescription
- EXTRA STRENGTH NYTOL QUICKGELS 50 mg · capsuleWithout prescription
Details
| Made by | Cardinal Health (Leader) 70000 |
|---|---|
| Active substance | Diphenhydramine Hcl |
| Used in | Breathing, airways, allergies and cough |
| Strength | 50 mg |
| Form | Capsule |
| Route | Oral |
| Packs | 100 CAPSULE in 1 BOTTLE, PLASTIC |
| NDC | 70000-0616 |
Source: NDC Directory · 2026-09-13 · not reviewed by a clinician
Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).
Other strengths and forms
53 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- Tablet16 products
- Capsule, Liquid Filled8 products
25 mg4
50 mg4
- Solution8 products
50 mg/30mL8
- Capsule6 products
50 mg6
50 mg · 6 companies
- Cardinal Health (Leader) 70000 · this page
- Care One (Retail Business Services, LLC.)
- Good Sense (Geiss, Destin & Dunn, Inc.)
- P & L Development, LLC
- TOP CARE (Topco Associates LLC)
- WR Group, Inc.
Show all forms · 7 forms
- Liquid6 products
50 mg/30mL6
- Tablet, Film Coated5 products
25 mg5
- Tablet, Coated4 products
25 mg4
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.