Mediclarum
Medicine guide

Topcare Nite Time Severe Cold and Flu

325 mg + 10 mg + 6.25 mg + 5 mg · Capsule, Liquid Filled

  • Available without prescription
  • Antihistamine
Made by
Topco Associates LLC

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2023-11-03

What it is

Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant

Used for
  • Nasal congestion
  • Sinus congestion & pressure
  • Cough due to minor throat & bronchial irritation
  • Cough to help you sleep
  • Minor aches & pains
+7 more
How to take it

Adults & children 12 yrs & over 2 softgels with water every 4 hours

Full directions ↓
Warning

This product contains acetaminophen. Severe liver damage may occur

All warnings ↓
Good to know
  • Sold without a prescription
  • FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
42other products contain Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine Hydrochloride — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

temporarily relieves common cold/flu symptoms:

  • nasal congestion
  • sinus congestion & pressure
  • cough due to minor throat & bronchial irritation
  • cough to help you sleep
  • minor aches & pains
  • headache
  • fever
  • sore throat
  • runny nose & sneezing
  • reduces swelling of nasal passages
  • temporarily restores freer breathing through the nose
  • promotes nasal and/or sinus drainage

From the official label · 2023-11-03 · DailyMed

How to take it

These directions are for this exact strength and form. Another one is different.

  • take only as directed
  • do not exceed 8 softgels per 24 hrs
  • adults & children 12 yrs & over 2 softgels with water every 4 hours
  • children 4 to under 12 yrs
  • ask a doctor
  • children under 4 yrs
  • do not use

Quoted from the official label, section “Dosage & Administration”.

Other warnings

  • Liver warning:
  • This product contains acetaminophen. Severe liver damage may occur
  • if you take
  • more than 8 softgels in 24 hours, which is the maximum daily amount for this product
  • with other drugs containing acetaminophen
  • 3 or more alcoholic drinks every day while using this product Allergy alert:
  • Acetaminophen may cause severe skin reactions. Symptoms may include:
  • skin reddening
  • blisters
  • rash If a skin reaction occurs,
  • stop use and seek medical help right away. Sore throat warning:
  • If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
  • Do not use
  • with any other drug containing acetaminophen (prescription or nonprescription).
  • If you are not sure whether a drug contains acetaminophen,
  • ask a doctor or pharmacist.
  • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug.
  • If you do not know if your prescription drug contains an MAOI,
  • ask a doctor or pharmacist before taking this product.
  • Ask a doctor before use
  • if you have
  • liver disease
  • heart disease
  • high blood pressure
  • thyroid disease
  • diabetes
  • glaucoma
  • a sodium-restricted diet
  • trouble urinating due to enlarged prostate gland
  • cough that occurs with too much phlegm (mucus)
  • a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, chronic bronchitis, or emphysema
  • Ask a doctor or pharmacist before use
  • if you are
  • taking sedatives or tranquilizers
  • taking the blood thinning drug warfarin When using this product
  • do not use more than directed
  • excitability may occur, especially in children
  • marked drowsiness may occur
  • avoid alcoholic drinks
  • be careful when driving a motor vehicle or operating machinery
  • alcohol, sedatives, and tranquilizers may increase drowsiness
  • Stop use and
  • ask a doctor if
  • you get nervous, dizzy or sleepless
  • pain, nasal congestion, or cough gets worse or lasts more than 7 days
  • fever gets worse or lasts more than 3 days
  • redness or swelling is present
  • new symptoms occur
  • cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. If pregnant or breast-feeding , ask a health professional before use.
  • Keep out of reach of children. Overdose warning:

Quoted from the official label, section “Warnings”.

Keep away from children

  • Overdose warning:
  • In case of overdose, get medical help or contact a Poison Control Center right away.

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

How to store it

  • store at 20-25°C (68-77°F)
  • protect from light, heat and moisture

Quoted from the official label, section “Storage and Handling”.

What kind of medicine it is

Pain reliever/fever reducer Cough suppressant Antihistamine Nasal decongestant

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

edible printing ink, FD&C blue no. 1, gelatin, glycerin, polyethylene glycol 400, povidone K30, propylene glycol, purified water, sorbitol sorbitan solution

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

Call 1-888-423-0139

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

  • Colour dyesFD&C blue no. 1Some people react to dyes such as tartrazine (Yellow 5) or carmine.
  • Sugar alcoholssorbitol sorbitan solutionSorbitol and similar can upset the stomach and matter with fructose intolerance.
  • GelatingelatinAnimal-derived: matters for vegetarian, vegan, halal and kosher diets.

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (14)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

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Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

Medicine passport: one printable page to show a pharmacist abroad

CanadaNo exact match for this strength and form

Every strength and form (6)

Details

Made byTopco Associates LLC
Active substanceAcetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine Hydrochloride
Used inBreathing, airways, allergies and cough
Strength325 mg + 10 mg + 6.25 mg + 5 mg
FormCapsule, Liquid Filled
RouteOral
Packs2 BLISTER PACK in 1 CARTON / 12 CAPSULE, LIQUID FILLED in 1 BLISTER PACK
NDC76162-812

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

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Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

Alka Seltzer Cold Cold Flu and Congestion Severe Night Fast Gels5 mg + 325 mg + 10 mg + 6.25 mgWithout prescriptionCapsule, Liquid Filled Bayer HealthCare LLC. · Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine HydrochlorideAlka-Seltzer Plus Maximum Strength Night Cold and Flu10 mg + 325 mg + 6.25 mg + 5 mgWithout prescriptionCapsule, Liquid Filled Bayer HealthCare LLC. · Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine HydrochlorideAlka-Seltzer Plus Maximum Strength Night Cold and Flu Powermax Gels5 mg + 325 mg + 10 mg + 6.25 mgWithout prescriptionCapsule, Liquid Filled Bayer HealthCare LLC. · Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine HydrochlorideAlka-Seltzer Plus Maximum Strength Severe Sinus Congestion and Cough Day and NightWithout prescriptionKit Bayer HealthCare LLC. · Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine HydrochlorideAlka-Seltzer Plus Maximum Strength Severe Sinus, Allergy and Cough325 mg + 10 mg + 6.25 mg + 5 mgWithout prescriptionCapsule, Liquid Filled Bayer HealthCare LLC. · Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine HydrochlorideAsp Nighttime Max325 mg + 10 mg + 6.25 mg + 5 mgWithout prescriptionCapsule, Liquid Filled Humanwell PuraCap Pharmaceutical (Wuhan), Ltd. · Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, Phenylephrine Hydrochloride

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