Mediclarum
Medicine guide

Dr Simi All Day Pain Relief

220 mg · Tablet, Film Coated

  • Available without prescription
  • Nonsteroidal Anti-inflammatory Drug
Active substance
Naproxen Sodium
Made by
Farmacias De Similares TX LLC

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2025-08-15

What it is

Pain reliever/fever reducer

Used for
  • Do not take more than directed.
  • The smallest effective dose should be used Drink a full glass of water with each dose.
  • Take 1 caplet every 8 to 12 hours while symptoms last.
  • For the first dose you may take 2 caplets within the first hour.
  • Do not exceed 2 caplets in any 8-12 hour period.
+2 more
How to take it

Adults and children 12 years and over:: take 1 caplet every 8 to 12 hours while symptoms last.

Full directions ↓
Do not take it if

If you have ever had an allergic reaction to any other pain reliever/fever reducer. Right before or after heart surgery.

All warnings ↓
Good to know
  • Sold without a prescription
  • FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
214other products contain Naproxen Sodium — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

Adults and children 12 years and over:

  • Do not take more than directed.
  • The smallest effective dose should be used Drink a full glass of water with each dose.
  • Take 1 caplet every 8 to 12 hours while symptoms last.
  • For the first dose you may take 2 caplets within the first hour.
  • Do not exceed 2 caplets in any 8-12 hour period.
  • Do not exceed 3 caplets in a 24-hour period.
  • Children under 12 years: Ask a doctor.

From the official label · 2025-08-15 · DailyMed

How it works

From the US prescribing label for the same active substance (Naproxen). It describes the substance, not this exact product.

Naproxen has analgesic, anti-inflammatory, and antipyretic properties.

The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Peak level after2–4 h
Half-life12–17 h
Mostly cleared after≈ 3 daysfive half-lives — our arithmetic
PeakHalf gone3 days0
The shape is a standard model drawn from the two times above, not a measurement. How fast a medicine acts and wears off also depends on the dose, the form and the person.
How the body breaks it down

Naproxen is extensively metabolized in the liver to 6-0-desmethyl naproxen, and both parent and metabolites do not induce metabolizing enzymes.

How it leaves the body

Approximately 95% of the naproxen from any dose is excreted in the urine, primarily as naproxen (<1%), 6-0-desmethyl naproxen (<1%) or their conjugates (66% to 92%).

Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-18

Do not take it if

If you have ever had an allergic reaction to any other pain reliever/fever reducer. Right before or after heart surgery.

Quoted from the official label, section “OTC — Do Not Use”.

How to take it

These directions are for this exact strength and form. Another one is different.

  • Adults and children 12 years and over:
  • Take 1 caplet every 8 to 12 hours while symptoms last.
  • For the first dose you may take 2 caplets within the first hour.
  • Do not exceed 2 caplets in any 8-12 hour period.
  • Do not exceed 3 caplets in a 24-hour period.
  • Children under 12 years: Ask a doctor.

Quoted from the official label, section “Dosage & Administration”.

Ask a doctor first if

  • The stomach bleeding warning applies to you.
  • You have a history of stomach problems, such as heartburn
  • You have high blood pressure, heart disease, liver cirrhosis, or kidney disease.
  • You are taking a diuretic
  • You have problems or serious side effects from taking pain relievers or fever reducers.
  • You have asthma.

Quoted from the official label, section “OTC — Ask Doctor”.

Ask a pharmacist first if

you are Under a doctor's care for any serious condition. Taking any other drug.

Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.

Stop and get help if

  • and ask doctor
  • if You experience any of the following signs of stomach bleeding:
  • Feel faint.
  • Have bloody or black stools.
  • Vomit blood.
  • Have stomach pain that does not get better.
  • You have symptoms of heart problems or stroke:
  • Chest Pain Trouble breathing Weakness in one side of the body Slurred speech Leg swelling Pain gets worse or lasts more than 10 days.
  • Fever gets worse or lasts more than 3 days.
  • You have difficulty swallowing.
  • It feels like the pill is stuck in your throat.
  • Redness or swelling is present in the painful area.
  • Any new symptoms appear.

Quoted from the official label, section “OTC — Stop Use”.

Other warnings

  • Allergy alert:
  • Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin.
  • Symptoms may include:
  • Hives Facial swelling Asthma (wheezing) Shock Skin reddening Rash Blisters If an allergic reaction occurs,
  • stop use and seek medical help right away.
  • Stomach bleeding warning:
  • This product contains an NSAID, which may cause severe stomach bleeding.
  • The chance is higher if you: Are age 60 or older.
  • Have had stomach ulcers or bleeding problems.
  • Take a blood thinning (anticoagulant) or steroid drug.
  • Take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others].
  • Have 3 or more alcoholic drinks every day while using this product.
  • Take more or for a longer time than directed.
  • Do not use
  • Ask a doctor before use if The stomach bleeding warning applies to you.
  • Ask a doctor or pharmacist before use
  • if you are Under a doctor's care for any serious condition.
  • Taking any other drug.
  • When using this product Take with food or milk if stomach upset occurs.
  • The risk of heart attack or stroke may increase
  • if you use more than directed or for longer than directed.
  • Stop use and ask doctor
  • Feel faint.
  • Vomit blood.
  • Keep out of reach of children In case of overdose, get medical help or contact a Poison Control Center immediately.
  • Take with food or milk if stomach upset occurs. The risk of heart attack or stroke may increase
  • if you use more than directed or for longer than directed.

Quoted from the official label, section “Warnings”.

Pregnancy and breastfeeding

  • If pregnant or breast-feeding ask a health professional before use.
  • It is especially important not to use Naproxen sodium during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.

If you take too much

In an emergency, call your local emergency number or a poison control centre.

In case of overdose, get medical help or contact a Poison Control Center immediately.

Quoted from the official label, section “Overdosage”.

Keep away from children

Keep out of reach of children

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

Other information

  • Each tablet contains:
  • sodium 20 mg.
  • Store at room temperature 15-30°C (59-86°F). Read all product information before use.

Quoted from the official label, section “OTC — Other Information”.

What kind of medicine it is

Pain reliever/fever reducer

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

Colloidal silicon dioxide, croscarmellose sodium, FD&C Blue No. 2 Lake, hypromellose, magnesium stearate, mirocrystalline cellulose, polyethylene glycol, povidone, titanium dioxide.

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

(855)-280-1079

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

  • Colour dyesFD&C Blue No. 2 LakeSome people react to dyes such as tartrazine (Yellow 5) or carmine.
  • Titanium dioxidetitanium dioxideA whitening agent no longer allowed in food in the EU (E171).

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (147)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

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Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

Medicine passport: one printable page to show a pharmacist abroad

Canada7 matching products

Every strength and form (45)

NetherlandsNo exact match for this strength and form

Every strength and form (24)

Details

Made byFarmacias De Similares TX LLC
Active substanceNaproxen Sodium
Used inMuscles, joints and bones
Strength220 mg
FormTablet, Film Coated
RouteOral
Packs24 TABLET, FILM COATED in 1 BOTTLE
NDC85786-104

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

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