Medicine guide

Naproxen Caplets

220 mg · Tablet

Available without prescription
Nonsteroidal Anti-inflammatory Drug

Active substance: Naproxen Sodium 220 Mg
Used in: Muscles, joints and bones
Made by: Allegiant Health
Source: Official label

Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.

At a glance

Quoted from the official label · 2019-06-06

What it is

Pain reliever/fever reducer

Used for

Minor pain of arthritis muscular aches backache menstrual cramps headache toothache the common cold temporarily reduces fever

How to take it

Adults and children 12 years and older:: take 1 caplet every 8 to 12 hours while symptoms last for the first dose you may

Full directions ↓

Do not take it if

If you have ever had an allergic reaction to any other pain reliever/fever reducer right before or after heart surgery

All warnings ↓

Good to know

Sold without a prescription
FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02

1other products contain Naproxen Sodium 220 Mg — compare makers, forms and strengths

Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed

What it is for

temporarily relieves minor aches and pains due to:

minor pain of arthritis muscular aches backache menstrual cramps headache toothache the common cold temporarily reduces fever

From the official label · 2019-06-06 · DailyMed

How it works

From the US prescribing label for the same active substance (Naproxen). It describes the substance, not this exact product.

Naproxen has analgesic, anti-inflammatory, and antipyretic properties.
The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Peak level after2–4 h

Half-life12–17 h

Mostly cleared after≈ 3 daysfive half-lives — our arithmetic

The shape is a standard model drawn from the two times above, not a measurement. How fast a medicine acts and wears off also depends on the dose, the form and the person.

How the body breaks it down

Naproxen is extensively metabolized in the liver to 6-0-desmethyl naproxen, and both parent and metabolites do not induce metabolizing enzymes.

How it leaves the body

Approximately 95% of the naproxen from any dose is excreted in the urine, primarily as naproxen (<1%), 6-0-desmethyl naproxen (<1%) or their conjugates (66% to 92%).

Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-18

Do not take it if

if you have ever had an allergic reaction to any other pain reliever/fever reducer right before or after heart surgery

Quoted from the official label, section “OTC — Do Not Use”.

How to take it

These directions are for this exact strength and form. Another one is different.

do not take more than directed
the smallest effective dose should be used drink a full glass of water with each dose
Adults and children 12 years and older:
take 1 caplet every 8 to 12 hours while symptoms last for the first dose you may
take 2 caplets within the first hour
do not exceed 2 caplets in any 8 to 12 hour period
do not exceed 3 caplets in a 24 hour period
Children under 12 years :
ask a doctor

Quoted from the official label, section “Dosage & Administration”.

Ask a doctor first if

the stomach bleeding warning applies to you
you have a history of stomach problems, such as heartburn
you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
you are taking a diuretic
you have problems or serious side effects from taking pain relievers or fever reducers
you have asthma

Quoted from the official label, section “OTC — Ask Doctor”.

Ask a pharmacist first if

under a doctor’s care for any serious condition taking aspirin for heart attack or stroke, because naproxen may decrease this benefit of aspirin taking any other drug

Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.

Stop and get help if

you experience any of the following signs of stomach bleeding:
feel faint vomit blood have bloody or black stools have stomach pain that does not get better
you have symptoms of heart problems or stroke:
chest pain trouble breathing weakness in one part or side of body slurred speech leg swelling pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present in the painful area any new symptoms appear

Quoted from the official label, section “OTC — Stop Use”.

Other warnings

Allergy alert:
Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin.
Symptoms may include hives facial swelling asthma (wheezing) shock skin reddening rash blisters If an allergic reaction occurs,
stop use and seek medical help right away.
Stomach bleeding warning:
This product contains an NSAID, which may cause severe stomach bleeding.
The chance is higher
if you are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed.
Heart attack and stroke warning:
NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke.
These can be fatal.
The risk is higher if you use more than directed or for longer than directed.
Do not use
Ask a doctor before use if the stomach bleeding warning applies to you
Ask a doctor or pharmacist before use if under a doctor’s care for any serious condition taking aspirin for heart attack or stroke, because naproxen may decrease this benefit of aspirin taking any other drug
When using this product take with food or milk if stomach upset occurs the risk of heart attack or stroke may increase
if you use more than directed or for longer than directed
Stop use and
ask a doctor
if you experience any of the following signs of stomach bleeding:
chest pain trouble breathing weakness in one part or side of body slurred speech leg swelling pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present in the painful area any new symptoms appear Pregnancy/Breastfeeding ask a health professional before use.
Keep out of reach of children In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.
take with food or milk if stomach upset occurs the risk of heart attack or stroke may increase
if you use more than directed or for longer than directed

Quoted from the official label, section “Warnings”.

Pregnancy and breastfeeding

/Breastfeeding ask a health professional before use.
It is especially important not to use naproxen sodium during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.

Keep away from children

In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

Quoted from the official label, section “OTC — Keep Out of Reach of Children”.

What kind of medicine it is

Pain reliever/fever reducer

Quoted from the official label, section “OTC — Purpose”.

Other ingredients

Relevant if you react to a dye, a preservative, lactose or gluten.

corn starch, FD&C blue #2 aluminum lake, hypromellose, microcrystalline cellulose, polyethylene glycol, povidone, purified water, sodium starch glycolate, stearic acid, titanium dioxide

Quoted from the official label, section “Inactive Ingredients”.

Questions about this product

Call 1-888-952-0050 Monday through Friday 9AM- 5PM EST.

Quoted from the official label, section “OTC — Questions”.

Ingredients people check for

Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.

Colour dyesFD&C blue #2 aluminum lakeSome people react to dyes such as tartrazine (Yellow 5) or carmine.
Titanium dioxidetitanium dioxideA whitening agent no longer allowed in food in the EU (E171).

Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.

Every version of this medicine (147)

The same active substance, strength and kind of form, from every company that sells it — with what each label lists.

Showing 80 of 80 (the first 80 are listed)

Same active substance, strength and form in other countries

Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.

Medicine passport: one printable page to show a pharmacist abroad

Canada7 matching products

Every strength and form (45)

NetherlandsNo exact match for this strength and form

Every strength and form (24)

Details

Made by	Allegiant Health
Active substance	Naproxen Sodium 220 Mg
Used in	Muscles, joints and bones
Strength	220 mg
Form	Tablet
Route	Oral
Packs	1 BOTTLE in 1 CARTON / 24 TABLET in 1 BOTTLE
NDC	69168-394

Source: NDC Directory · 2026-09-13 · not reviewed by a clinician

Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).

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Same active substance

These contain the same substance. That does not mean one can replace another — ask a pharmacist.

Naproxen Caplets All Day Relief for Pain220 mgWithout prescriptionTablet Allegiant Health · Naproxen Sodium 220 Mg

See every product with Naproxen Sodium 220 Mg