Naproxen Sodium
220 mg · Tablet, Film Coated
- Available without prescription
- Nonsteroidal Anti-inflammatory Drug
- Active substance
- Naproxen Sodium
- Used in
- Muscles, joints and bones
- Made by
- Padagis Israel Pharmaceuticals Ltd
- Source
- Official label
Quoted from the official source. Not yet reviewed by Mediclarum — the leaflet in your pack is authoritative.
At a glance
Quoted from the official label · 2026-02-11
Pain reliever/fever reducer
If you have ever had an allergic reaction to any other pain reliever/fever reducer
All warnings ↓- Sold without a prescription
- FDA enforcement reports list no ongoing recall, and none from the last two years, for this product code · checked 2026-10-02
Every line above is selected, not written, from the official label. Nothing is reworded. DailyMed
What it is for
temporarily relieves minor aches and pains due to:
- minor pain of arthritis
- muscular aches
- backache
- menstrual cramps
- headache
- toothache
- the common cold
- temporarily reduces fever
From the official label · 2026-02-11 · DailyMed
How it works
From the US prescribing label for the same active substance (Naproxen). It describes the substance, not this exact product.
Naproxen has analgesic, anti-inflammatory, and antipyretic properties.
The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
Naproxen is extensively metabolized in the liver to 6-0-desmethyl naproxen, and both parent and metabolites do not induce metabolizing enzymes.
Approximately 95% of the naproxen from any dose is excreted in the urine, primarily as naproxen (<1%), 6-0-desmethyl naproxen (<1%) or their conjugates (66% to 92%).
Quoted from the prescribing label, sections “Mechanism of Action” and “Pharmacokinetics”. DailyMed · 2026-08-18
Do not take it if
- if you have ever had an allergic reaction to any other pain reliever/fever reducer
- right before or after heart surgery
Quoted from the official label, section “OTC — Do Not Use”.
How to take it
These directions are for this exact strength and form. Another one is different.
- do not take more than directed
- the smallest effective dose should be used
- drink a full glass of water with each dose Adults and children 12 years and older
- take 1 tablet every 8 to 12 hours while symptoms last
- for the first dose you may take 2 tablets within the first hour
- do not exceed 2 tablets in any 8- to 12-hour period
- do not exceed 3 tablets in a 24-hour period Children under 12 years
- ask a doctor
Quoted from the official label, section “Dosage & Administration”.
Ask a doctor first if
- the stomach bleeding warning applies to you
- you have a history of stomach problems, such as heartburn
- you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke
- you are taking a diuretic
- you have problems or serious side effects from taking pain relievers or fever reducers
Quoted from the official label, section “OTC — Ask Doctor”.
Ask a pharmacist first if
- you are
- under a doctor’s care for any serious condition
- taking aspirin for heart attack or stroke, because naproxen may decrease this benefit of aspirin
- taking any other drug
Quoted from the official label, section “OTC — Ask Doctor/Pharmacist”.
Stop and get help if
- you experience any of the following signs of stomach bleeding:
- feel faint
- vomit blood
- have bloody or black stools
- have stomach pain that does not get better
- you have symptoms of heart problems or stroke:
- chest pain
- trouble breathing
- weakness in one part or side of body
- slurred speech
- leg swelling
- pain gets worse or lasts more than 10 days
- fever gets worse or lasts more than 3 days
- you have difficulty swallowing
- it feels like the pill is stuck in your throat
- redness or swelling is present in the painful area
- any new symptoms appear
Quoted from the official label, section “OTC — Stop Use”.
Other warnings
- Allergy alert:
- Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
- skin reddening
- rash
- blisters If an allergic reaction occurs,
- stop use and seek medical help right away. Stomach bleeding warning:
- This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher
- if you:
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take a blood thinning (anticoagulant) or steroid drug
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
- have 3 or more alcoholic drinks every day while using this product
- take more or for a longer time than directed Heart attack and stroke warning :
- NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher
- if you use more than directed or for longer than directed.
- Do not use
- right before or after heart surgery Ask a doctor before use if
- Ask a doctor or pharmacist before use
- if you are
- taking any other drug When using this product
- take with food or milk if stomach upset occurs Stop use and ask a doctor if
- feel faint
- vomit blood
- chest pain
- leg swelling
- any new symptoms appear If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use naproxen sodium at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
- Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).
- take with food or milk if stomach upset occurs
Quoted from the official label, section “Warnings”.
Pregnancy and breastfeeding
- If pregnant or breast-feeding, ask a health professional before use.
- It is especially important not to use naproxen sodium at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Quoted from the official label, section “OTC — Pregnancy or Breast Feeding”.
Keep away from children
In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).
Quoted from the official label, section “OTC — Keep Out of Reach of Children”.
How to store it
- each tablet contains: sodium 22 mg
- store at 20-25°C (68-77°F). Avoid high humidity and excessive heat above 40°C (104°F).
Quoted from the official label, section “Storage and Handling”.
What kind of medicine it is
Pain reliever/fever reducer
Quoted from the official label, section “OTC — Purpose”.
Other ingredients
Relevant if you react to a dye, a preservative, lactose or gluten.
FD&C blue no. 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, titanium dioxide
Quoted from the official label, section “Inactive Ingredients”.
Ingredients people check for
Lactose, gluten, dyes, sugars and other ingredients that matter with an allergy, intolerance or diet — as this product’s FDA label lists them.
- Colour dyes
FD&C blue no. 2 aluminum lake
Some people react to dyes such as tartrazine (Yellow 5) or carmine. - Titanium dioxide
titanium dioxide
A whitening agent no longer allowed in food in the EU (E171).
Quoted from the FDA label. A label that does not name an ingredient is not a guarantee that the product is free of it, and formulations change. With an allergy, check the pack and ask a pharmacist.
Every version of this medicine (147)
The same active substance, strength and kind of form, from every company that sells it — with what each label lists.
Showing 80 of 80 (the first 80 are listed)
- Naproxen SodiumThis oneWithout prescriptionPadagis Israel Pharmaceuticals LtdColour dyesTitanium dioxide
- Medique MediproxenWithout prescriptionA-S Medication SolutionsColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionA-S Medication SolutionsColour dyesTitanium dioxide
- Rugby All Day ReliefWithout prescriptionA-S Medication SolutionsColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionAAA Pharmaceutical, Inc.Colour dyesTitanium dioxide
- Bayer AleveWithout prescriptionAcme United CorporationColour dyesTitanium dioxide
- Naproxen CapletsWithout prescriptionAllegiant HealthColour dyesTitanium dioxide
- Naproxen Caplets All Day Relief for PainWithout prescriptionAllegiant HealthColour dyesTitanium dioxide
- Naproxen Sodium 220mgWithout prescriptionAllegiant HealthColour dyesTitanium dioxide
- Amazon Basic Care Naproxen SodiumWithout prescriptionAmazon.com Services LLCColour dyesTitanium dioxide
- Basic Care Naproxen SodiumWithout prescriptionAmazon.com Services LLCColour dyesTitanium dioxide
- Care One Naproxen SodiumWithout prescriptionAmerican Sales CompanyColour dyesTitanium dioxide
- Careone Naproxen SodiumWithout prescriptionAmerican Sales CompanyColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionAMERIFOODS TRADING COMPANYColour dyesTitanium dioxide
- NaproxenWithout prescriptionAmerisource BergenColour dyesTitanium dioxide
- Naproxen Sodium (nsaid) Fever Reducer/ Pain RelieverWithout prescriptionAmneal Pharmaceuticals of New York LLCColour dyesTitanium dioxide
- Exchange Select Naproxen SodiumWithout prescriptionArmy & Air Force Exchange ServiceColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionAthlete's Needs IncColour dyesTitanium dioxide
- Naproxen Sodium 220mgWithout prescriptionAthlete's Needs, Inc.Colour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionAurohealth LLCColour dyesTitanium dioxide
- Naproxen Sodium Back and Muscle PainWithout prescriptionAurohealth LLCColour dyesTitanium dioxide
- Naproxen Sodium Headache PainWithout prescriptionAurohealth LLCColour dyesTitanium dioxide
- Aleve Headache PainWithout prescriptionBayer HealthCare LLCColour dyesTitanium dioxide
- AleveWithout prescriptionBayer HealthCare LLC.Colour dyesTitanium dioxide
- Aleve Back and Muscle PainWithout prescriptionBayer HealthCare LLC.Colour dyesSugar alcoholsTitanium dioxide
- Aleve CapletsWithout prescriptionBayer HealthCare LLC.Colour dyesSugar alcoholsTitanium dioxide
- Aleve Caplets - Easy Open Arthritis CapWithout prescriptionBayer HealthCare LLC.Colour dyesTitanium dioxide
- Aleve Caplets Easy Open ArthritisWithout prescriptionBayer HealthCare LLC.Colour dyesSugar alcoholsTitanium dioxide
- Aleve Caplets Soft Grip ArthritisWithout prescriptionBayer HealthCare LLC.Colour dyesSugar alcoholsTitanium dioxide
- Aleve Easy Open ArthritisWithout prescriptionBayer HealthCare LLC.Colour dyesSugar alcoholsTitanium dioxide
- Aleve Easy Open Arthritis CapWithout prescriptionBayer HealthCare LLC.Colour dyesTitanium dioxide
- Aleve GelcapsWithout prescriptionBayer HealthCare LLC.Colour dyesGelatinTitanium dioxide
- Aleve Headache PainWithout prescriptionBayer HealthCare LLC.Colour dyesSugar alcoholsTitanium dioxide
- Ana-Dent Pain ReliefWithout prescriptionBelmora LLCTitanium dioxide
- AnadentWithout prescriptionBelmora LLCColour dyesTitanium dioxide
- Belmora FlanaxWithout prescriptionBelmora LLCColour dyesTitanium dioxide
- FlanaxWithout prescriptionBelmora LLCColour dyesTitanium dioxide
- Flanax Menstrual Pain RelieverWithout prescriptionBelmora LLCColour dyesTitanium dioxide
- Flanax Pain Reliever/Fever ReducerWithout prescriptionBelmora LLCTitanium dioxide
- Flanax Pain Reliever/Fever ReducerWithout prescriptionBelmora LLCTitanium dioxide
- Naproxen SodiumWithout prescriptionBETTER LIVING BRANDS LLC.Colour dyesTitanium dioxide
- NaproxenWithout prescriptionBetter Living Brands, LLCColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionBetter Living Brands, LLCColour dyesTitanium dioxide
- Pain ReliefWithout prescriptionBETTER LIVING BRANDS, LLCColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionBi-MartColour dyesTitanium dioxide
- Berkley and Jensen Naproxen SodiumWithout prescriptionBJWCColour dyesTitanium dioxide
- Good Sense Naproxen SodiumWithout prescriptionBryant Ranch PrepackColour dyesTitanium dioxide
- NaproxenWithout prescriptionBryant Ranch PrepackColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionBryant Ranch PrepackColour dyesTitanium dioxide
- Rugby All Day ReliefPrescription onlyBryant Ranch PrepackColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionCamber Consumer Care IncColour dyesTitanium dioxide
- Leader All Day Pain ReliefWithout prescriptionCardinal Health 110, LLC. dba LeaderColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionChain Drug Marketing AssociationColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionCHAIN DRUG MARKETING ASSOCIATION, INC.Colour dyesTitanium dioxide
- First Aid Direct All Day Pain ReliefWithout prescriptionCintas CorporationColour dyesTitanium dioxide
- Naproxen Sodium 220mgWithout prescriptionCommand Brands, LLCColour dyesTitanium dioxide
- Kirkland Signature Naproxen SodiumWithout prescriptionCostco Wholesale CompanyColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionCVSColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionCVS PharmacyColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionCVS Pharmacy, Inc.Colour dyesTitanium dioxide
- Back and Muscle PainWithout prescriptionCVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATEDColour dyesTitanium dioxide
- NaproxenWithout prescriptionDISCOUNT DRUG MARTColour dyesTitanium dioxide
- Dg Health Naproxen SodiumWithout prescriptionDolgencorp IncColour dyesTitanium dioxide
- Naproxen Sodium CapletsWithout prescriptionDr Reddy's Laboratories IncTitanium dioxide
- Naproxen Sodium Back and Muscle PainWithout prescriptionDr.Reddy's Laboratories IncTitanium dioxide
- Naproxen Sodium Back and Muscle Pain CapletsWithout prescriptionDr.Reddy's Laboratories IncTitanium dioxide
- Naproxen Sodium Headache PainWithout prescriptionDr.Reddy's Laboratories IncTitanium dioxide
- Naproxen Sodium Headache Pain CapletsWithout prescriptionDr.Reddy's Laboratories IncTitanium dioxide
- Naproxen SodiumWithout prescriptionDr.Reddy's Laboratories LimitedTitanium dioxide
- NaproxenWithout prescriptionFamily Dollar Services IncColour dyesTitanium dioxide
- Dr Simi All Day Pain ReliefWithout prescriptionFarmacias De Similares TX LLCColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionFSA STORE INC.Colour dyesTitanium dioxide
- NaproxenWithout prescriptionGeri-Care Pharmaceutical CorpColour dyesTitanium dioxide
- Pain ReliefWithout prescriptionGobrands, IncColour dyesTitanium dioxide
- Calmadol Pain RelieverWithout prescriptionGRANDALL DISTRIBUTING, LLCColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionGranules India LtdColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionGranules India LtdColour dyesTitanium dioxide
- Naproxen SodiumWithout prescriptionGranules USA, Inc.Colour dyesTitanium dioxide
- Naproxen Sodium 220mgWithout prescriptionGrocery OutletColour dyesTitanium dioxide
- All Day Pain ReliefWithout prescriptionH E BColour dyesTitanium dioxide
Same active substance, strength and form in other countries
Matched on active substance, strength and kind of form only. This is not a statement that the products are equivalent or interchangeable: other ingredients, release and approved uses can differ — ask a pharmacist before swapping.
Medicine passport: one printable page to show a pharmacist abroad
Canada7 matching products
- NAPROXEN SODIUM TABLETS 220 mg · tabletWithout prescription2 makers
- ALEVE CAPLETS 220 mg · tabletWithout prescription
- NAPROXEN 220 mg · tabletWithout prescription
- NAPROXEN MENSTRUAL PAIN RELIEF 220 mg · tabletWithout prescription
- NAPROXEN SODIUM CAPLETS 220 mg · tabletWithout prescription
- NAPROXEN SODIUM TABLETS USP 220 mg · tabletWithout prescription
NetherlandsNo exact match for this strength and form
Details
| Made by | Padagis Israel Pharmaceuticals Ltd |
|---|---|
| Active substance | Naproxen Sodium |
| Used in | Muscles, joints and bones |
| Strength | 220 mg |
| Form | Tablet, Film Coated |
| Route | Oral |
| Packs | 1 BOTTLE in 1 CARTON / 90 TABLET, FILM COATED in 1 BOTTLE |
| NDC | 45802-490 |
Source: NDC Directory · 2026-09-13 · not reviewed by a clinician
Source: US Food and Drug Administration, NDC Directory. Reuse terms: US government work (FDA).
Other strengths and forms
107 products are sold under this name. Grouped by form; a number on a strength means several companies make it.
- Capsule, Liquid Filled30 products
- Tablet, Film Coated29 products
275 mg3
275 mg · 3 companies
- Tablet24 products
275 mg3
- Tablet, Coated13 products
Show all forms · 6 forms
- Tablet, Film Coated, Extended Release10 products
- 220 mg
375 mg4
375 mg · 4 companies
500 mg3
500 mg · 3 companies
750 mg2
750 mg · 2 companies
- Capsule1 products
Same active substance
These contain the same substance. That does not mean one can replace another — ask a pharmacist.